Mood disorders in familial epilepsy: A test of shared etiology

Abstract

SummaryObjective: Mood disorders are the most common comorbid conditions in epilepsy, but the cause remains unclear. One possible explanation is a shared genetic susceptibility to epilepsy and mood disorders. We tested this hypothesis by evaluating lifetime prevalence of mood disorders in relatives with and without epilepsy in families containing multiple individuals with epilepsy, and comparing the findings with rates from a general population sample. relative with FE. Compared with general population rates, mood disorders were significantly increased in individuals with FE but not in those with GE. Rates were also increased in RWOE, but not significantly so (SPR = 1.4, P = .14). Significance: These findings are consistent with the hypothesis of shared genetic susceptibility to epilepsy and mood disorders, but suggest (1) the effect may be restricted to FE, and (2) the shared genetic effect on risk of mood disorders and epilepsy may be restricted to individuals with epilepsy, that is, to those in whom the genetic risk for epilepsy is "penetrant."

Common mental illness among epilepsy patients in Bahir Dar city, Ethiopia: A cross-sectional study

“…At last, the quality of life is likely to be worse in epilepsy patients with common mental disorders [39]. The present study showed that a family history of epilepsy was associated with mental illness which is consistent with other studies [40,41]. The commonest (27%) risk factors identified in the hospital-based retrospective study in Saudi Arabia was the presence of a family history of epilepsy [42].…”

“…Moreover, epilepsy and mental illness may share a common genetic predisposition. This is supported by the magnitude of mood disorders that were found high among people living with epilepsy who had a relative with focal epilepsy [41]. Common mental disorders found to be higher in epilepsy patients and people with common mental disorders have been more likely to suffer from epilepsy [39].…”

Epilepsy and psychotic symptoms

“…Las comorbilidades psiquiátricas, incluidos los trastornos del estado de ánimo (3) , la ansiedad (4) y los trastornos psicóticos (5) , son frecuentes en la epilepsia y, a menudo, ocurren en tasas de 2 a 3 veces o más que en la población general sin epilepsia. Considerando los diferentes tipos de psicosis, las psicosis interictales representan en algunas publicaciones un 5,2 % de los casos, las que corresponden a epilepsias del lóbulo temporal corresponden al 7 % y las psicosis postictales al 2 % (6) .…”

Recent Studies on Anti-Depressant Bioactive Substances in Selected Species from the Genera Hemerocallis and Gladiolus: A Systematic Review

“…Evidence has been found that seizures and mood disorders, including depression, may share the same genetic cause in some epilepsy patients. It is believed that modern antidepressants (SSRI, SNRI, noradrenergic, and specific serotonergic antidepressant-NaSSA) can be safely used in epilepsy; however, due to the lack of relevant studies, the evidence is still incomplete, especially in the case of mild depression [257][258][259][260][261][262][263][264][265][266][267][268][269][270][271]. The current knowledge of the biochemical and structural background of depression is wide, and the issue has been sufficiently recognized.…”