Monthly variation in univentricular heart and transposition of the great arteries – 10–year national population-based cohort study

Abstract

Objective: Monthly variation in the total prevalence of the univentricular heart (UVH) and dextrotransposition of the great arteries (d-TGA) at gestational age 7 + 0 weeks was assessed to determine potential environmental factors, such as viral or bacterial infections, underlying the variation. Study design: The nationwide retrospective ten-year population-based cohort consisted of 592 733 births and 2764 terminated pregnancies due to fetal anomaly. The pre-or postnatally diagnosed cases of UVH (n = 440) and simple d-TGA (n = 127) from five national registers included live births, stillbirths, and pregnancy terminations due to fetal anomaly. We evaluated the variation in the monthly total prevalence of UVH and d-TGA at gestational age 7 + 0 weeks. The monthly variation of UVH and d-TGA was also compared with monthly variation in reported viral and bacterial infections. Results: In the UVH and d-TGA, we observed significant monthly variation in total prevalence. However, we observed no correlations in the studied viral or bacterial infections and the number of cases. Conclusions: Assessing monthly variation in total prevalence at early pregnancy, including pregnancy terminations and stillbirths, and using first-trimester timing provides the most accurate information on the variation. The reasons for monthly variation remain unclear, but we observed no associations with specific viral or bacterial infections.

Effect of health education based on information-motivation-behavioral skills model on patients with unilateral vestibular dysfunction

“…Some scholars used the medical-nursing cooperation model to care for patients with VH, and the results showed that this model can effectively promote the functional recovery of patients[ 12 ]. The effect of health guidance based on the WeChat platform on the rehabilitation management of patients with vestibular function was investigated[ 13 ]. The rehabilitation management based on the WeChat platform enhanced the supervision of patients' rehabilitation training and promoted the improvement of patients' vertigo symptoms[ 14 ].…”

Maternal first trimester metabolic profile in pregnancies with transposition of the great arteries

“…Congenital heart defects (CHD) are the most common congenital anomalies, and transposition of the great arteries (TGA) is one of the most frequent cyanotic CHD in neonates. The birth prevalence of TGA is approximately 2–3 per 10,000 (Hautala et al, 2021; Liu et al, 2019). More than 50% of infants will die by the first month of life and 89.3% in the first year if TGA is left untreated (Liebman et al, 1969), but when treated, this condition has a good prognosis: in a single‐center South Korean study the survival rate of operated patients was 96% at 20 years (Choi et al, 2010).…”

Maternal first trimester metabolic profile in TGA pregnancies - a case-control study

“…Congenital heart defects (CHD) are the most common congenital anomalies, and transposition of the great arteries (TGA) is one of the most frequent cyanotic CHD in neonates. The birth prevalence of TGA is approximately 2-3 per 10,000 (1,2). Maternal diabetes (3,4), higher haemoglobin A1C (5), and elevated random plasma glucose values in the first trimester in mothers without diabetes (6) have been associated with an increased risk for CHD in the offspring.…”