Montmorillonite clay nanocomposites for drug delivery

Haque, Sufia ul; Nasar, Abu; Inamuddin, .

doi:10.1016/b978-0-12-813741-3.00028-5

Cited by 15 publications

(13 citation statements)

References 90 publications

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“…Figure 3 shows that before adsorption, the wave numbers of 1313 cm −1 and 1596 cm −1 are the stretching vibration of C-OH and C=C, and the strong absorption band at 1021 cm −1 is the skeleton vibration band of Si--O--Si [29]. A broad band appears in the wave number range of 3300-3500 cm −1 , which is attributed to the stretching vibration of N--H bond or O--H bond [30,31]. After the adsorption of Cu 2+ , the intensity of the characteristic peak changed to some extent, from 1430 cm −1 and 1636 cm −1 to 1421 cm −1 and 1618 cm −1 , and the intensity of the characteristic peak at 1368 cm −1 also decreased significantly.…”

Section: Ftir Analysismentioning

confidence: 99%

Study on the Performance of Composite Adsorption of Cu2+ by Chitosan/β-Cyclodextrin Cross-Linked Zeolite

Xiong

Zhang

2022

Sustainability

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In order to remove Cu2+ from wastewater, a kind of microsphere adsorbent (SCDO) with high efficiency for Cu2+ adsorption was prepared by the microdrop condensation method, where chitosan (CTS) and sodium alginate (SA) were used as the matrix to crosslink β-cyclodextrin (β-CD) and zeolite (Zeo). The structure and properties of SCDO were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS). Upon that, the adsorption performance of SCDO for Cu2+ was studied, in which the effects of pH, initial concentration, dosage, adsorption time and temperature were investigated. The results showed that the removal rate of Cu2+ reached 97.08%, and the maximum adsorption capacity was 24.32 mg/g with the temperature at 30 °C, the dosage of SCDO at 12 g/L, the initial concentration of Cu2+ at 100 mg/L, the pH of the solution at 6.0 and the adsorption time at 120 min, respectively. The adsorption process of Cu2+ by SCDO occurred in accordance with quasi-second-order kinetics model and Langmuir adsorption isotherm. After four repeats of continuous adsorption and desorption, the regenerative removal rate of Cu2+ could still reach 84.28%, which indicated that SCDO had outstanding reusability.

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Section: Ftir Analysismentioning

confidence: 99%

Study on the Performance of Composite Adsorption of Cu2+ by Chitosan/β-Cyclodextrin Cross-Linked Zeolite

Xiong

Zhang

2022

Sustainability

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“…The cyclic voltammetry curves depicted in Figure 2 displayed the glassy carbon modified electrode with Pth@NiO/Frt/GOx showing a significant electrocatalytic redox activity. This might be due to the Frt resulting in a better dispersion of the composite, causing an enhancement in the bioelectrocatalytic reaction of the modified glassy carbon electrode [38]. The cyclic voltammetry studies of Pth@NiO/Frt/GOx GC modified electrode at a scan rate of 100 mV/s in PBS of pH 7.0 provides a current of 3.2 mA/cm 2 , whereas repeating the same experiment in presence of 40 mM glucose that was pre-optimized, the current has increased to 5.4 mA/cm 2 .…”

Section: Electrochemical Analysesmentioning

confidence: 99%

“…This clearly indicates that the combination of Frt and GOx provided the required redox reaction, causing electron transfer towards the Pth@NiO modified glassy carbon electrode. The outstanding electrical connection came into existence due to the synergistic effects of the composite that allows for the easier shuttling of electrons from deeply buried redox active sites of GOx to the surface of electrode [3,39]. The redox property of the composite emerged due to the incorporation of NiO significantly enhances the catalytic activity towards glucose oxidation reaction.…”

