Morbid obesity impacts mortality among inpatients with type a aortic dissection: an analysis of the national inpatient sample

Abstract

Background Stanford type A aortic dissection (T(A)AD) is one of the most dangerous cardiovascular diseases and morbid obesity is associated with the prognosis of many cardiovascular diseases. The aim of this study is to investigate the impact of morbid obesity on in-hospital mortality, total hospital costs and discover the prevalence of morbid obesity among inpatients with T(A)AD. Methods Patients with a primary diagnosis of T(A)AD were identified from the National Inpatient Sample database (NIS) from 2008 to 2017. These patients were categorized into non-obesity, obesity and morbid obesity. Multivariable regression models were utilized to assess the association between obesity/morbid obesity and in-hospital mortality, total cost and other clinical factors. The temporal trend in prevalence of obesity/morbid obesity in T(A)ADs and the trend of in-hospital mortality among different weight categories were also explored. Results From the NIS database 8489 T(A)AD inpatients were identified, of which 7230 (85.2%) patients were non-obese, 822 (9.7%) were obese and 437 (5.1%) were morbid obese. Morbid obesity was associated with increased risk of in-hospital mortality (odds ratio [OR] 1.39; 95% confidence interval [CI] 1.03–1.86), 8% higher total cost compared with the non-obese patients. From 2008 to 2017, the rate of obesity and morbid obesity in patients with T(A)AD have significantly increased from 7.36 to 11.33% (P < 0.001) and from 1.95 to 7.37% (P < 0.001). Factors associated with morbid obesity in T(A)ADs included age, female, elective admission, hospital region, dyslipidemia, smoking, rheumatoid arthritis/collagen vascular diseases, chronic pulmonary disease, diabetes and hypertension. Conclusions Morbid obesity are connected with worse clinical outcomes and more health resource utilization in T(A)AD patients. Appropriate medical resource orientation and weight management education for T(A)AD patients may be necessary.

Investigation of the Association between Bilateral Selective Anterograde Cerebral Perfusion and Postoperative Ischemic Stroke in Obese Patients with Emergency Surgery for Acute Type A Aortic Dissection

“…The incidence of obesity is increasing in all industrialized countries and frequen comorbid conditions such as diabetes mellitus, hypertension, hyperlipidemia, and obe sity-induced systemic inflammation pose a challenge to care during cardiac surgery, es pecially those with cardiopulmonary bypass [11]. Patients with obesity are more predis posed to developing ATAAD [12]. Moreover, obese patients with emergency surgery fo ATAAD had higher operative mortality and an increased risk of low cardiac output syn drome and pulmonary complications [12,13].…”

“…Patients with obesity are more predis posed to developing ATAAD [12]. Moreover, obese patients with emergency surgery fo ATAAD had higher operative mortality and an increased risk of low cardiac output syn drome and pulmonary complications [12,13].…”

Reduction of oxidative stress response and protection of liver and renal cell functions by reduced glutathione in lower limb arterial ischemia–reperfusion in New Zealand white rabbits with high triglyceride levels

“…Although the BMI of men is higher than that of women, the body fat percentage of women is higher than that of men [ 10 ]. Factors such as female gender, dyslipidaemia, smoking, diabetes mellitus, and hypertension have been associated with the postoperative increases in interleukin—1β(IL-1β), tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), C-reactive protein, malondialdehyde (MDA), and white blood cell levels after aortic dissection surgery, rendering them risk factors for postoperative mortality after surgery for type A aortic dissection [ 11 ].…”