Mood disturbance versus other symptoms of depression in multiple sclerosis

Nyenhuis, David L.; Rao, Stephen M.; Zajecka, John; Luchetta, Tracy; Bernardin, Linda; Garron, David C.

doi:10.1017/s135561770000028x

Cited by 135 publications

(120 citation statements)

References 20 publications

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“…Data from the study supported the concurrent and discriminative validity of the BDI-FS, which indicates that the test did not confound MS-related neurological symptoms. The Chicago Multiscale Depression Inventory is an alternative short instrument that was developed for assessing depression in patients with MS [84]. It was found to have good internal consistency, sensitivity, and construct validity [4].…”

Section: Assessment Of Depressionmentioning

confidence: 99%

Depression and multiple sclerosis: Review of a lethal combination

Wallin¹,

Wilken

Turner

et al. 2006

JRRD

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Abstract-Depression is the most frequent psychiatric disorder in multiple sclerosis (MS) patients. The etiology of depression is multifactorial and likely associated with psychosocial stress, focal demyelinating lesions, and immune dysfunction. Proper diagnosis and severity assessment are critical prior to initiation of therapy. Patients with suicidal ideation should be referred for immediate psychiatric consultation and be closely monitored. While more therapeutic trials for depression in MS are needed, MS patients have been shown to respond to current antidepressant medications and psychotherapy. Unfortunately, patients with MS and major depression or suicidal thoughts are often underassessed and therefore not diagnosed. Unlike other aspects of MS, depression is treatable. Early intervention in depression can prevent declines in quality of life and even death from suicide. This article reviews the unique features, assessment, and treatment of depression in MS. MS care providers should vigilantly assess depression and suicide risk in their patients.

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Section: Assessment Of Depressionmentioning

confidence: 99%

Depression and multiple sclerosis: Review of a lethal combination

Wallin¹,

Wilken

Turner

et al. 2006

JRRD

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“…Some researchers contend that assessment of depression in MS, particularly by self-report, is complicated by overlap between symptoms of depression and MS symptoms like fatigue, sleep disturbance, and sexual dysfunction (Mohr et al, 1997;Nyenhuis et al, 1995Nyenhuis et al, , 1998. Whereas it is known that some symptoms of MS are also symptoms of depression, and authors frequently discuss such overlap as a settled question (e.g., Goldman Consensus Group, 2005), there does not seem to be clear evidence of such overlap presenting a problem for assessment.…”

Section: Introductionmentioning

confidence: 99%

Endorsement of self-report neurovegetative items of depression is associated with multiple sclerosis disease symptoms

Beeney

Arnett

2008

J Int Neuropsychol Soc

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Some researchers have suggested that general self-report depression scales may be inadequate for assessing depression among individuals with Multiple Sclerosis (MS), because many of such items represent MS disease symptoms. However, research has been mixed on this issue: whereas some studies provide support for symptom overlap, others have found opposing evidence. We investigated this issue in two different MS samples with three different strategies. We (1) examined reliable change in depression symptom categories at two time points over three years, (2) assessed the relationship between variables associated with depression and different depression symptom subscales, and (3) assessed the relationship between symptom subscales and physical disability. In each instance we found significant evidence that items meant to assess vegetative symptoms of depression may be influenced by presence of MS disease symptoms or were not associated with other core elements or central correlates of

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“…To eliminate confounding between MS symptoms and vegetative depressive symptoms, and in order to follow the recommendation of Nyenhuis et al 15 and the precedent of earlier work, 16 only the mood and evaluative subscales were included in the analyses. In order to more thoroughly measure depression, the Beck Depression InventoryFast Screen (BDI-FS) was also used.…”

Section: Methodsmentioning

confidence: 99%

“…The mood and evaluative scores on the CMDI were converted to t scores and averaged using the healthy controls of Nyenhuis and colleagues 15 as the reference point. These t scores were found to be positively skewed even after excluding the univariate outlier, so a negative inverse transformation was used.…”

Section: Data Pre-processingmentioning

confidence: 99%

Attributional Style and Depression in Multiple Sclerosis

Vargas¹,

Arnett²

2013

International Journal of MS Care

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Several etiologic theories have been proposed to explain depression in the general population. Studying these models and modifying them for use in the multiple sclerosis (MS) population may allow us to better understand depression in MS. According to the reformulated learned helplessness (LH) theory, individuals who attribute negative events to internal, stable, and global causes are more vulnerable to depression. This study differentiated attributional style that was or was not related to MS in 52 patients with MS to test the LH theory in this population and to determine possible differences between illness-related and non-illness-related attributions. Patients were administered measures of attributional style, daily stressors, disability, and depressive symptoms. Participants were more likely to list non-MS-related than MS-related causes of negative events on the Attributional Style Questionnaire (ASQ), and more-disabled participants listed significantly more MSrelated causes than did less-disabled individuals. Non-MS-related attributional style correlated with stress and depressive symptoms, but MS-related attributional style did not correlate with disability or depressive symptoms. Stress mediated the effect of non-MS-related attributional style on depressive symptoms. These results suggest that, although attributional style appears to be an important construct in MS, it does not seem to be related directly to depressive symptoms; rather, it is related to more perceived stress, which in turn is related to increased depressive symptoms. Int J MS Care. 2013;15:81-89. Multiple sclerosis (MS) is a chronic, unpredictable, and degenerative disease that causes a variety of symptoms affecting patients' quality of life. The disease course is highly variable, its outcome is hard to predict, and there is no known cure. Depression is extremely common in MS, with an estimated lifetime prevalence of up to 50%.1 This prevalence rate is higher than that found in the general population and in people with most other chronic diseases. 2,3However, the etiology of depression in people with MS remains unclear.Although biological, psychological, and social factors are thought to be involved in depression in MS, individually they show weak or inconsistent relationships. For instance, although some studies show that a combination of the most robust neuropathology measures explains 43% of the variance in depression in MS, 4 other studies have not found strong relationships between neuropathology and depression. Furthermore, MS symptoms such as physical disability, pain, and cognitive dysfunction also demonstrate inconsistent or weak relationships with depression.5 Therefore, interaction among biological, psychological, and social factors seems most likely to predict depressive symptoms in these patients. However, the most conducive combination of factors and the nature of the possible interactions are still unknown. Adapting models of depression used in the general population to MS may improve our understanding of these complex inter...

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Mood disturbance versus other symptoms of depression in multiple sclerosis

Cited by 135 publications

References 20 publications

Depression and multiple sclerosis: Review of a lethal combination

Depression and multiple sclerosis: Review of a lethal combination

Endorsement of self-report neurovegetative items of depression is associated with multiple sclerosis disease symptoms

Attributional Style and Depression in Multiple Sclerosis

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