Montmorillonite K10-Catalyzed Solvent-Free Conversion of Furfural into Cyclopentenones

Bonacci, Sonia; Nardi, Mónica; Costanzo, Paola; Nino, Antonio De; Gioia, Maria Luisa Di; Oliverio, Manuela; Procopio, Antonio

doi:10.3390/catal9030301

Cited by 24 publications

(20 citation statements)

References 80 publications

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“…pretreatment of the catalyst and the use of toluene as a solvent makes the synthetic process unsustainable [91]. Other zeolites have been tested for the synthesis of benzimidazoles, but the experimental procedures do not show selectivity [92][93][94].…”

Section: Resultsmentioning

confidence: 99%

Montmorillonite K10: An Efficient Organo-Heterogeneous Catalyst for Synthesis of Benzimidazole Derivatives

et al. 2020

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The use of toxic solvents, high energy consumption, the production of waste and the application of traditional processes that do not follow the principles of green chemistry are problems for the pharmaceutical industry. The organic synthesis of chemical structures that represent the starting point for obtaining active pharmacological compounds, such as benzimidazole derivatives, has become a focal point in chemistry. Benzimidazole derivatives have found very strong applications in medicine. Their synthesis is often based on methods that are not convenient and not very respectful of the environment. A simple montmorillonite K10 (MK10) catalyzed method for the synthesis of benzimidazole derivatives has been developed. The use of MK10 for heterogeneous catalysis provides various advantages: the reaction yields are decidedly high, the work-up procedures of the reaction are easy and suitable, there is an increase in selectivity and the possibility of recycling the catalyst without waste formation is demonstrated. The reactions were carried out in solvent-free conditions and in a short reaction time using inexpensive and environmentally friendly heterogeneous catalysis. It has been shown that the reaction process is applicable in the industrial field.

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Section: Resultsmentioning

confidence: 99%

Montmorillonite K10: An Efficient Organo-Heterogeneous Catalyst for Synthesis of Benzimidazole Derivatives

et al. 2020

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“…Hydrogenation of furfural in a flow through mode was performed using a 10 cm 3 reactor, in which a catalyst weighing 2.6 g (fraction size 0.25-0.50 mm) was placed and activated in a stream of hydrogen (300 mL/min) at 250 • C for 1 h. At the end of the reduction, the reactor was cooled, after which the reaction parameters were set: Reaction temperature (100-160 • C), hydrogen pressure 5.0 MPa, and furfural feed rate 3-6 mL/h using a liquid pump ("Kvarta", Novosibirsk, Russia). Samples were done every hour through the sampler.…”

Section: Catalytic Activity Testsmentioning

confidence: 99%

“…The production of motor fuels components and valuable chemical compounds requires the development and improvement of catalytic processes that effectively transform non-edible plant-based raw materials into various products under modern challenges. One of the most promising starting materials is furfural, which can be considered as a platform for the production of a large number of compounds with different properties and a wide range of applications [1][2][3][4]. Furfural widely used as a solvent for dienes extraction in petrochemicals, for solid resins and furacilinum production, in the synthesis of amino cyclopentenones in water that could be applied as intermediates for antitumor products [5,6].…”

Section: Introductionmentioning

confidence: 99%

Highly Active CuFeAl-containing Catalysts for Selective Hydrogenation of Furfural to Furfuryl Alcohol

et al. 2019

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CuFe-containing catalysts with different copper oxide content were prepared by fusion of metal salts. The obtained catalyst showed high activity in the hydrogenation of furfural to furfuryl alcohol (FA) in the batch reactor in the presence of isopropanol as a solvent at a temperature of 100 °C and a hydrogen pressure of 6.0 MPa. The yield of FA and furfural conversion are 97% and 98%, respectively. In the solvent-free reaction in the flow-type reactor; the most active catalyst Cu20Fe66Al14 leads to the 96% formation of FA with 100% conversion of furfural at liquid hourly space velocity (LHSV) = 1 h−1; 160 °C and a hydrogen pressure of 5.0 MPa during 30 h. According to the X-ray diffraction (XRD) method, the active component of the spent and fresh Cu20Fe66Al14 catalyst is the same and is represented by metallic copper and Fe3O4-type spinel. Using different methods, the formation of active sites was investigated.

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“…Motor fuel components and fine chemicals can be produced from non-edible plant-based feedstocks using catalytic processes. Among all available starting materials, furfural is one of the most promising compounds, as it is a platform molecule for the synthesis of a high number of chemicals for a wide range of applications [1][2][3][4]. Furfural production is based on acid hydrolysis of hemicellulose [5].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Furfuryl Alcohol from Furfural: A Comparison between Batch and Continuous Flow Reactors

et al. 2020

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Furfural is a platform molecule obtained from hemicellulose. Among the products that can be produced from furfural, furfuryl alcohol is one of the most extensively studied. It is synthesized at an industrial scale in the presence of CuCr catalyst, but this process suffers from an environmental negative impact. Here, we demonstrate that a non-noble metal catalyst (Co/SiO2) was active (100% conversion of furfural) and selective (100% selectivity to furfuryl alcohol) in the hydrogenation of furfural to furfuryl alcohol at 150 °C under 20 bar of hydrogen. This catalyst was recyclable up to 3 cycles, and then the activity decreased. Thus, a comparison between batch and continuous flow reactors shows that changing the reactor type helps to increase the stability of the catalyst and the space-time yield. This study shows that using a continuous flow reactor can be a solution to the catalyst suffering from a lack of stability in the batch process.

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Montmorillonite K10-Catalyzed Solvent-Free Conversion of Furfural into Cyclopentenones

Cited by 24 publications

References 80 publications

Montmorillonite K10: An Efficient Organo-Heterogeneous Catalyst for Synthesis of Benzimidazole Derivatives

Montmorillonite K10: An Efficient Organo-Heterogeneous Catalyst for Synthesis of Benzimidazole Derivatives

Highly Active CuFeAl-containing Catalysts for Selective Hydrogenation of Furfural to Furfuryl Alcohol

Synthesis of Furfuryl Alcohol from Furfural: A Comparison between Batch and Continuous Flow Reactors

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