Montmorillonite-alginate composites as a drug delivery system: Intercalation and In vitro release of diclofenac sodium

Kevadiya, BD; Joshi, GV; Abdi, Sayed H. R.; Bajaj, HC

doi:10.4103/0250-474x.84582

Cited by 37 publications

(7 citation statements)

References 15 publications

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“…Therefore, in the fingerprint region, the band at 1645 cm −1 corresponding to the group stretching vibrations of the newly formed imine bonds between chitosan and citral appeared in the spectra of the drug delivery systems, while the vibration of the aldehyde unit of cytral (1675 cm −1 ) disappeared, indicating that the imination process was not impeded by the presence of DCF ( Figure 1 ). Upon a deeper view, it could be observed that the band at 1725 cm −1 , which is characteristic of the stretching vibrations of the C=O groups in the IR spectrum of the DCF drug, also appeared in the spectra of the drug delivery systems as a shoulder, which was a sign of DCF’s presence in the matrix [ 26 , 27 ]. Moreover, this band was a little bit shifted in the spectra of the drug delivery systems, very probably due to the strong interactions with the matrix.…”

Section: Resultsmentioning

confidence: 99%

Hydrogels Based on Imino-Chitosan Amphiphiles as a Matrix for Drug Delivery Systems

Ailincai¹,

Porzio

Marin³

2020

Polymers

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This paper reports new formulations based on chitosan, citral, and diclofenac sodium salt (DCF). The central idea was to encapsulate an anionic drug into a polycationic hydrogel matrix in order to increase the intermolecular forces between them and thus to ensure slower drug release, while citral was used as a penetration enhancer to assure efficient delivery of the drug. Hydrogels without drug were also synthesized and used as a reference. The structure, morphology, and supramolecular architecture of the drug delivery systems were evaluated by FTIR spectroscopy, scanning electron microscopy, polarized optical microscopy, and wide-angle X-ray diffraction. The drug release kinetics was monitored in vitro by UV-VIS spectroscopy, in physiological conditions, while the enzymatic and hydrolytic degradability of the hydrogels were evaluated in the presence of lysozyme and phosphate buffer saline (PBS), at 37 °C. All of the data revealed that the anionic DCF was strongly anchored into the polycationic matrix and the drug was slowly released over 7 days. Moreover, the release rate can be controlled by simple variation of the molar ratio between the polycationic chitosan and lipophilic citral.

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Section: Resultsmentioning

confidence: 99%

Hydrogels Based on Imino-Chitosan Amphiphiles as a Matrix for Drug Delivery Systems

Ailincai¹,

Porzio

Marin³

2020

Polymers

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“…The vibrational band at about 1734 cm −1 corresponds to C=O stretching of PVA and SA [21] [22]. The band at about 836 cm −1 is attributed to AlMgOH bending vibrations [23]. In the case of MMT filled PVA/SA, FR-IR spectra shows shifts in some bands (1423 cm −1 , 1243 cm −1 and 1086 cm −1 ) which is essentially due to Si-O stretching: out of plane and in-plane which is absent in pure films.…”

Section: Ft-ir Studiesmentioning

confidence: 97%

Preparation and Characterization of MMT Doped PVA/SA Polymer Composites

Hemalatha¹,

Somashekarappa

Somashekar³

2014

AMPC

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Blends of PVA/SA polymer doped with Montmorillonite were prepared by solution casting technique. Doping of nanoparticles to the polymer matrix does affect the structural and conducting properties. To analyze such changes, these films were subjected to X-ray diffraction, FT-IR spectroscopy, UV-visible absorbance and impedance analysis. Microstructural parameters were computed using in-house program employing X-ray data. Electrical conductivity of these polymer composites was derived using obtained impedance values to understand the conducting property. The results thus obtained are reported in this work.

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“…Montmorillonite layers and sheets in bentonite make it a suitable nanoclay for drug delivery [28,29]. Its use in sustained and targeted drug release for targeted chemotherapy has also been investigated [30][31][32].…”

Section: Bentonitementioning

confidence: 99%

Therapeutic Applications of Halloysite

Mobaraki

Karnik

et al. 2021

Applied Sciences

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In recent years, nanomaterials have attracted significant research interest for applications in biomedicine. Many kinds of engineered nanomaterials, such as lipid nanoparticles, polymeric nanoparticles, porous nanomaterials, silica, and clay nanoparticles, have been investigated for use in drug delivery systems, regenerative medicine, and scaffolds for tissue engineering. Some of the most attractive nanoparticles for biomedical applications are nanoclays. According to their mineralogical composition, approximately 30 different nanoclays exist, and the more commonly used clays are bentonite, halloysite, kaolinite, laponite, and montmorillonite. For millennia, clay minerals have been extensively investigated for use in antidiarrhea solutions, anti-inflammatory agents, blood purification, reducing infections, and healing of stomach ulcers. This widespread use is due to their high porosity, surface properties, large surface area, excellent biocompatibility, the potential for sustained drug release, thermal and chemical stability. We begin this review by discussing the major nanoclay types and their application in biomedicine, focusing on current research areas for halloysite in biomedicine. Finally, recent trends and future directions in HNT research for biomedical application are explored.

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Montmorillonite-alginate composites as a drug delivery system: Intercalation and In vitro release of diclofenac sodium

Cited by 37 publications

References 15 publications

Hydrogels Based on Imino-Chitosan Amphiphiles as a Matrix for Drug Delivery Systems

Hydrogels Based on Imino-Chitosan Amphiphiles as a Matrix for Drug Delivery Systems

Preparation and Characterization of MMT Doped PVA/SA Polymer Composites

Therapeutic Applications of Halloysite

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