Mood and emotional disorders associated with parkinsonism, Huntington disease, and other movement disorders

Bono, Amanda D; Twaite, Jamie T.; Krch, Denise; McCabe, David; Scorpio, Kerri A; Stafford, Remington J.; Borod, Joan C.

doi:10.1016/b978-0-12-822290-4.00015-3

Cited by 9 publications

(16 citation statements)

References 231 publications

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“…These were individuals whose neurologists had not yet established clear diagnoses but suspected atypical parkinsonian syndromes. We decided to include patients with parkinsonism because of the high prevalence of anxiety and mood manifestations in atypical parkinsonian syndromes such as PSP and DLB (Bono et al, 2021 ; Coughlin & Litvan, 2020 ; Tampi et al, 2019 ). There can be early diagnostic uncertainty before idiopathic PD is confirmed, especially for patients presenting with gait abnormality or atypical features (Breen et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Online Mindfulness-Based Cognitive Therapy for People with Parkinson’s Disease and Their Caregivers: a Pilot Study

Seritan

Iosif

Prakash

et al. 2022

J. technol. behav. sci.

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Anxiety and depression are common non-motor symptoms of Parkinson’s disease (PD). Caregivers of people with PD may experience severe caregiver burden. This study explored the feasibility and potential benefits of an online mindfulness-based cognitive therapy (MBCT) intervention for improving anxiety and depressive symptoms in people with PD and their caregivers (ClinicalTrials.gov NCT04469049, 7/8/2020). People with PD or parkinsonism and anxiety and/or depressive symptoms and caregivers of people with PD participated in one of three online MBCT groups. Demographic variables, pre- and post-MBCT behavioral measures (GAD-7, PHQ-9, Five Facet Mindfulness Questionnaire — FFMQ-15, Caregiver Self-Assessment Questionnaire — CSAQ), and satisfaction surveys were collected. Descriptive statistics were used to summarize data. Pre- and post-MBCT behavioral scores were compared using mixed-effect models. Fifty-six potential participants were assessed for eligibility. Twenty-eight entered MBCT groups; all but one completed the intervention. The overall sample analyzed (22 people with PD, 4 caregivers) showed significant GAD-7 and PHQ-9 score reductions and FFMQ-15 total and observing and non-reactivity subscale score increases (all p ’s < 0.05). Participants with PD and anxiety symptoms ( n = 14) had a significant GAD-7 score reduction; those with PD and depressive symptoms ( n = 12) had a significant PHQ-9 score reduction (both p ’s < 0.05). Participants with PD also had a significant FFMQ-15 observing subscale score increase ( p < 0.05). The caregiver sample was too small to be analyzed separately. Online MBCT is feasible (as measured by high attendance, completion rate, and participant satisfaction) and may be effective in improving anxiety and depressive symptoms in people with PD.

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Section: Discussionmentioning

confidence: 99%

Online Mindfulness-Based Cognitive Therapy for People with Parkinson’s Disease and Their Caregivers: a Pilot Study

Seritan

Iosif

Prakash

et al. 2022

J. technol. behav. sci.

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“…48 Dystonia of the facial muscles result in a wooden expression, which is reminiscent of people with parkinsonism who struggle to express emotions with facial musculature. [49][50][51] However, the pathomechanism of the resultant facial expression may not be the same. In horses, a problem seems to occur in facial muscle tone regulation (i.e., dystonia).…”

Section: Stringhalt and Nigropallidal Encephalomalacia In Horsesmentioning

confidence: 99%

“…Chewing‐like jaw movements and dystonia of facial and tongue muscle is a feature of equine nigropallidal encephalomalacia, the plant‐associated toxic encephalopathy also sometimes referred to as equine parkinsonism although it is not the same as Parkinson's disease in humans 48 . Dystonia of the facial muscles result in a wooden expression, which is reminiscent of people with parkinsonism who struggle to express emotions with facial musculature 49‐51 . However, the pathomechanism of the resultant facial expression may not be the same.…”

