Mood, anxiety, and perceived quality of life in adults with epilepsy and intellectual disability

Snoeijen‐Schouwenaars, Francesca M.; Ool, Jans S. van; Tan, In Y.; Aldenkamp, Albert P.; Schelhaas, Helenius J.; Hendriksen, Jos G.M.

doi:10.1111/ane.13085

Cited by 11 publications

(16 citation statements)

References 29 publications

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“…Decreased hippocampal neurogenesis was demonstrated in rodent models of anxiety, and anxiolytic medications were found to increase hippocampal neurogenesis in both rodents and humans [32, 33]. It was reported that anxiety can dramatically influence the quality of life of patients with EP [34, 35]. Postoperative anxiety was observed in about 9% of patients who underwent ANT-DBS for the treatment of drug-resistant EP [7, 36, 37].…”

Section: Discussionmentioning

confidence: 99%

The Role of Hippocampal Neurogenesis in ANT-DBS for LiCl-Pilocarpine-Induced Epileptic Rats

Tang¹,

He²,

Feng³

et al. 2020

Stereotact Funct Neurosurg

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Purpose: Abnormal neurogenesis in the hippocampus after status epilepticus (SE) has been suggested as a key pathogeny of temporal lobe epilepsy. This study aimed to investigate the effect of deep brain stimulation of the anterior thalamic nucleus (ANT-DBS) on hippocampal neurogenesis in LiCl-pilocarpine-induced epileptic rats and to analyze its relationship with postoperative spontaneous recurrent seizures (SRS) and anxiety. Method: SE was induced by a systemic LiCl-pilocarpine injection in adult male rats. Rats in the DBS group underwent ANT-DBS immediately after successful SE induction. SRS was only recorded during the chronic stage. An elevated plus maze was used to evaluate the level of anxiety in rats 7, 28, and 60 days after SE onset. After the elevated plus-maze experiment, rats were sacrificed under anesthesia in order to evaluate hippocampal neurogenesis. Doublecortin (DCX) was used as a marker for neurogenesis. Results: During the chronic stage, SRS in rats in the DBS group were significantly decreased. The level of anxiety was increased significantly in rats in the DBS group 28 days after SE, while no significant differences in anxiety levels were found 7 and 60 days after SE. The number of DCX-positive cells in the hippocampus was significantly increased 7 days after SE and was significantly decreased 60 days after SE in all rats in which SE was induced. However, the number of DCX-positive cells in the DBS group was significantly lower than that in the other groups 28 days after SE. Conclusions: ANT-DBS may suppress SRS and increase the postoperative anxiety of epileptic rats by influencing hippocampal neurogenesis.

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Section: Discussionmentioning

confidence: 99%

The Role of Hippocampal Neurogenesis in ANT-DBS for LiCl-Pilocarpine-Induced Epileptic Rats

Tang¹,

He²,

Feng³

et al. 2020

Stereotact Funct Neurosurg

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“…None reported a significant association. 32,37,50,58 On the other hand, epileptic activity was significantly associated with overall psychiatric disorders in two studies. 25,30 One study 32 showed a significantly higher rate of psychiatric disorders in the active epilepsy group (seizure in the past 12 months) than the non-epilepsy control group.…”

Section: Association Between Psychiatric Disorders and Epilepsy-related Variablesmentioning

confidence: 93%

“…Included studies used different methods to diagnose intellectual disabilities and evaluate severity. Six studies 11,25,30,[35][36][37] used standardised evaluation of intellectual disabilities with various psychometric tests, such as Wechsler Adult Intelligence Scale 38 and Vineland Adaptive Behaviour Scales. 39,40 Six studies referred to ICD criteria for intellectual disabilities diagnosis, with one study 32 referring to the eighth edition, 41 one study 42 referring to the ninth edition 43 and four studies 27,29,33,44 referring to the tenth edition.…”

Section: Intellectual Disabilitiesmentioning

confidence: 99%

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Association between epilepsy and psychiatric disorders in adults with intellectual disabilities: systematic review and meta-analysis