Section: Electrochemical Analysesmentioning

confidence: 99%

“…The increase in current density was observed with the successive addition of glucose concentration up to 40 mM, beyond that the redox current acquired saturation because the bioelectrocatalytic redox reaction was slowed down by the higher glucose concentration. This saturated current might be due to the saturation kinetics of the redox reaction, which is offering steady-state equilibrium in the redox current and remains stable, even after the further increment in the glucose concentration [3,39,44]. Figure 5B shows a typical calibration curve for the oxidation peak current vs. the glucose concentration.…”

Section: Electrochemical Analysesmentioning

confidence: 99%

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Application of Electrically Conducting Nanocomposite Material Polythiophene@NiO/Frt/GOx as Anode for Enzymatic Biofuel Cells

Inamuddin

Alamry

2020

Materials

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In this work, nano-inspired nickel oxide nanoparticles (NiO) and polythiophene (Pth) modified bioanode was prepared for biofuel cell applications. The chemically prepared nickel oxide nanoparticles and its composite with polythiophene were characterized for elemental composition and microscopic characterization while using scanning electron microscopy. The electrochemical characterizations of polythiophene@NiO composite, biocompatible mediator ferritin (Frt) and glucose oxidase (GOx) catalyst modified glassy carbon (GC) electrode were carried out using cyclic voltammetry (CV), linear sweep voltammetry (LSV), and charge-discharge studies. The current density of Pth@NiO/Frt/GOx bioanode was found to be 5.4 mA/cm2. The bioanode exhibited a good bio-electrocatalytic activity towards the oxidation of the glucose. The experimental studies of the bioanode are justifying its employment in biofuel cells. This will cater a platform for the generation of sustainable energy for low temperature devices.

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“…Our research team envisioned the CEC analogy while paying attention to reducing the toxic nature [47]. MMT is a biocompatible substance and widely used for many applications such as pharmaceuticals [48,49], medicines, drugs [50,51], organo-clay [52,53] and nanoclay [54,55].…”

Section: Introductionmentioning

confidence: 99%

The Intercalation of CORM-2 with Pharmaceutical Clay Montmorillonite (MMT) Aids for Therapeutic Carbon Monoxide Release

Faizan

Niazi

Muhammad

et al. 2019

IJMS

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The pharmaceutical clay montmorillonite (MMT) is, for the first time, explored as a carbon monoxide-releasing material (CORMat). MMT consists of silicate double layered structure; its exfoliation feature intercalate the CORM-2 [RuCl(μ-Cl)(CO)3]2 inside the layers to suppress the toxicity of organometallic segment. The infrared spectroscopy (IR) confirmed the existence of ruthenium coordinated carbonyl ligand in MMT layers. The energy-dispersive X-ray spectroscopy (EDX) analysis showed that ruthenium element in this material was about 5%. The scanning electron microscopy (SEM) and transmission electron microscope (TEM) images showed that the layer-structure of MMT has been maintained after loading the ruthenium carbonyl segment. Moreover, the layers have been stretched out, which was confirmed by X-ray diffraction (XRD) analysis. Thermogravimetric (TG) curves with huge weight loss around 100–200 °C were attributed to the CO hot-release of ruthenium carbonyl as well as the loss of the adsorbed solvent molecules and the water molecules between the layers. The CO-liberating properties have been assessed through myoglobin assay. The horse myoglobin test showed that the material could be hydrolyzed to slowly release carbon monoxide in physiological environments. The half-life of CO release was much longer than that of CORM-3, and it has an excellent environmental tolerance and slow release effect.

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Montmorillonite clay nanocomposites for drug delivery

Cited by 15 publications

References 90 publications

Study on the Performance of Composite Adsorption of Cu2+ by Chitosan/β-Cyclodextrin Cross-Linked Zeolite

Study on the Performance of Composite Adsorption of Cu2+ by Chitosan/β-Cyclodextrin Cross-Linked Zeolite

Application of Electrically Conducting Nanocomposite Material Polythiophene@NiO/Frt/GOx as Anode for Enzymatic Biofuel Cells

The Intercalation of CORM-2 with Pharmaceutical Clay Montmorillonite (MMT) Aids for Therapeutic Carbon Monoxide Release

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