“…Ultra-endurance running is not a uniform sport but can be defined as a broad category with different types of running activities, such as running events by distance (e.g., any distance in excess of the standard marathon distance of 42.195 km), time (timed-UER, e.g., any events over 6 h) and multi day/multistage events (distance or timed events over several days or stages) (Scheer et al, 2020a). UER events can be held on various surfaces (e.g., track, on-road, off-road) (Scheer et al, 2020a) and in extreme challenging environments, putting additional strain on the human body (e.g., extreme cold, altitude, mountain, desert, heat and jungle) (Knoth et al, 2012;da Fonseca-Engelhardt et al, 2013;Gill et al, 2015;Scheer and Murray, 2015;Dawadi et al, 2020;Suter et al, 2020). The most popular race distances are those of 50 km, 100 km, and 100 miles (Cejka et al, 2014;Scheer, 2019;Knechtle et al, 2020), but can also include distances in excess of 1000 km (Fallon, 1996;Schütz et al, 2012;Scheer et al, 2020a), whereas time-limited events often include 6, 12, or 24 h events, with some lasting several days (Hutson, 1984;Bishop and Fallon, 1999;Scheer et al, 2020a).…”