Mood disorders comorbidity in obese bariatric patients: the role of the emotional dysregulation

Barbuti, Margherita; Carignani, Giulia; Weiss, Francesco; Calderone, Alba; Santini, Ferruccio; Perugi, Giulio

doi:10.1016/j.jad.2020.09.128

Cited by 19 publications

(21 citation statements)

References 51 publications

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“…Similarly to most of the previous reports [10,[17][18][19][20][21][22][23][24][25], almost three-quarters of the sample were women, the mean age was 45 years, and the vast majority of patients belonged to class III obesity. Overall, the sample showed a lower level of education than the general population in Italy [26].…”

Section: Discussionsupporting

confidence: 75%

Prevalence of mood, panic and eating disorders in obese patients referred to bariatric surgery: patterns of comorbidity and relationship with body mass index

et al. 2021

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Purpose We aimed at investigating the lifetime prevalence of mood, eating and panic disorders in a large sample of obese patients referred to bariatric surgery. We also explored the patterns of psychiatric comorbidity and their relationship with Body Mass Index (BMI). Methods The sample was composed of patients consecutively referred for pre-surgical evaluation to the Obesity Center of Pisa University Hospital between January 2004 and November 2016. Clinical charts were retrieved and examined to obtain sociodemographic information, anthropometric variables and lifetime psychiatric diagnoses according to DSM-IV criteria. Results A total of 871 patients were included in the study; 72% were females, and most patients had BMI ≥ 40 kg/m2 (81%). Overall, 55% of the patients were diagnosed with at least one lifetime psychiatric disorder. Binge eating disorder (27.6%), major depressive disorder (16%), bipolar disorder type 2 (15.5%), and panic disorder (16%) were the most common psychiatric diagnoses. Mood disorders showed associations with panic disorder (OR = 2.75, 95% CI = 1.90–3.99, χ2 = 41.85, p = 0.000) and eating disorders (OR = 2.17, 95% CI 1.64–2.88, χ2 = 55.54, p = 0.000). BMI was lower in patients with major depressive disorder (44.9 ± 7.89) than in subjects without mood disorders (46.75 ± 7.99, padj = 0.017). Conclusion Bariatric patients show high rates of psychiatric disorders, especially binge eating and mood disorders. Longitudinal studies are needed to explore the possible influence of such comorbidities on the long-term outcome after bariatric surgery. Level of evidence V, cross sectional descriptive study.

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Section: Discussionsupporting

confidence: 75%

Prevalence of mood, panic and eating disorders in obese patients referred to bariatric surgery: patterns of comorbidity and relationship with body mass index

et al. 2021

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“…8 The relationship between obesity and mental health is bidirectional. 3,[9][10][11] Psychological disorders, and their treatments, increase the risk of developing obesity and co-occurring diseases. 3,10,11 For example, adolescents with mental disorders report higher intake of unhealthy foods and reduced physical activity leading to increased risk of obesity.…”

Section: Introductionmentioning

confidence: 99%

“…3,[9][10][11] Psychological disorders, and their treatments, increase the risk of developing obesity and co-occurring diseases. 3,10,11 For example, adolescents with mental disorders report higher intake of unhealthy foods and reduced physical activity leading to increased risk of obesity. 10 Concurrently, the brain is a glycogen-dependent organ with high metabolic demand, and multiple pathologies have been correlated with altered metabolism and metabolic pathology within the brain.…”

Section: Introductionmentioning

confidence: 99%

Obesogenic diets induce anxiety in rodents: A systematic review and meta‐analysis

2021

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Obesity and mood disorders have been linked in a positive feedback loop. However, due to the bidirectional relationship between obesity and mental health, it is not clear whether anxiety is correlated with or caused by consumption of obesogenic diets.Here, we present a meta-analysis on the effects of dietary manipulation on rodent behavior in the elevated plus maze and open field test, the most common tests of anxiety-like behavior in animal models. The main dataset examined effects of obesogenic diets on time spent in the open and movement around the mazes. Auxiliary datasets examined effects of caloric restriction and protein restriction.Obesogenic diets had a negative effect on the time spent in the open overall. Effects were stronger in males than females. No effect of diet on locomotion was found, indicating that increases in anxiety-like behavior are not due to altered activity levels.No consistent effect of caloric restriction was observed, whereas protein restriction was associated with an increase in the time spent in the open. We show that obesogenic diets have a causative effect on anxiety-like behaviors in rodents, and not via a change in activity. Further studies are required to determine why obesogenic diets induce these behavioral changes.

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“…Obesity closely relates to various diseases that threaten human health. It can make people depressed, have low self‐esteem, and result in lower living standards 2 . It is a factor to cause stroke, 3 hypertension, 4 asthma, 5 degenerative osteoarthritis, 6 non‐alcoholic fatty liver disease, 7 breast and uterine cancers, 8 diabetes 9 .…”

Section: Introductionmentioning

confidence: 99%

Binding mechanism of lipase with Lentinus edodes mycelia polysaccharide by multi‐spectroscopic methods

Liu

Chen

et al. 2021

J of Molecular Recognition

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It is an effective strategy to avoid obesity by inhibiting the activity of lipase. In this study, the binding mechanism of lipase and Lentinus edodes mycelia polysaccharide (LMP) were explored with multi‐spectral methods, for example, three‐dimensional (3D) fluorescence, Fourier‐transformed infrared (FT‐IR), and Raman spectra. At 290 K, the binding constant was 2.44 × 105 L/mol, there was only one binding site between LMP and lipase. Static quenching was the quenching mechanism. The major forces were hydrogen bonding and van der Waals force. The binding of LMP to lipase impacted the microenvironment around tyrosine and tryptophan residues. The polarity around these residues was decreased and hydrophobicity was enhanced. This study not only revealed the binding mechanism of LMP on lipase but also provided scientific evidence for expanding the application of LMP in functional food industries.

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Mood disorders comorbidity in obese bariatric patients: the role of the emotional dysregulation

Cited by 19 publications

References 51 publications

Prevalence of mood, panic and eating disorders in obese patients referred to bariatric surgery: patterns of comorbidity and relationship with body mass index

Prevalence of mood, panic and eating disorders in obese patients referred to bariatric surgery: patterns of comorbidity and relationship with body mass index

Obesogenic diets induce anxiety in rodents: A systematic review and meta‐analysis

Binding mechanism of lipase with Lentinus edodes mycelia polysaccharide by multi‐spectroscopic methods

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