Morbid Obesity and Inflammation: A Prospective Study After Adjustable Gastric Banding Surgery

Ramalho, Renata; Guimarães, Cristina; Gil, Cidália; Neves, Celestino; Guimarães, João Tiago; Delgado, Luís

doi:10.1007/s11695-009-9848-0

Cited by 18 publications

(13 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed WAT, but not liver Hp expression, is induced in HFD mice (46), thus establishing the tissue specificity of obesity mediated induction of Hp. Importantly, such increase is clearly associated with an enhanced inflammatory status, as demonstrated by the positive relationship found between circulating levels of Hp and those of other inflammatory markers typically induced in obesity, like CRP and TNF␣ (29) (47,76). The causal link with the latter has been detailed above.…”

Section: Circulating Hp As a Marker Of Adipositymentioning

confidence: 83%

“…Intriguingly some of the alterations indicate diminished apoptosis in the obese Hp deficient mouse liver, but whether these molecular features are reflected in a less apoptotic phenotype or if they are upstream or downstream of the protection against hepatosteatosis was not investigated. Further understanding of of Hp role in hepatosteatosis will shed light on the controversial subject of fatty liver in relation to apoptosis (76,110,111,112).…”

Section: Future Directionsmentioning

confidence: 99%

See 1 more Smart Citation

The Multifaceted Haptoglobin in the Context of Adipose Tissue and Metabolism

et al. 2016

View full text Add to dashboard Cite

Obesity is a low chronic inflammatory state because several inflammatory factors are increased in obese subjects, this having important implications for the onset of obesity-associated complications. The source of most of these inflammatory molecules is white adipose tissue (WAT), which upon excessive weight gain, becomes infiltrated with macrophages and lymphocytes and undergoes important changes in its gene expression. Haptoglobin (Hp), a typical marker of inflammation in clinical practice, main carrier of free hemoglobin, and long known to be part of the hepatic acute phase response, perfectly sits in the intersection between obesity and inflammation: it is expressed by adipocytes and its abundance in WAT and in plasma positively relates to the degree of adiposity. In the present review, we will analyze causes and consequences of Hp expression and regulation in WAT and how these relate to the obesity/inflammation paradigm and comorbidities.

show abstract

Section: Circulating Hp As a Marker Of Adipositymentioning

confidence: 83%

Section: Future Directionsmentioning

confidence: 99%

The Multifaceted Haptoglobin in the Context of Adipose Tissue and Metabolism

et al. 2016

View full text Add to dashboard Cite

show abstract

“…However, Anty and colleagues (82) reported that six months after bariatric surgery (94% gastric bypass), in a cohort of pre-menopausal women, TSAT was significantly higher (18% vs. 25%; p<0.0001). Also, several other studies have reported no significant change in iron status following gastric bypass or gastric banding surgery (83–85) While another study reported a significant decrease in sTfR concentrations at 18 months post-surgery (baseline: 1.40 vs. follow-up 1.27 mg/l; p <0.05) suggesting improvement in iron status (86). …”

Section: Obesity: Iron Status Absorption Hepcidin Ex Pression and mentioning

confidence: 99%

Rethinking Iron Regulation and Assessment in Iron Deficiency, Anemia of Chronic Disease, and Obesity: Introducing Hepcidin

Tussing‐Humphreys

Pustacioglu

Nemeth

2012

Journal of the Academy of Nutrition and Dietetics

128

115

View full text Add to dashboard Cite

Adequate iron availability is essential to human development and overall health. Iron is a key component of oxygen-carrying proteins, has a pivotal role in cellular metabolism, and is essential to cell growth and differentiation. Inadequate dietary iron intake, chronic and acute inflammatory conditions, and obesity are each associated with alterations in iron homeostasis. Tight regulation of iron is necessary because iron is highly toxic and human beings can only excrete small amounts through sweat, skin and enterocyte sloughing, and fecal and menstrual blood loss. Hepcidin, a small peptide hormone produced mainly by the liver, acts as the key regulator of systemic iron homeostasis. Hepcidin controls movement of iron into plasma by regulating the activity of the sole known iron exporter ferroportin-1. Downregulation of the ferroportin-1 exporter results in sequestration of iron within intestinal enterocytes, hepatocytes, and iron-storing macrophages reducing iron bioavailability. Hepcidin expression is increased by higher body iron levels and inflammation and decreased by anemia and hypoxia. Importantly, existing data illustrate that hepcidin may play a significant role in the development of several iron-related disorders, including the anemia of chronic disease and the iron dysregulation observed in obesity. Therefore, the purpose of this article is to discuss iron regulation, with specific emphasis on systemic regulation by hepcidin, and examine the role of hepcidin within several disease states, including iron deficiency, anemia of chronic disease, and obesity. The relationship between obesity and iron depletion and the clinical assessment of iron status will also be reviewed.

show abstract

“…As mentioned above, the restrictive bariatric interventions AGB and sleeve gastrectomy improved functional iron status as indicated by a decrease in hepcidin and an increase in transferrin saturation [44]. Nonetheless, improvement in functional iron status was reported along with weight reduction after restrictive procedures, whereas after malabsorptive procedures, worsening of ID or at least persistence is frequently observed [60,61]. …”

Section: Bariatric Surgery and Iron Deficiencymentioning

confidence: 99%

Obesity as an Emerging Risk Factor for Iron Deficiency

2014

View full text Add to dashboard Cite

Iron homeostasis is affected by obesity and obesity-related insulin resistance in a many-facetted fashion. On one hand, iron deficiency and anemia are frequent findings in subjects with progressed stages of obesity. This phenomenon has been well studied in obese adolescents, women and subjects undergoing bariatric surgery. On the other hand, hyperferritinemia with normal or mildly elevated transferrin saturation is observed in approximately one-third of patients with metabolic syndrome (MetS) or nonalcoholic fatty liver disease (NAFLD). This constellation has been named the “dysmetabolic iron overload syndrome (DIOS)”. Both elevated body iron stores and iron deficiency are detrimental to health and to the course of obesity-related conditions. Iron deficiency and anemia may impair mitochondrial and cellular energy homeostasis and further increase inactivity and fatigue of obese subjects. Obesity-associated inflammation is tightly linked to iron deficiency and involves impaired duodenal iron absorption associated with low expression of duodenal ferroportin (FPN) along with elevated hepcidin concentrations. This review summarizes the current understanding of the dysregulation of iron homeostasis in obesity.

show abstract

Morbid Obesity and Inflammation: A Prospective Study After Adjustable Gastric Banding Surgery

Cited by 18 publications

References 39 publications

The Multifaceted Haptoglobin in the Context of Adipose Tissue and Metabolism

The Multifaceted Haptoglobin in the Context of Adipose Tissue and Metabolism

Rethinking Iron Regulation and Assessment in Iron Deficiency, Anemia of Chronic Disease, and Obesity: Introducing Hepcidin

Obesity as an Emerging Risk Factor for Iron Deficiency

Contact Info

Product

Resources

About