Montmorency tart cherry protects against age-related bone loss in female C57BL/6 mice and demonstrates some anabolic effects

Bj, Smith; Crockett, Erica K.; Chongwatpol, Pitipa; Graef, Jennifer L; Clarke, Stephen; Rendina-Ruedy, Elizabeth; Lucas, Edralin A.

doi:10.1007/s00394-018-1848-1

Cited by 10 publications

(8 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since diverse study designs have been carried out, in human or animal models, and at many dosages of tart cherry, the results are quite variable. Beneficial effects of tart cherry supplementations were found in female rats, protecting early age-related bone loss and increasing bone mineralization [73]; therefore, it would be interesting to extend the study to female rats. Aside from our current results in male rats, there is wide evidence that demonstrates that tart cherry ingestion provides anti-inflammatory and anti-oxidative activities both in vivo and in vitro [63,67,[74][75][76][77][78][79].…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Antioxidant Properties of Tart Cherry Consumption in the Heart of Obese Rats

Martinelli

Tomassoni

Bellitto

et al. 2022

Biology

View full text Add to dashboard Cite

Obesity is a risk factor for cardiovascular diseases, frequently related to oxidative stress and inflammation. Dietary antioxidant compounds improve heart health. Here, we estimate the oxidative grade and inflammation in the heart of dietary-induced obese (DIO) rats after exposure to a high-fat diet compared to a standard diet. The effects of tart cherry seed powder and seed powder plus tart cherries juice were explored. Morphological analysis and protein expressions were performed in the heart. The oxidative status was assessed by the measurement of protein oxidation and 4-hydroxynonenal in samples. Immunochemical and Western blot assays were performed to elucidate the involved inflammatory markers as proinflammatory cytokines and cellular adhesion molecules. In the obese rats, cardiomyocyte hypertrophy was accompanied by an increase in oxidative state proteins and lipid peroxidation. However, the intake of tart cherries significantly changed these parameters. An anti-inflammatory effect was raised from tart cherry consumption, as shown by the downregulation of analyzed endothelial cell adhesion molecules and cytokines compared to controls. Tart cherry intake should be recommended as a dietary supplement to prevent or counteract heart injury in obese conditions.

show abstract

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Antioxidant Properties of Tart Cherry Consumption in the Heart of Obese Rats

Martinelli

Tomassoni

Bellitto

et al. 2022

Biology

View full text Add to dashboard Cite

show abstract

“…To our knowledge, there are no studies that have documented lifespan effects of TCE in mammalian and only one study has showed TCE effects in model organisms [54]. Some studies have shown that TC improves memory, autophagy, and hippocampal inflammation in aged rats [52] and protects against age-related bone loss in mice [55]. Studies in C. elegans with blueberries (50, 100, and 200 mg/ml of extract) demonstrated increased MLS by 22.2%, 36.5%, and 44.4% [27] and 5 mg/ml of blueberry extracts extended MLS of Drosophila by 10% [17].…”

Section: Tce Increases Lifespan Through Iis and Daf-16 Pathwaymentioning

confidence: 99%

Tart Cherry Increases Lifespan in Caenorhabditis elegans by Altering Metabolic Signaling Pathways

et al. 2020

View full text Add to dashboard Cite

Aging and healthspan are determined by both environmental and genetic factors. The insulin/insulin-like growth factor-1(IGF-1) pathway is a key mediator of aging in Caenorhabditis elegans and mammals. Specifically, DAF-2 signaling, an ortholog of human IGF, controls DAF-16/FOXO transcription factor, a master regulator of metabolism and longevity. Moreover, mitochondrial dysfunction and oxidative stress are both linked to aging. We propose that daily supplementation of tart cherry extract (TCE), rich in anthocyanins with antioxidant properties may exert dual benefits for mitochondrial function and oxidative stress, resulting in beneficial effects on aging in C. elegans. We found that TCE supplementation at 6 μg or 12 μg/mL, increased (p < 0.05) the mean lifespan of wild type N2 worms, respectively, when compared to untreated control worms. Consistent with these findings, TCE upregulated (p < 0.05) expression of longevity-related genes such as daf-16 and aak-2 (but not daf-2 or akt-1 genes) and genes related to oxidative stress such as sod-2. Further, we showed that TCE supplementation increased spare respiration in N2 worms. However, TCE did not change the mean lifespan of daf-16 and aak-2 mutant worms. In conclusion, our findings indicate that TCE confers healthspan benefits in C. elegans through enhanced mitochondrial function and reduced oxidative stress, mainly via the DAF-16 pathway.

