Morbidity and mortality in sarcoidosis

Gerke, Alicia K.

doi:10.1097/mcp.0000000000000080

Cited by 92 publications

(57 citation statements)

References 68 publications

(86 reference statements)

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“…However, race was not associated with time to diagnosis in a study of U.S. patients with sarcoidosis (24). Alternatively, the different age patterns may be explained by race-related differences in clinical presentation (3,5) and possibly etiology of sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

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Epidemiology of Sarcoidosis in a Prospective Cohort Study of U.S. Women

et al. 2016

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Rationale: Sarcoidosis is a systemic granulomatous and inflammatory disorder that most often involves the lungs but also affects many other organs. Data on sarcoidosis from large epidemiological studies remain scarce.Objectives: To evaluate the baseline prevalence and 22-year incidence of sarcoidosis and their associations with demographic and geographic characteristics in a large cohort of U.S. women. Methods:The Nurses' Health Study II is a prospective cohort study of U.S. female nurses enrolled in 1989 (aged 25-44 yr, n = 116,430). Data on major illnesses were collected through biennial questionnaires . Cases were identified by the nurses' self-report of physician-diagnosed sarcoidosis. Associations of demographic and geographic characteristics with sarcoidosis were evaluated by logistic regression and Cox models. Measurements and Main Results:A total of 377 sarcoidosis cases were identified. The baseline prevalence was 100/100,000 women. The average annual incidence rate was 11/100,000 during 2,275,028 person-years of follow up. Incidence rate increased with age (P = 0.003), from 9 to 15/100,000 in women aged less than 35 to 55 or more years, respectively. Black women had a higher prevalence (odds ratio, 5.24; 95% confidence interval, 2.87-9.55) and incidence (hazard ratio, 3.80; 95% confidence interval, 2.31-6.24) than white women. Across U.S. regions, more than twofold differences were observed in sarcoidosis prevalence and incidence, with consistently higher rates in the Northeast. Conclusions:We provide recent national data on the epidemiology of sarcoidosis among U.S. women. Important differences in prevalence and incidence were observed across U.S. regions. Large epidemiological studies are needed to better understand the causes of the observed demographic and geographic differences in sarcoidosis.

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Section: Discussionmentioning

confidence: 99%

“…Skin, eye, cardiac, or nervous system involvements are common (2)(3)(4). The clinical course ranges from asymptomatic forms with spontaneous remission to chronic disease leading to significant organ impairment and death in 5% of patients (2,5). The disease can occur at any age but is believed to be more common in young to middle-aged adults (1,2,4,6).…”

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confidence: 99%

Epidemiology of Sarcoidosis in a Prospective Cohort Study of U.S. Women

et al. 2016

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“…Although sarcoidosis resolves spontaneously in many cases, about one-third of patients experience chronic disease associated with significant morbidity [2]. …”

Section: To the Editormentioning

confidence: 99%

Prospective study of body mass index and risk of sarcoidosis in US women

et al. 2017

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“…Sarkoidose Die Sarkoidose geht zu über 90% mit einer Beteiligung der Lungen einher [13], die Datenlage zur Häufigkeit einer renalen Beteiligung ist heterogen. Die subklinische Häufigkeit ist mit bis zu 48% [3] wahrscheinlich deutlich höher als in der Literatur oftmals berichtet (0,5-2%, [53]).…”

Section: Rheumatologische Erkrankungen Als Ursache Einer Interstitielunclassified

Interstitielle Nephritis bei rheumatischen Erkrankungen

Korsten

Müller

2015

Z Rheumatol

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Interstitial nephritis is responsible for about 12 % of end-stage renal disease in Germany. It comprises an etiologically heterogenous group of inflammatory renal disorders which primarily affect the renal interstitium and tubuli. Drugs, predominantly antibiotics, nonsteroidal anti-inflammatory drugs and proton pump inhibitors are causative in the majority of cases. Rheumatic diseases frequently affect the kidneys, either the glomeruli or the interstitial tissues. Inflammatory interstitial processes can be accompanied by complex functional tubular disorders. This review gives an overview about clinical and laboratory findings of interstitial nephritis in the context of rheumatic diseases. Sarcoidosis, tubulointerstitial nephritis and uveitis (TINU) syndrome, primary Sjogren's syndrome, and IgG4-related disease often show an interstitial nephritis when the kidneys are affected. Other diseases, such as systemic lupus erythematosus, systemic sclerosis, drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, and granulomatosis with polyangiitis are more rarely associated with predominant interstitial nephritis. Glucocorticoids are the mainstay of therapy for most cases; in refractory cases or when side effects occur, second-line immunosuppressants such as mycophenolate mofetil, azathioprine and others, rarely biologics, can be used.

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Morbidity and mortality in sarcoidosis

Cited by 92 publications

References 68 publications

Epidemiology of Sarcoidosis in a Prospective Cohort Study of U.S. Women

Epidemiology of Sarcoidosis in a Prospective Cohort Study of U.S. Women

Prospective study of body mass index and risk of sarcoidosis in US women

Interstitielle Nephritis bei rheumatischen Erkrankungen

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