Section: Movement Disorders In Other Species With Dystonia a Featurementioning

confidence: 99%

Dystonia in veterinary neurology

Santifort

Mandigers

2022

Veterinary Internal Medicne

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Dystonia is a clinical sign and main feature of many movement disorders in humans as well as veterinary species. It is characterized by sustained or intermittent involuntary muscle contractions causing abnormal (often repetitive) movements, postures, or both. This review discusses the terminology and definition of dystonia, its phenomenology, and its pathophysiology, and provides considerations regarding the diagnosis and treatment of dystonia in dogs and cats. In addition, currently recognized or reported disorders in dogs and cats in which dystonia is a particular or main feature are discussed and comparisons are made between disorders featuring dystonia in humans and animals. We suggest that when describing the phenomenology of dogs and cats with dystonia, if possible the following should be included: activity being performed at onset (e.g., resting or running or exercise‐induced), body distribution, duration, responsiveness (subjective), severity, temporal pattern (i.e., paroxysmal or persistent, severity at onset and at later stages), presence or absence of autonomic signs (e.g., salivation), presence or absence of preceding signs (e.g., restlessness), presence or absence of signs after dystonia subsides (e.g., sleepiness), coexistence of other movement disorders, any other neurological manifestations, and possible links to administered medications, intoxications or other associated factors. We also suggest that dystonia be classified based on its etiology as either structural genetic, suspected genetic, reactive, or unknown.

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“…Alterations in emotional processing, particularly in recognition of emotions, have been reported for several types of dementia. 9 , 10 In particular, it is commonly found in patients with behavioral and semantic variants of frontotemporal dementia. 10 , 11 For AD patients, although it is less prominent, studies have reported their difficulty in recognizing emotional expressions across different types of emotions, where it was most pronounced in recognizing “fear” and the least for “surprised.” 12 For DLB, a few studies have suggested deficits in recognizing emotional expressions depending on the type of emotion, for example, diminished recognition of “surprised” faces 13 note that investigations into emotional processing alterations in DLB are still limited.…”

Section: Introductionmentioning

confidence: 99%

“…Contrary to emotional recognition, emotional expression in dementia patients, which is also crucial for social interactions, 9 , 14 , 17 affecting individuals' mental health and quality of life, 9 remains largely uninvestigated. To the best of our knowledge, no study has explored alterations in emotional expressions in DLB or compared with those in AD.…”

Section: Introductionmentioning

confidence: 99%

Vocal expression of emotions discriminates dementia with Lewy bodies from Alzheimer's disease

Kobayashi,

Yamada,

Shinkawa

et al. 2024

Alz & Dem Diag Ass & Dis Mo

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Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD), the two most common neurodegenerative dementias, both exhibit altered emotional processing. However, how vocal emotional expressions alter in and differ between DLB and AD remains uninvestigated. We collected voice data during story reading from 152 older adults comprising DLB, AD, and cognitively unimpaired (CU) groups and compared their emotional prosody in terms of valence and arousal dimensions. Compared with matched AD and CU participants, DLB patients showed reduced overall emotional expressiveness, as well as lower valence (more negative) and lower arousal (calmer), the extent of which was associated with cognitive impairment and insular atrophy. Classification models using vocal features discriminated DLB from AD and CU with an AUC of 0.83 and 0.78, respectively. Our findings may aid in discriminating DLB patients from AD and CU individuals, serving as a surrogate marker for clinical and neuropathological changes in DLB.Highlights DLB showed distinctive reduction in vocal expression of emotions. Cognitive impairment was associated with reduced vocal emotional expression in DLB. Insular atrophy was associated with reduced vocal emotional expression in DLB. Emotional expression measures successfully differentiated DLB from AD or controls.

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Mood and emotional disorders associated with parkinsonism, Huntington disease, and other movement disorders

Cited by 9 publications

References 231 publications

Online Mindfulness-Based Cognitive Therapy for People with Parkinson’s Disease and Their Caregivers: a Pilot Study

Online Mindfulness-Based Cognitive Therapy for People with Parkinson’s Disease and Their Caregivers: a Pilot Study

Dystonia in veterinary neurology

Vocal expression of emotions discriminates dementia with Lewy bodies from Alzheimer's disease

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