show abstract

“… 38-42 Dietary supplementation with TC prevented bone loss in a rheumatoid arthritis model and restored age-related loss of trabecular and cortical bone. 41 , 42 Postmenopausal women consuming TC juice twice daily exhibited a decrease in the bone resorption marker, tartrate-resistant acid phosphatase type 5b. 43 Phenolic acids reduce osteoclastogenesis by inhibiting the receptor activator of nuclear factor κB (RANKL) and promoting osteoblast differentiation via TGF-β signaling in both bone and gut in a Treg cell differentiation–dependent manner.…”

Section: Introductionmentioning

confidence: 99%

Fructooligosaccharides act on the gut–bone axis to improve bone independent of Tregs and alter osteocytes in young adult C57BL/6 female mice

Islam,

Ice,

Alake

et al. 2024

JBMR Plus

View full text Add to dashboard Cite

Targeting the gut-bone axis with probiotics and prebiotics is considered a promising strategy to reduce the risk of osteoporosis. Gut-derived short chain fatty acids (SCFA) mediate the effects of probiotics on bone via T regulatory cells (Tregs), but it is not known whether prebiotics act through a similar mechanism. We investigated how two different prebiotics, tart cherry (TC) and fructooligosaccharide (FOS), affect bone, and whether Tregs are required for this response. Eight-week-old C57BL/6 female mice were fed diets supplemented with 10% w/w TC, FOS or a control (Con; AIN-93 M) diet and received an isotype control or CD25 antibody to suppress Tregs. FOS diet increased bone mineral content, density, and trabecular bone volume in the vertebra (~40%) and proximal tibia (~30%) compared to the TC and control diets, irrespective of CD25 treatment. Both prebiotics increased (P < 0.01) fecal SCFAs, but the response was greater with FOS. To determine how FOS affected bone cells, we examined genes involved in osteoblast and osteoclast differentiation and activity as well as genes expressed by osteocytes. FOS increased the expression of regulators of osteoblast differentiation (bone morphogenetic protein 2 [Bmp2], Wnt family member 10b [Wnt10b] and Osterix [Osx]) and type 1 collagen [Col1α1]). Osteoclasts regulators were unaltered. FOS also increased the expression of genes associated with osteocytes, including phosphate regulating endopeptidase x-linked (Phex), matrix extracellular phosphoglycoprotein (Mepe), and dentin matrix acidic phosphoprotein 1 (Dmp-1). However, Sost, the gene that encodes for sclerostin was also increased by FOS as was the number and density of osteocytes. These findings demonstrate that FOS has a greater effect on bone mass and structure in young adult female mice than TC and its influence on osteoblasts and osteocytes is not dependent on Tregs.

show abstract

Montmorency tart cherry protects against age-related bone loss in female C57BL/6 mice and demonstrates some anabolic effects

Cited by 10 publications

References 43 publications

Anti-Inflammatory and Antioxidant Properties of Tart Cherry Consumption in the Heart of Obese Rats

Anti-Inflammatory and Antioxidant Properties of Tart Cherry Consumption in the Heart of Obese Rats

Tart Cherry Increases Lifespan in Caenorhabditis elegans by Altering Metabolic Signaling Pathways

Fructooligosaccharides act on the gut–bone axis to improve bone independent of Tregs and alter osteocytes in young adult C57BL/6 female mice

Contact Info

Product

Resources

About