Mood symptoms and suicidality across the autism spectrum

Dell’Osso, Liliana; Carpita, Barbara; Muti, Dario; Morelli, Valentina; Salarpi, Gianluca; Salerni, Antonio; Jole, Scotto; Massimetti, Gabriele; Gesi, Camilla; Ballerio, Martina; Signorelli, Maria; Luciano, Mario; Politi, Pierluigi; Aguglia, Eugenio; Carmassi, Claudia; Maj, Mario

doi:10.1016/j.comppsych.2019.03.004

Cited by 77 publications

(93 citation statements)

References 45 publications

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“…These results concerning preference for routine and attention-switching difficulties are similar to those of a previous study by Dell'Osso et al 15) . They reported that the strongest predictors of suicidality score were restricted interests and the rumination domain score of autistic traits.…”

Section: Discussionsupporting

confidence: 92%

“…Some related concepts have been found to be associated with suicidality or general psychiatric disorder. For example, Dell'Osso et al 15) reported that restricted interests and rumination domain scores on the Adult Autism Subthreshold Spectrum (AdAS) were associated with suicidality in patients with full-blown ASD and subjects with autistic traits, as well as in a healthy control group. Carpita et al 16) found that AdAS nonverbal communication domain scores were a statistically predictive variable for the presence of psychiatric disorders among 120 parents of ASD children.…”

Section: Introductionmentioning

confidence: 99%

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Which autistic traits are related to depressive symptoms in Japanese workers?

Miyaki

Tsutsumi

2020

INDUSTRIAL HEALTH

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Individuals with autism spectrum disorders are at a high risk of experiencing depressive symptoms. However, the relationship between autistic traits and depressive symptoms is unclear. This study aimed to identify which autistic traits are related to depressive symptoms in Japanese workers. The study participants included 2,049 workers from all areas of Japan. Autistic traits and depressive symptoms were measured using an abridged Japanese version of the Autism-Spectrum Quotient (AQ-Short) and the Japanese version of the K6 scale, respectively. The AQ-Short comprises five autistic trait subcomponents that assess fascination for numbers/patterns, difficulties with imagination, preference for routine, difficulties with social skills, and attention-switching difficulties. Linear regression analyses were performed to estimate the association between total and subcomponent autistic trait scores and depressive symptoms. Participants with higher total autistic trait scores were significantly more likely to have depressive symptoms (P < 0.001). When scores on the five autistic trait subcomponents were entered simultaneously into the model, participants with higher scores on all subcomponents other than 'difficulties with imagination' were significantly more likely to report depressive symptoms. Total autistic traits and autistic 3 trait subcomponents could be used for early detection of the risk of depressive symptoms.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Which autistic traits are related to depressive symptoms in Japanese workers?

Miyaki

Tsutsumi

2020

INDUSTRIAL HEALTH

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“…62 This clue is particularly interesting considering the increasing body of studies suggesting a possible role of AT as a promoting factor for different psychiatric conditions. [63][64][65][66][67][68][69][70] As Dell'Osso et al 63,71 pointed out, ruminative thinking, often associated with subthreshold AT, could be considered as a common transnosological underpinning of several different psychiatric disorders that may affect prognosis and increase the risk of chronic course and suicidality. According to this paradigm, our study may contribute in supporting the dimensional association between depressive ruminations, SAD and OCD subthreshold symptoms, considering the high correlations, found also in MDD patients and in HC, between doubt and interpersonal sensitivity.…”

