Montmorillonite as an agent for drug photostability

Clay-biosurfactant materials as functional drug delivery systems: Slowing down effect in the in vitro release of cinnamic acid

“…Considerable efforts have therefore been devoted to the design of appropriate drug delivery systems (DDS) aimed at improving the efficiency and the safety of the product (Kulkarni et al, 2011). In this context clay minerals have been investigated as fundamental constituents of several DDS (Aguzzi et al, 2007;Ambrogi et al, 2012;Calabrese et al, 2013a ;Carretero, 2002;Choy et al, 2007;Iliescu et al, 2011;Nunes et al, 2007;Rodrigues et al, 2013;Viseras et al, 2010;Zheng et al, 2007).…”

“…Specifically, montmorillonite (Mt), whose structure consists of two silica tetrahedral sheets sandwiching an edge-shared octahedral sheet of aluminum (T-O-T sheets), attracted a great deal of attention in the research of drug administration (Ambrogi et al, 2012;Carretero, 2002;Cavallaro et al, 2015;Gereli et al, 2006;Lal and Datta, 2012;Lin et al, 2002;Massaro et al, 2015;Wang et al, 2008) because of its noteworthy properties including large specific surface area, good adsorption ability, cations exchange capacity, adhesive ability, and drug-carrying and releasing capability.…”

Trapping characteristic of halloysite lumen for methyl orange

“…Under the same irradiation time, the dye-loaded HNTs shows a smaller value of the color difference compared with the physical mixture, indicating a better photostability [38]. We know that particulate methyl orange existed in the physical mixture should has a higher photostability in comparison with single MO molecule or a few MO molecules aggregation [40]. However, the results show that several dye molecular aggregates by adsorption on the HNTs present a better photostability.…”

Modified montmorillonite nanolayers for nano-encapsulation of biomolecules

“…Montmorillonite is known as a new smart carrier introducing new mechanisms of adsorption enabling highly controlled delivery procedures such as pH-responsive in addition to drug protection from chemical denaturation [ 21 , 22 , 23 ]. All these functional characteristics are due to the cation exchange property which enables the montmorillonite for adsorption of the different biomolecules [ 23 , 24 ].…”

“…All these functional characteristics are due to the cation exchange property which enables the montmorillonite for adsorption of the different biomolecules [ 23 , 24 ]. Adsorption characteristics of different biomolecules onto montmorillonite has been studied for food and nutrition applications or drug delivery applications [ 12 , 21 ] such as promethazine hydrochloride [25] , tetracycline [26] , timolol maleate [27] , vitamin B6 [11] , and vitamin B12 [ 12 , 23 ]. In all these studies biomolecules are adsorbed onto different sites of the montmorillonite such as in the interlayer spaces, the external surfaces, and the edges of montmorillonite [28] .…”