Monthly Update: Biologicals &amp; Immunologicals: The autoimmunity of cancer as applied to drug development

McKnight, Michael E.; Glassy, Mark C.

doi:10.1517/13543784.4.7.657

Cited by 4 publications

(6 citation statements)

References 20 publications

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“…Both practical and theoretical uses and limitations of using lymphocytes isolated from regional draining, lymph nodes of cancer patients have been discussed (Glassy andMcKnight. 1994: McKnight andGlassy. 1995).…”

mentioning

confidence: 99%

A human natural antibody to adenocarcinoma that inhibits tumour cell migration

Koda

Nakajima²,

Saito³

et al. 1998

Br J Cancer

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mentioning

confidence: 99%

A human natural antibody to adenocarcinoma that inhibits tumour cell migration

Koda

Nakajima²,

Saito³

et al. 1998

Br J Cancer

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“…The seemingly limitless specificity of the antibody molecule is ripe for a drug discovery programme [9][10][11][12]. A simple decision analysis diagram of this discovery program is shown in Figure 1.…”

Section: Drug Discoverymentioning

confidence: 99%

“…These identified novel tumour antigens can also serve as prospective drugs [9,12]. These antigens can be exploited as new biomolecules for drug development.…”

Section: Glassy Yasutomi and Koda 997mentioning

confidence: 99%

“…Due to the high specificity of human antibodies, they can also serve as an important method for novel drug discovery [9][10][11][12]. This is based on the premise that the natural human immune response to self-tumour antigens is significant for the discovery of clinically useful anticancer antigens.…”

Section: Introductionmentioning

confidence: 99%

“…This is based on the premise that the natural human immune response to self-tumour antigens is significant for the discovery of clinically useful anticancer antigens. In this respect, an autoimmune-like response to self-tumour antigens has developed [12] and it is this set of antigens, many of which will be novel, which will serve as the next generation of therapeutics. As stated, these antibodies can be used to identify interesting tumour antigens.…”

Section: Introductionmentioning

confidence: 99%

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Lessons learned about the therapeutic potential of the natural human immune response to lung cancer

Glassy¹,

Yasutomi²,

Koda³

1999

Expert Opinion on Investigational Drugs

Self Cite

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Lung cancer is the leading cause of cancer deaths; patients with this disease often develop antibodies to their own tumour antigens. TB94 is one such human antibody, and was obtained from the natural immune response from a patient with lung cancer. The data generated so far on TB94 suggest that this human antibody may have clinical applications in the diagnosis and treatment of lung cancer. Since humans make antibodies to tumour antigens, the intelligence of the human immune response can be exploited for the discovery of potential novel antigens. These novel antigens can then be developed for vaccine applications. Creating effective strategies to analyse systematically the natural human immune response to tumour antigens will open up new areas of immunotherapy for the control and eradication of disease.

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Isotype-Directed Enrichment of B Cells by Magnetic Beads in the Generation of Immunoreactive Human Monoclonal Antibodies

McKnight¹,

Mukerjee²,

Nasoff³

et al. 1996

Hybridoma

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Pooled lymphocytes collected from cancer patients were mixed with a biotinylated murine MAb specific to human IgG4. To this were added streptavidin-conjugated magnetic beads. After magnetically separating the bead-lymphocyte complex, the B cells were washed and fused with the WIL-2 derived human fusion partner, SHFP-1. Subsequently derived human-human hybridomas were screened for IgG4 immunoreactivity to target tumor cell lines. Several hybridomas reacted with a variety of malignant cell types, including melanoma, neuroblastoma, and pancreatic tumor cells. One hybridoma in particular, designated SC-GM4, recognized an antigen by Western blot with an apparent molecular weight of 57 kDa. This facile approach of magnetically separating selected populations of lymphocytes should be relatively simple to apply to other antigens and antibodies to preselect the type, class, and properties of the desired MAb.

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Monthly Update: Biologicals & Immunologicals: The autoimmunity of cancer as applied to drug development

Cited by 4 publications

References 20 publications

A human natural antibody to adenocarcinoma that inhibits tumour cell migration

A human natural antibody to adenocarcinoma that inhibits tumour cell migration

Lessons learned about the therapeutic potential of the natural human immune response to lung cancer

Isotype-Directed Enrichment of B Cells by Magnetic Beads in the Generation of Immunoreactive Human Monoclonal Antibodies

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