Mood disorders and non-celiac gluten sensitivity

Casella, Giovanni; Pozzi, Roberta; Cigognetti, Marta; Bachetti, Francesco; Torti, Gabriele; Cadei, Moris; Villanacci, Vincenzo; Baldini, Vittorio; Bassotti, Gabrio

doi:10.23736/s1121-421x.16.02325-4

Cited by 12 publications

(5 citation statements)

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“…Nos últimos anos, tem havido um interesse crescente pelas dietas nutricionais, que podem ser utilizadas como uma forma de intervenção terapêutica para as patologias do SNC, bem como como profilaxia das mesmas 34 . Os nutrientes presentes nos alimentos podem tanto, auxiliar de forma adjuvante as terapias de processos patológicos do SNC, como por exemplo, alimentos ricos em L-triptofano serem indicados para os casos de depressão 35 , quanto podem ser os protagonistas no desenvolvimento de algumas disfunções neurológicas, e o glúten se encaixa nessa suposição 14 .…”

Section: Discussionunclassified

Estudo da influência do glúten sobre parâmetros comportamentais e bioquímicos em animais submetidos a modelos de doenças neuropsiquiátricas

Souza,

Krutzsch,

Pires Viana Silva

et al. 2023

R. Assoc. bras. Nutr.

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A presença de glúten na dieta pode ser desencadeante de vários processos fisiopatológicos que culminam em doenças neuropsiquiátricas além dos problemas gastrointestinais. Nos chamados “sensíveis ao glúten não celíacos”, os dados da literatura são divergentes. Objetivo: avaliar o efeito dos tratamentos de diferentes dietas relacionadas ao teor de glúten, sobre parâmetros comportamentais e bioquímicos. Métodos: camundongos C56bl/6j (fêmeas, N:7-10) foram submetidos a testes comportamentais de doenças neuropsiquiátricas. Os animais foram divididos em grupos: G1/ ração enriquecida 75% de glúten (DEG), G2/dieta normal (Nuvilab®- DNN) e G3/dieta isenta de glúten (DIG). Para os testes de depressão e ansiedade, foram introduzidos dois grupos adicionais (controles – positivos) que receberam respectivamente Fluoxetina (20mg/kg mg), Diazepam (0.75mg/kg e galantamina (4mg kg/kg). Após o período de tratamento os animais foram submetidos aos testes comportamentais: Open field (Campo aberto), Suspensão pela cauda (TSC), labirinto em cruz elevada (LCE) e esquiva inibitória (TEI). Foram realizados ensaios bioquímicos para verificar a influência da DEG sobre os parâmetros bioquímicos (ALT, AST, glicose de jejum, colesterol total, HDL, TG). Resultados: Os resultados demonstraram que DEG desencadeou comportamentos de ansiedade e depressão nos animais, além de déficits de memória. Promoveu também hiperglicemia, aumento do peso corporal, diminuição do HDL e aumento do LDL. Podendo levar à um mau funcionamento das funções hepáticas (AST e ALT). Conclusão: Os resultados em conjunto confirmam os efeitos deletérios causado pelo glúten. Palavras-chave: Glúten. Depressão. Ansiedade. Memória. Ensaios pré-clinicos. Camundongos.

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Section: Discussionunclassified

Estudo da influência do glúten sobre parâmetros comportamentais e bioquímicos em animais submetidos a modelos de doenças neuropsiquiátricas

Souza,

Krutzsch,

Pires Viana Silva

et al. 2023

R. Assoc. bras. Nutr.

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“…Several neurological symptoms and alterations of the peripheral or central nervous system have been reported in untreated CeD patients, such as peripheral neuropathies, epilepsy, cerebellar ataxia, migraine, and cognitive impairment [ 71 ]. These conditions can be the only manifestations of CeD and are often under-recognized [ 72 ]. Updates on the relevant neurological manifestations of CeD have been presented by Patel et al [ 73 ] and Gala et al [ 74 ].…”

Section: Nervesmentioning

confidence: 99%

Associations between Celiac Disease, Extra-Gastrointestinal Manifestations, and Gluten-Free Diet: A Narrative Overview

Santonicola,

Wieser,

Gizzi

et al. 2024

Nutrients

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Millions of children and adults worldwide suffer from undiagnosed and untreated celiac disease (CeD). The clinical picture of CeD is highly heterogeneous and comprises manifestations that can affect almost the whole body. This narrative overview is aimed at characterizing diseases and complaints that are associated with unrecognized CeD and that frequently involve sites other than the gastrointestinal (G.I.) tract, i.e., dental, otorhinolaryngological, and ocular complications; skin and hair abnormalities; afflictions of the bones, joints, and muscles; cardiovascular affectations; kidney diseases; neuro-psychiatric disorders; and gynecological–obstetrical manifestations. The association between CeD and extra-GI manifestations is frequently overlooked, which leads to a delay in diagnosis. Most CeD-mediated disorders can be treated with a strict gluten-free diet (GFD), but some of them are irreversible unless CeD is diagnosed in time. Some manifestations can be classified as risk factors for CeD, and CeD screening tests for affected patients should be selectively considered. Apart from gastroenterologists, specialists in other medical disciplines can play an important role in identifying people with unrecognized CeD and may help prevent its progress and long-term complications. Further comprehensive investigations are necessary to clarify the pathogenesis of extra-GI manifestations and the effect of a GFD.

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“…An interferon-free therapy or gluten-free based can be considered if the TGA is positive before beginning the treatment. However, because of the lack of a link between the two diseases, the screening of CD cannot be recommended [52]. Several studies have failed to find a relationship between HCV or polyethylene glycol Interferon-α and CD.…”

Section: Hepatitis C Virus [Hcv]mentioning

confidence: 99%

Viruses and celiac disease: what do we know ?

et al. 2023

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The aim of this review is to provide a comprehensive overview about the link between viruses and celiac disease. A systematic search on PubMed, Embase, and Scopus was conducted on March 07, 2023. The reviewers independently selected the articles and chose which articles to include. The review is a textual systemic review, and all relevant articles were included based on title and abstract. If there was a disagreement between the reviewers, they came to a consensus during deliberation sessions. A total of 178 articles were selected for the review and read in full; only part of them was retained. We found studies between celiac disease and 12 different viruses. Some of the studies were done only on small groups. Most studies were on pediatric population. Evidence for an association was found with several viruses (trigger or protective). It seems that only a part of the viruses could induce the disease. Several points are important to keep in mind: firstly, simple mimicry or that the virus induces a high level of TGA is not sufficient to promote the disease. Secondly, inflammatory background is necessary to induce CD with virus. Thirdly, IFN type 1 seems to have an important role. Some of the viruses are potential or known triggers like enteroviruses, rotaviruses, reoviruses, and influenza. Further studies are needed to better understand the role of viruses in celiac disease to better treat and prevent the disease.

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Mood disorders and non-celiac gluten sensitivity

Cited by 12 publications

References 0 publications

Estudo da influência do glúten sobre parâmetros comportamentais e bioquímicos em animais submetidos a modelos de doenças neuropsiquiátricas

Estudo da influência do glúten sobre parâmetros comportamentais e bioquímicos em animais submetidos a modelos de doenças neuropsiquiátricas

Associations between Celiac Disease, Extra-Gastrointestinal Manifestations, and Gluten-Free Diet: A Narrative Overview

Viruses and celiac disease: what do we know ?

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