2021

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Background Psychiatric disorders, such as depression and anxiety, are commonly associated with epilepsy in the general population, but the relationship between psychiatric disorders and epilepsy among adults with intellectual disabilities is unclear. Aims To conduct a systematic review and meta-analysis to assess whether epilepsy is associated with an increased rate of psychiatric disorders in adults with intellectual disabilities. Method We included literature published between 1985 and 2020 from four databases, and hand-searched six relevant journals. We assessed risk of bias by using SIGN 50 and the Cochrane risk of bias tool. Several meta-analyses were carried out. Results We included 29 papers involving data on 9594 adults with intellectual disabilities, 3180 of whom had epilepsy and 6414 did not. Of the 11 controlled studies that compared the overall rate of psychiatric disorders between the epilepsy and non-epilepsy groups, seven did not show any significant inter-group difference. Meta-analysis was possible on pooled data from seven controlled studies, which did not show any significant inter-group difference in the overall rate of psychiatric disorders. The rates of psychotic disorders, depressive disorders and anxiety disorders were significantly higher in the non-epilepsy control groups compared with the epilepsy group, with effect sizes of 0.29, 0.47 and 0.58, respectively. Epilepsy-related factors did not show any definite association with psychiatric disorders. Conclusions It is difficult to pool data from such heterogeneous studies and draw any definitive conclusion because most studies lacked an appropriately matched control group, which will be required for future studies.

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“…Increasing evidences have indicated that depression and epilepsy such as temporal lobe epilepsy (TLE) represent an epiphenomenon sharing similar neural networks [7]. Mental health was related to poorer quality of life and worse prognosis in people with epilepsy [8][9][10]. These psychiatric comorbidities have a huge burden on patients, families and society [11].…”

Section: Introductionmentioning

confidence: 99%

A cross-sectional study on the association of serum uric acid levels with depressive and anxiety symptoms in people with epilepsy

Zhong

Chen

et al. 2021

BMC Psychiatry

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Background High serum uric acid (SUA) levels may provide protection against depression and anxiety through its defensive role in oxidative damage. The aim of this study was to test the hypothesis of the independent associations of lower SUA levels with depressive and anxiety symptoms among patients with epilepsy (PWE). Methods A cross-sectional study was performed among 320 PWE aged ≥18 years old in Northeast China. The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E; Chinese version) and the Generalized Anxiety Disorder-7 scale (GAD-7; Chinese version) were used as screening tools for depressive and anxiety symptoms for PWE. Serum uric acid levels were measured. The associations of SUA levels with depressive and anxiety symptoms were assessed by using binary logistic regression models, with adjustment for the related risk factors (P< 0.05). Results Lower SUA tertiles were significantly associated with higher C-NDDI-E and GAD-7 scores compared with the higher two tertiles (p=0.001, and p= 0.002). Patients with depressive symptoms exhibited significantly lower SUA levels compared to those without depressive symptoms (p< 0.001). SUA levels of patients with anxiety symptoms were significantly lower than those of patients without anxiety symptoms (p< 0.001). The first and second SUA tertiles were associated with depressive symptoms, with the third tertile group as the reference group, after adjusting for confounders (first tertile: OR = 4.694, 95% CI = 1.643~ 13.413, P = 0.004; second tertile: OR = 3.440, 95% CI = 1.278~9.256, P = 0.014). However, The first and second SUA tertiles were not associated with the risk of anxiety symptoms compared with the third tertile in the adjusted logistic regression model (First tertile: OR = 1.556, 95% CI = 0.699~3.464, P = 0.279; second tertile: OR = 1.265, 95% CI = 0.607~2.635, P = 0.530). Conclusion We found that lower SUA levels were independently associated with depressive symptoms but not with anxiety symptoms among PWE. Further well-designed prospective cohort studies are required to determine the causality of the associations and to further clarify the mechanisms of SUA in depressive symptoms.

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Mood, anxiety, and perceived quality of life in adults with epilepsy and intellectual disability

Cited by 11 publications

References 29 publications

The Role of Hippocampal Neurogenesis in ANT-DBS for LiCl-Pilocarpine-Induced Epileptic Rats

The Role of Hippocampal Neurogenesis in ANT-DBS for LiCl-Pilocarpine-Induced Epileptic Rats

Association between epilepsy and psychiatric disorders in adults with intellectual disabilities: systematic review and meta-analysis

A cross-sectional study on the association of serum uric acid levels with depressive and anxiety symptoms in people with epilepsy

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