2014
DOI: 10.1245/s10434-014-3969-y
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Morbidity Among Long-Term Survivors After Pancreatoduodenectomy for Pancreatic Adenocarcinoma

Abstract: Long-term survivors among patients who undergo pancreatoduodenectomy for pancreatic adenocarcinoma can experience significant late sequelae, which often manifest more than 3 years after surgery. As such, continued follow-up evaluation and counseling are warranted.

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Cited by 13 publications
(7 citation statements)
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“…The incidence of SMNs is generally 2%–10% and the prevalence is 6.6%–9%, accounting for about 16% of overall cancer incidence 2,3,5. So far, very few publications have reported an analysis of second primary extrapancreatic malignancies following PDAC, probably because of the poor prognosis of these patients 2,69. A large population-based study calculated the incidence of SMNs diagnosed after the diagnosis of PDAC to be lower when compared to other cancers (around 1.3%) 8,14.…”
Section: Discussionmentioning
confidence: 99%
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“…The incidence of SMNs is generally 2%–10% and the prevalence is 6.6%–9%, accounting for about 16% of overall cancer incidence 2,3,5. So far, very few publications have reported an analysis of second primary extrapancreatic malignancies following PDAC, probably because of the poor prognosis of these patients 2,69. A large population-based study calculated the incidence of SMNs diagnosed after the diagnosis of PDAC to be lower when compared to other cancers (around 1.3%) 8,14.…”
Section: Discussionmentioning
confidence: 99%
“…Because of the unfavorable prognosis, very few long-term PDAC survivors will develop SMN 2,3. Consequently, there are very few reports about SMNs in PDAC survivors and their prognosis, and there is no information on the genetic background of these patients 29…”
Section: Introductionmentioning
confidence: 99%
“…That QOL can be favorable following pancreatectomy may seem implausible to healthcare providers accustomed to significant rates of short‐term morbidity following surgery. In addition to perioperative adverse events, patients undergoing pancreatic surgery are at increased risk for late complications such as biliary stricture, portal vein thrombosis, endocrine and exocrine insufficiency, post‐splenectomy syndrome, and second malignancies . Nevertheless, the evidence seems to suggest that any short‐term decrements in patient‐reported outcomes due to the magnitude of surgery and its related complications do not necessarily extend to long‐term QOL impairment.…”
Section: Discussionmentioning
confidence: 99%
“…Of all patients undergoing PD, nearly one-fifth may late reinterventions with percutaneous, endoscopic or surgical procedures [ 2 ]. In contrast to early complications, late complications tend to require more invasive interventions [ 2 , 9 , 10 ]. Large bowel volvulus has not yet been described as potential long-term complication.…”
Section: Discussionmentioning
confidence: 99%