Mood and Memory Function in Ovariectomised Rats Exposed to Social Instability Stress

Al-Rahbi, Badriya; Zakaria, Rahimah; Othman, Zahiruddin; Hassan, Asma; Muthuraju, Sangu; Mohammad, Wan Mohd Zahiruddin Wan

doi:10.1155/2013/493643

Cited by 18 publications

(11 citation statements)

References 75 publications

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“…Increases in levels of corticosterone in stressed animals have been seen following other studies using physical stress (Al‐Rahbi et al., 2014), and higher levels of corticosterone were shown to be importantly involved in the negative effect on the animal's subsequent learning and memory and effects were concentration‐dependent (Kovács et al., 1976), suggesting in ovariectomized female rats, corticosterone levels could play a role in learning and memory deficits. In our study, sham‐operated rats did not exhibit a rise in corticosterone upon stressor exposure, which is in contrast to findings that physical stress for two weeks increased blood corticosterone levels in ovarian intact animals, which could be due to differences in duration of the stress, the type of stress, the breed of the animal, or/and the age of the animal between the two studies (Al‐Rahbi et al., 2013).…”

Section: Discussioncontrasting

confidence: 99%

“…Furthermore, modulation of the GR response by ERβ‐mediated signaling can be induced in this nucleus, as ERβ agonists reduced stress‐induced anxiety‐type behaviors and eliminated CORT secretion upon a stressor in the central nucleus of the amygdala (Weiser et al., 2010). In ovariectomized animals which exhibited higher levels of anxiety due to psychological stress compared with sham animals, estrogen attenuated release of CRF, and modulated HPA axis activity through ERβ in the paraventricular nucleus (Al‐Rahbi et al., 2013). One proposed mechanism for estrogen‐mediated reductions in stress‐induced anxiety in overiectamized rats is that ERβ signaling in amygdala reestablishes equilibrium between GABAergic and glutamatergic transmission in the basolateral amygdala through alterations in inhibitory and excitatory receptor up and downregulation (Tian et al., 2013).…”

Section: Discussionmentioning

confidence: 99%

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Estrogen attenuates physical and psychological stress‐induced cognitive impairments in ovariectomized rats

Khaleghi

Rajizadeh

Bashiri³

et al. 2021

Brain and Behavior

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Introduction Women are more vulnerable to stress‐related disorders than men, which is counterintuitive as female sex hormones, especially estrogen, have been shown to be protective against stress disorders. Methods In this study, we investigated whether two different models of stress act differently on ovariectomized (OVX) rats and the impact of estrogen on physical or psychological stress‐induced impairments in cognitive‐behaviors. Adult female Wistar rats at 21–22 weeks of age were utilized for this investigation. Sham and OVX rats were subjected to physical and psychological stress for 1 hr/day for 7 days, and cognitive performance was assessed using morris water maze (MWM) and passive avoidance (PA) tests. The open field and elevated plus maze tests (EPM) evaluated exploratory and anxiety‐like behaviors. Results In sham and OVX rats, both physical and psychological stressors were associated with an increase in EPM‐determined anxiety‐like behavior. OVX rats exhibited decreased explorative behavior in comparison with nonstressed sham rats (p < .05). Both physical stress and psychological stress resulted in disrupted spatial cognition as assayed in the MWM (p < .05) and impaired learning and memory as determined by the PA test when the OVX and sham groups were compared with the nonstressed sham group. Estrogen increased explorative behavior, learning and memory (p < .05), and decreased anxiety‐like behavior compared with vehicle in OVX rats exposed to either type of stressor. Conclusions When taken together, estrogen and both stressors had opposite effects on memory, anxiety, and PA performance in a rat model of menopause, which has important implications for potential protective effects of estrogen in postmenopausal women exposed to chronic stress.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Estrogen attenuates physical and psychological stress‐induced cognitive impairments in ovariectomized rats

