Montelukast is as effective as penicillin in treatment of acute otitis media: An experimental rat study

Abstract

BackgroundLeukotrienes are the major factors in the formation of edema and mucus, as well as development of tuba Eustachii dysfunction in acute otitis media. We developed an experimental acute suppurative otitis media model and compared the responses of rats to penicillin and combinations of leukotriene antagonist with respect to histopathological observations conducted in early and late phases.Material/MethodsA total of 83 ears from 56 Wistar rats were used in this study. Pneumococcus suspension was injected trans-tympanically into all rats. Subjects were classified into 4 different groups with 14 rats in each. In Group A, intramuscular penicillin G was injected for a period of 5 days. In Group B, intraperitoneal montelukast was injected for 21 days in addition to penicillin. In Group C, intraperitoneal montelukast isotonic NaCl in Group D was injected into rats for 21 days.ResultsNo significant difference was found between the groups, except for mucosal vascularization with respect to mucosal and TM parameters in early phases. Furthermore, considerable deviations were observed for the recuperation of TM and mucosal inflammation for groups in which subjects were injected with montelukast as compared to other groups of the study in the late phases.ConclusionsWhen the parameters of inflammation in the rat middle ear were compared with each other, most of these parameters did not show any statistically significant beneficial effects in montelukast and penicillin groups.

Montelukast versus inhaled mometasone for treatment of otitis media with effusion in children: A randomized controlled trial

“…Their sample size were higher in comparison to our study. Some studies such as the study by Ucar et al confirms our findings that montelukast is not effective in treatment of OME ( 11 ). The study by Ucar et al is done on rats.…”

“…Montelukast is a leukotriene antagonist, which is used in children ( 11 ). In OME, several medications are recommended, including antibiotics, antihistamines, and inhaled and oral corticosteroids, but the treatment response is controversial ( 9 , 10 , 14 , 15 ).…”

“…The efficacy of these medications in treatment of OME is limited, and the surgical treatment of tube insertion in tympan is associated with stress and needs anesthesia ( 16 ). The results of studies about the efficacy of monteleukast in management of OME are controversial ( 11 , 17 – 20 ). Some researchers have reported its efficacy in treatment of OME.…”

Effect of Montelukast, a Cysteinyl Leukotriene Receptor-1 Antagonist, on a Rat Model of Acute Bacterial Sinonasal Inflammation

“…An otitis media study showed that it is as effective as penicillin. 47 In the same study, it has been shown that MONT inhibits inflammatory cell activation, which reduces vascular permeability and activates mucociliary clearance. Studies have shown that MONT administration in rat models inhibits oxidative damage and decreases the amount of cytokine.…”

Deneysel hayvan çalışmalarında montelukast

“…Uçar ve ark. nın akut otitis tedavisinde en az penisilin kadar etkili olduğu gösterilmiştir [16]. Deneysel kanser ça-lışmalarında Savari ve ark.…”