Section: Cns Spectrumsmentioning

confidence: 99%

Overlapping features between social anxiety and obsessive-compulsive spectrum in a clinical sample and in healthy controls: toward an integrative model

et al. 2019

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Background.While the literature frequently highlighted an association between social anxiety disorder (SAD) and obsessive-compulsive disorder (OCD), few studies investigated the overlapping features of these conditions. The presented work evaluated the relationship between SAD and OCD spectrum in a clinical population and in healthy controls (HC).Methods.Fifty-six patients with OCD, 51 with SAD, 43 with major depressive disorder (MDD), and 59 HC (N = 209) were assessed using the Mini International Neuropsychiatric Interview, the Social Phobia Spectrum (SCI-SHY), and the Obsessive-Compulsive Spectrum (SCI-OBS).Results.SAD patients scored significantly higher than other groups on all SCI-SHY domains and total score; OCD patients scored significantly higher than HC. MDD patients scored significantly higher than HC on the SCI-SHY total, Behavioral inhibition, and Interpersonal sensitivity domains. OCD patients scored significantly higher than other groups on all SCI-OBS domains except Doubt, for which OCD and SAD scored equally high. SAD patients scored significantly higher than HC on the SCI-OBS total, Childhood/adolescence, Doubt, and Hypercontrol domains. MDD patients scored significantly higher than HC on the Hypercontrol domain. SCI-OBS and SCI-SHY were widely correlated among groups, although lower correlations were found among OCD patients. Stronger correlations were observed between SCI-SHY Interpersonal sensitivity and SCI-OBS Doubt, Obsessive-compulsive themes, and Hypercontrol; between SCI-SHY Specific anxieties/phobic features and SCI-OBS Obsessive-compulsive themes; and between SCI-SHY Behavioral inhibition and SCI-OBS Doubt, with slightly different patterns among groups.Conclusion.OCD and SAD spectrums widely overlap in clinical samples and in the general population. Interpersonal sensitivity and obsessive doubts might represent a common cognitive core for these conditions.

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“…While both BD and HF-ASD represent independent risk factors for suicidal ideation and behavior, their association in terms of increased suicidal risk is strongly under-explored in clinical samples. Dell’Osso and colleagues [ 33 ] investigated the prevalence of suicidal ideation in 34 adult individuals with ASD without intellectual disability, 68 with subthreshold ASD (“autistic traits”), and 160 healthy controls. Individuals with ASD reported significantly higher scores than the other two groups in mood disorders and depression, while the subthreshold autistic individuals presented higher scores than the heathy control group.…”

Section: Introductionmentioning

confidence: 99%

Suicidal Ideation and Suicidal Attempts in Referred Adolescents with High Functioning Autism Spectrum Disorder and Comorbid Bipolar Disorder: A Pilot Study

et al. 2020

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Suicidal ideation and attempts in adolescents are closely associated to bipolar disorders (BD). Growing evidence also suggests that high functioning autism spectrum disorders (HF-ASD) are at increased risk for suicidal ideation and behaviors. Although BD and HF-ASD are frequently comorbid, no studies explored suicidality in these individuals. This exploratory study addressed this issue in a clinical group of inpatient adolescents referred to a psychiatric emergency unit. Seventeen adolescents with BD and HF-ASD and severe suicidal ideation or attempts (BD-ASD-S), were compared to 17 adolescents with BD and HF-ASD without suicidal ideation or attempts (BD-ASD-noS), and to 18 adolescents with BD and suicidal ideation or attempts without ASD (BD-noASD-S), using a structured assessment methodology. Individuals with BD-ASD-S had a higher intelligence quotient, more severe clinical impairment, more lethality in suicide attempts, more internalizing symptoms, less impulsiveness, and lower social competence. Severity of ASD traits in individuals and parents did not correlate with suicidal risk. Some dimensions of resilience were protective in terms of repulsion by life and attraction to death. Main limitations are the small sample size, the lack of a control group of typically developing adolescents. However, a better understanding of the specificities of bipolar HF-ASD individuals with suicidality may improve prevention and treatment strategies.

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Mood symptoms and suicidality across the autism spectrum

Cited by 77 publications

References 45 publications

Which autistic traits are related to depressive symptoms in Japanese workers?

Which autistic traits are related to depressive symptoms in Japanese workers?

Overlapping features between social anxiety and obsessive-compulsive spectrum in a clinical sample and in healthy controls: toward an integrative model

Suicidal Ideation and Suicidal Attempts in Referred Adolescents with High Functioning Autism Spectrum Disorder and Comorbid Bipolar Disorder: A Pilot Study

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