Khaleghi

Rajizadeh

Bashiri³

et al. 2021

Brain and Behavior

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“…On the other hand, this spontaneous behaviour was not observed in SD rats, which were shown to be more vulnerable to isolation-induced anxiety and depressive-like behaviours (Weiss et al ., 2000 ). Additionally, anxiety- and depressive-like behaviour were significantly increased in social instability stressed SD females compared to non-stressed ovariectomised rats yet not in sham-operated controls, suggesting a protective role of sex hormones in the development of stress-induced behavioural disorders in females (Al-Rahbi et al ., 2013 ). Thus the effect of stress on open field behaviour depends on many factors and variable results can be observed depending on protocol, strain, sex and age of the subjects tested.…”

Section: Open Field Test: Equipment and Procedures Of Testingmentioning

confidence: 99%

Determination of motor activity and anxiety-related behaviour in rodents: methodological aspects and role of nitric oxide

Sestakova¹,

Púzserová²,

Kluknavsky³

et al. 2013

Interdisciplinary Toxicology

260

139

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In various areas of the bio-medical, pharmacological and psychological research a multitude of behavioural tests have been used to investigate the effects of environmental, genetic and epi-genetic factors as well as pharmacological substances or diseased states on behaviour and thus on the physiological and psycho-social status of experimental subjects. This article is reviewing the most frequently used behavioural tests in animal research (open field, elevated plus maze, zero maze, and black and white box). It provides a summary of common characteristics as well as differences in the methods used in various studies to determine motor activity, anxiety and emotionality. Additionally to methodological aspects, strain, sex and stress-related differences as well as the involvement of nitric oxide in modulation of motor activity and anxiety of rodents were briefly reviewed.

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“…Stress and oestrogen (E2) deficiency are the major contributors in increasing an individual's susceptibility to oxidative stress and affective disorders. Recently, our research group reported increased anxiety-like behavior in stressed ovariectomized (OVX) rats compared with nonstressed OVX or stressed sham-operated controls [ 14 ]. It was suggested that high circulating corticosterone acts synergistically with low circulating E2 to exert negative effects on the mood.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Tualang Honey against Oxidative Stress and Anxiety-Like Behaviour in Stressed Ovariectomized Rats

Al-Rahbi¹,

Zakaria

Othman

et al. 2014

International Scholarly Research Notices

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The present study aims to evaluate the antioxidant and anxiolytic-like effect of Tualang honey in stressed ovariectomized (OVX) rats. The animals were divided into; (i) nonstressed sham-operated control rats, (ii) sham-operated control rats exposed to stress, (iii) nonstressed OVX rats, (iv) OVX rats exposed to stress, (v) OVX rats exposed to stress and treated with 17 β-oestradiol (E2) (20 μg daily, sc), and (vi) OVX rats exposed to stress and treated with Tualang honey (0.2 g/kg body weight, orally). The open field test was used to evaluate the anxiety-like behaviour and ELISA kits were used to measure oxidant/antioxidant status of the brain homogenates. The result showed that anxiety-like behavior was significantly increased in stressed OVX compared to other groups, and administering either E2 or Tualang honey significantly decreased anxiety-like behaviour in stressed OVX rats. The levels of malondialdehyde (MDA) and protein carbonyl (PCO) were significantly decreased while the levels/activities of superoxide dismutase (SOD), glutathione S-transferases (GST), glutathione peroxidase (GPx), and glutathione reductase (GR) were significantly increased in the brain homogenates of treated stressed OVX groups compared to untreated stressed OVX. In conclusion, Tualang honey has protective effects against brain oxidative stress and may be useful alternative anxiolytic agent especially for postmenopausal women.

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Mood and Memory Function in Ovariectomised Rats Exposed to Social Instability Stress

Cited by 18 publications

References 75 publications

Estrogen attenuates physical and psychological stress‐induced cognitive impairments in ovariectomized rats

Estrogen attenuates physical and psychological stress‐induced cognitive impairments in ovariectomized rats

Determination of motor activity and anxiety-related behaviour in rodents: methodological aspects and role of nitric oxide

Protective Effects of Tualang Honey against Oxidative Stress and Anxiety-Like Behaviour in Stressed Ovariectomized Rats

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