Mood Disturbances and Regional Cerebral Metabolic Abnormalities inRecently Abstinent Methamphetamine Abusers

London, Edythe D.; Simon, Sara L.; Berman, Steven M.; Mandelkern, M.; Lichtman, Aaron M.; Bramen, Jennifer; Shinn, Ann K.; Miotto, Karen; Learn, Jennifer E.; Dong, Yi; Matochik, John A.; Kurian, Varughese; Newton, Thomas F.; Woods, Roger P.; Rawson, Richard A.; Ling, Walter

doi:10.1001/archpsyc.61.1.73

Cited by 345 publications

(349 citation statements)

References 66 publications

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“…Although METH withdrawal did not induce memory impairments, or depressive-like behaviors in our mouse model, anxiety-like symptoms were observed, including decreased open-arm entries in the EPM and increased defecation during the FST session, which has been previously associated with measures of anxiety (Walf and Frye, 2007) and emotionality (Craft et al, 2010;Marti and Armario, 1993) respectively. These findings are in line with previous studies showing anxiety-like symptoms following withdrawal from METH self-administration (Nawata et al, 2012) and following a steady-dose injection regimen of METH (Kitanaka et al, 2010) in rodents, and anxiety traits in METH-abstinent individuals (London et al, 2004), highlighting the translational value of our model and a direct link between METH abstinence and the emergence of a negative emotional state.…”

Section: Discussionsupporting

confidence: 92%

Methamphetamine abstinence induces changes in μ-opioid receptor, oxytocin and CRF systems: Association with an anxiogenic phenotype

et al. 2016

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Methamphetamine abstinence induces changes in μ-opioid receptor, oxytocin and CRF systems: Association with an anxiogenic phenotype, Neuropharmacology (2016), doi: 10.1016/ j.neuropharm.2016.02.012. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Discussionsupporting

confidence: 92%

Methamphetamine abstinence induces changes in μ-opioid receptor, oxytocin and CRF systems: Association with an anxiogenic phenotype

et al. 2016

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“…In the U.S., for example, treatment admissions for methamphetamine use disorders have steadily increased since 2000. Although acute administration of relatively low oral methamphetamine doses reportedly improves mood and cognitive performance (e.g., Johnson et al 1999Johnson et al , 2000Hart et al 2002), long-term abuse of larger doses, administered via routes other than oral, is associated with mood disturbances (London et al 2004) and cognitive impairments (London et al 2005). These deleterious effects appear to be exacerbated following abrupt discontinuation of methamphetamine use (Peck et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Residual effects of intranasal methamphetamine on sleep, mood, and performance

Perez

Kirkpatrick

Gunderson

et al. 2008

Drug and Alcohol Dependence

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Although intranasal methamphetamine abuse has increased, there are no published data investigating the residual effects of the drug under controlled conditions. Thus, the current study examined the residual effects of single-dose intranasal methamphetamine administration on a broad range of behavioral and physiological measures. Non-treatment seeking methamphetamine abusers (n = 11) completed this two-week, in-patient, within-participant, double-blind study. The study consisted of 4 two-day blocks of sessions; each block was separated by at least 24 hrs. At approximately 1000 hrs, on the first day of each block, participants received one of four intranasal methamphetamine doses (0, 12, 25, 50 mg/70 kg). Lights were turned out at 2300 hrs that evening and sleep measures were assessed. On the morning of the second day of each block, methamphetamine plasma levels, cardiovascular measures, mood, subjective reports of the previous evening's sleep, and psychomotor performance were assessed to determine residual drug effects. The larger methamphetamine doses (25 and 50 mg) markedly disrupted subjective measures of that night's sleep and some indices of next-day mood, but only the largest dose (50 mg) dose decreased objective measures of that night's sleep and increased next-day physiological measures. Methamphetamine did not produce any negative residual effects on early next-day performance. Future studies should assess methamphetamine-related residual effects following repeated doses administered over consecutive days.

