Morbid obesity and pregnancy outcomes after single blastocyst transfer: a retrospective, North American study

Abstract

Morbid obesity is a strong and independent predictor of poor pregnancy outcomes in patients undergoing top-quality SBT.

Arabian Peninsula ethnicity is associated with lower ovarian reserve and ovarian response in women undergoing fresh ICSI cycles

“…However, recent studies have shown no association between vitamin D levels and ovarian reserve, ovarian response, or pregnancy rates [34][35][36]. Finally, although BMI was controlled for in our study, it is possible for obesity to be an independent mediator of lower ovarian reserve, ovarian response, and pregnancy rates in ICSI-ET cycles [37][38][39].…”

The influence of body mass index on pregnancy outcome following single-embryo transfer

“…Studies on single-embryo transfers showed that obesity was negatively associated with the occurrence of live birth [24]. A retrospective study found that morbid obesity significantly increased miscarriage rates and reduced live birth rates [25]. However, in contrast to our research, their study included only blastocyst transfer and fresh and frozen embryos.…”

Association between maternal prepregnancy body mass index and pregnancy outcomes following assisted reproductive technology: A systematic review and dose–response meta‐analysis

“…In the final analysis, 105 eligible studies (19 prospective and 86 retrospective cohort studies) were included, involving more than 271,632 pregnant women (Figure 1). 14,15,28–130 The main characteristics of included studies were summarized in Table S1. In total, 100 studies reported the association between maternal BMI and CPR among pregnant women undergoing ART, among which 53 reported MR and 51 reported LBR (Table S1).…”

“…In total, 100 studies reported the association between maternal prepregnancy body weight and CPR after ART 14,15,28–55,58–80,82–117,119–122,124–130 . At per‐woman level, 54 studies, involving 109,688 pregnant women, showed an inverted J‐shaped relationship between maternal BMI and CPR ( P n < 0.01) 14,28–31,34–36,40,41,44,46,47,49,53,58,60,61,64–68,75,76,78,82,85,86,88–95,97,99,103–106,109,112–114,119,121,124,126–128,130 . Compared with the reference BMI value (21.75 kg/m 2 ), BMI > 22.5 kg/m 2 was associated with lower CPR (Figure 2a and Table 1).…”

“…Fifty‐one studies, involving 283,386 cycles, were included in the per‐cycle level analysis 14,28,30,33–37,39,41–43,45,48,50,52–54,58,61,64,66–69,75,77,78,80,82,83,85,87,89,91,92,94–99,103–106,112,114,121,126,130 . We presented the results for both linear and nonlinear dose–response ( P n = 0.08).…”