Monthly variation in the plasma copper and zinc concentration of pregnant and non‐pregnant mares

Auer, D. E.; Ng, J. C.; Steele, D. P.; Wright, A.

doi:10.1111/j.1751-0813.1988.tb07354.x

Cited by 7 publications

(1 citation statement)

References 6 publications

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“…Dietary copper intake is thought to account for some of the variability in plasma and serum copper concentration in horses (Stubley et al 1983;Auer et al 1988a;Mee and McLaughlin 1995), but this was not evident in this study. In another study, horses fed diets containing either 7 or 30 mg Cu/kg DM did not exhibit detectable differences in serum copper concentration despite large increases in liver copper and fewer bone and cartilage lesions in the high copper intake group (Hurtig et al 1990).…”

Section: Discussionmentioning

confidence: 59%

Effect of copper supplementation on the copper status of pasture‐fed young Thoroughbreds

Pearce

Grace

Firth

et al. 1998

Equine Veterinary Journal

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Summary The effect of copper supplementation of pasture fed mares and foals on the copper status of the foals, in terms of plasma, soft tissue and bone copper concentrations and caeruloplasmin activity, was investigated. Twenty‐one Thoroughbred foals from either control mares (n = 9), or copper‐supplemented mares (n = 12) were divided randomly into control (pasture only, n = 10) or supplemented (pasture and oral copper sulphate, n = 11) groups. The pasture diet was grazed by all animals, and contained 4.4–8.6 mg Cu/kg dry matter (DM). The copper supplement for the mares contained copper sulphate equivalent to 0.5 mg Cu/kg liveweight (LW)/day. This daily dose was converted to allow administration as a thrice weekly dose (i.e. multiplied by 7/3) which was given for 13–25 weeks prior to foaling. The supplemented foals, also dosed 3 times a week, received 0.2 mg Cu/kg LW/day at age 21 days, which was increased to 0.5 mg Cu/kg LW/day at 49 days and was continued at this level until euthanasia at 150 days. Foal plasma copper concentration and caeruloplasmin activity increased from birth to 21 days post partum and then plateaued at a concentration similar to the mare, but the rise in these indices was not affected by copper supplementation of the mare or foal. Copper supplementation of the foal increased foal liver copper concentration at 150 days (P<0.03). Copper intake of diets containing approximately 8–28 mg Cu/kg DM is well reflected by liver copper concentration, but is poorly reflected by bone, other soft tissue copper concentrations and circulating copper status indices.

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Section: Discussionmentioning

confidence: 59%

Effect of copper supplementation on the copper status of pasture‐fed young Thoroughbreds

Pearce

Grace

Firth

et al. 1998

Equine Veterinary Journal

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The effect of high pasture molybdenum concentrations on the copper status of grazing horses in New Zealand

Pearce

Firth

Grace

et al. 1999

New Zealand Journal of Agricultural Research

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The objective of this study was to determine whether Mo causes secondary Cu deficiency in pasture-fed horses. Twelve Thoroughbred weanling fillies were divided into two groups and fed either high Mo pasture (8 to 15 mg Mo kg" 1 DM) or a low Mo pasture (0.6 to 1.2 Mo kg 1 DM) for 84 days. Both pastures contained 6 to 9 mg Cu kg" 1 DM. The animals were challenged with Cu over the last 14 days to determine change in their Cu status to 1.0 mg Cu kg" 1 liveweight d" 1 given orally three times a week. Copper status was assessed from liver, plasma, blood cell, and plasma trichloroacetic acid-insoluble Cu concentrations as well as the enzyme activities of plasma caeruloplasmin and red blood cell superoxide dismutase. None of these indices was affected by the increase in Mo intake. Horses grazing pasture high in Mo responded no differently to Cu challenge than did those on low Mo pasture. The results of this study suggest that Mo is unlikely to increase dietary Cu requirements and induce secondary Cu deficiency at the Cu and Mo concentrations normally found in New Zealand pastures grazed by Thoroughbreds.

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Copper salicylate and copper phenylbutazone as topically applied anti‐inflammatory agents in the rat and horse

Auer

Seawright

1990

Vet Pharm & Therapeutics

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Topically applied copper phenylbutazone, phenylbutazone, copper salicylate, salicylate and dimethylsulfoxide glycerol (80:20) were investigated as anti-inflammatory agents in rats and horses. Dimethylsulfoxide and glycerol (80:20) or dimethylsulfoxide, ethanol and glycerol (60:20:20) were used as the drug solvents. Subcutaneously administered carrageenin was used to induce inflammatory oedema, either in the paws of rats or the alar fold of the horse. The severity of the oedema and the anti-inflammatory effect of the drugs were assessed by measuring changes in the paw or alar-fold diameters. Copper salicylate and copper phenylbutazone were effective inhibitors of the inflammatory oedema in both species, but dimethylsulfoxide:glycerol (80:20) was not. In the rat, copper salicylate and copper phenylbutazone were superior anti-inflammatory agents compared to either salicylate or phenylbutazone, respectively. Following the topical application of four times the recommended daily dose of copper phenylbutazone to the horse for 5 days, minor skin irritation occurred and trace concentrations of phenylbutazone (maximum 0.6 microgram/ml) and negligible concentrations of oxyphenbutazone and gamma-hydroxyphenylbutazone were detected in the plasma.

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Monthly variation in the plasma copper and zinc concentration of pregnant and non‐pregnant mares

Cited by 7 publications

References 6 publications

Effect of copper supplementation on the copper status of pasture‐fed young Thoroughbreds

Effect of copper supplementation on the copper status of pasture‐fed young Thoroughbreds

The effect of high pasture molybdenum concentrations on the copper status of grazing horses in New Zealand

Copper salicylate and copper phenylbutazone as topically applied anti‐inflammatory agents in the rat and horse

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