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“…[1][2][3][4][5] These deficits appear to reflect regional cerebral dysfunction. When abstinent for 1 week, MA abusers studied with [F-18]fluorodeoxyglucose (FDG) and positron emission tomography (PET) have more severe self-reports of depressive symptoms than control subjects, and these self-reports covary with relative uptake of the radiotracer in anterior cingulate cortex (ACC) and amygdala.…”

Section: Introductionmentioning

confidence: 99%

“…When abstinent for 1 week, MA abusers studied with [F-18]fluorodeoxyglucose (FDG) and positron emission tomography (PET) have more severe self-reports of depressive symptoms than control subjects, and these self-reports covary with relative uptake of the radiotracer in anterior cingulate cortex (ACC) and amygdala. 1 Cingulate and insular dysfunctions may also contribute to impaired vigilance in MA-dependent subjects who recently stopped taking the drug. 6 Anterior cingulate dysfunction has also been observed in subjects who maintained abstinence from MA.…”

Section: Introductionmentioning

confidence: 99%

“…Such effects might have important implications for therapies that involve specific brain circuits, and therefore are the subject of the present report. We hypothesized (1) that abnormalities during the initial week of abstinence from chronic MA abuse (that is, lower relative glucose metabolism in the anterior cingulate gyrus, higher relative glucose metabolism in the striatum) 1 would shift, after an additional month of abstinence, to the pattern previously reported after longer abstinence 8,9 through increases in cortical activity, particularly in the parietal lobes, and (2) that changes in activity would be associated with concurrent changes in cognitive performance, as measured by a vigilance task, and in self-reports of depressive symptoms.…”

Section: Introductionmentioning

confidence: 99%

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Changes in cerebral glucose metabolism during early abstinence from chronic methamphetamine abuse

et al. 2007

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Changes in brain function during the initial weeks of abstinence from chronic methamphetamine abuse may substantially affect clinical outcome, but are not well understood. We used positron emission tomography with [F-18]fluorodeoxyglucose (FDG) to quantify regional cerebral glucose metabolism, an index of brain function, during performance of a vigilance task. A total of 10 methamphetamine-dependent subjects were tested after 5-9 days of abstinence, and after 4 additional weeks of supervised abstinence. A total of 12 healthy control subjects were tested at corresponding times. Global glucose metabolism increased between tests (P = 0.01), more in methamphetamine-dependent (10.9%, P = 0.02) than control subjects (1.9%, NS). Glucose metabolism did not change in subcortical regions of methamphetaminedependent subjects, but increased in neocortex, with maximal increase ( > 20%) in parietal regions. Changes in reaction time and self-reports of negative affect varied more in methamphetamine-dependent than in control subjects, and correlated both with the increase in parietal glucose metabolism, and decrease in relative activity (after scaling to the global mean) in some regions. A robust relationship between change in self-reports of depressive symptoms and relative activity in the ventral striatum may have great relevance to treatment success because of the role of this region in drug abuse-related behaviors. Shifts in corticalsubcortical metabolic balance either reflect new processes that occur during early abstinence, or the unmasking of effects of chronic methamphetamine abuse that are obscured by suppression of cortical glucose metabolism that continues for at least 5-9 days after cessation of methamphetamine self-administration.

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Mood Disturbances and Regional Cerebral Metabolic Abnormalities inRecently Abstinent Methamphetamine Abusers

Cited by 345 publications

References 66 publications

Methamphetamine abstinence induces changes in μ-opioid receptor, oxytocin and CRF systems: Association with an anxiogenic phenotype

Methamphetamine abstinence induces changes in μ-opioid receptor, oxytocin and CRF systems: Association with an anxiogenic phenotype

Residual effects of intranasal methamphetamine on sleep, mood, and performance

Changes in cerebral glucose metabolism during early abstinence from chronic methamphetamine abuse

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