Morbidity and mortality of coagulase-negative staphylococcal sepsis in very-low-birth-weight infants

Cantey, Joseph B.; Anderson, Kelsey R.; Kalagiri, Ram R.; Mallett, Lea

doi:10.1007/s12519-018-0145-7

Cited by 30 publications

(25 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[11,12,45,47,50] As far as the type of bacteria resulted in the sepsis, 4 studies identified the specific bacteria. Three of them [13,23,30] investigated the relationship of coagulase-negative Staphylococcus (CoNS) sepsis and ROP. However, there was no study to identify the different impact factors on ROP between bacterial and fungal sepsis.…”

Section: Discussionmentioning

confidence: 99%

Cumulative evidence for association of sepsis and retinopathy of prematurity

et al. 2019

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Cumulative evidence for association of sepsis and retinopathy of prematurity

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The increase of CoNS impact on the clinical field was emphasized by the extensive medical progress, where the use of implantable medical devices and the increasing number of vulnerable patients have allowed CoNS to cause significant infections in humans [10]. More importantly, these factors have elevated the number of morbid, chronically ill and immunocompromised patients, as well as the mortality rates related to CoNS [11,12]. Moreover, as CoNS are known to colonize both farm and domestic animals, they may as well establish infections upon opportunity, although to a lesser extent.…”

Section: Introductionmentioning

confidence: 99%

Virulence Factors in Coagulase-Negative Staphylococci

et al. 2021

View full text Add to dashboard Cite

Coagulase-negative staphylococci (CoNS) have emerged as major pathogens in healthcare-associated facilities, being S. epidermidis, S. haemolyticus and, more recently, S. lugdunensis, the most clinically relevant species. Despite being less virulent than the well-studied pathogen S. aureus, the number of CoNS strains sequenced is constantly increasing and, with that, the number of virulence factors identified in those strains. In this regard, biofilm formation is considered the most important. Besides virulence factors, the presence of several antibiotic-resistance genes identified in CoNS is worrisome and makes treatment very challenging. In this review, we analyzed the different aspects involved in CoNS virulence and their impact on health and food.

show abstract

“…In this retrospective hospital-based cohort study, we found the overall incidence of LOS in VLBW infants over 7 years was 24.08% and culture-proven LOS was 19.58%, which was similar to the reports from South America, 7 Korea, 1 Brazil, 13 lower than that of Saudi Arabia 10 or Guangzhou of China 9 but higher than that of Hongkong 5 or Beijing of China, 8 Texas of USA. 14 This may be due to disparities in measures of infection control, years of investigation, the definition of LOS, and study criteria for inclusion and exclusion. In general, the incidence of LOS in VLBW preterm infants was higher than that in overall neonates.…”

Section: Discussionmentioning

confidence: 99%

Late-onset sepsis in very low birth weight preterm infants: 7 years' experience at a tertiary hospital in China

Peng

Wang

et al. 2021

Pediatrics & Neonatology

View full text Add to dashboard Cite

Objective: Studies about the epidemiology and risk factors of late onset of sepsis (LOS) in preterm very low birth weight (PVLBW) infants of developing countries are limited and variable. The objective of this study was to explore the epidemiology, risk factors and pathogens of LOS in VLBW infants in a Chinese tertiary hospital. Methods: Data concerning demographies, pathogens, risk factors and outcomes of LOS were collected in a cohort of 710 VLBW infants discharged from January 2012 to December 2018. Chi-square, t-test and multivariable logistic regression analysis were used to identify risk factors. Results: The overall incidence of LOS was 24.08% and blood culture-proven sepsis was 19.58%. Gram-negative bacteria accounted for 57.93%, and 32.41% of the isolates were Klebsiella pneumoniae. LOS led to a longer hospital stay, higher hospitalization cost and higher mortality compared to infants without LOS. Mortality in Gram-negative or fungi LOS was higher than in Gram-positive LOS. The factor of PVLBW infants with registered permanent residence (PR) was associated with 80% lower likelihood of LOS compared to those without registered PR (P Z 0.000, 95% CI 0.096e0.420). Infants with thrombocytopenia had 2.5 times LOS of control

show abstract

Morbidity and mortality of coagulase-negative staphylococcal sepsis in very-low-birth-weight infants

Abstract: CoNS sepsis was not associated with mortality or morbidities other than length of stay. These findings support vancomycin-reduction strategies in the NICU.

Cited by 30 publications

References 28 publications

Cumulative evidence for association of sepsis and retinopathy of prematurity

Cumulative evidence for association of sepsis and retinopathy of prematurity

Virulence Factors in Coagulase-Negative Staphylococci

Late-onset sepsis in very low birth weight preterm infants: 7 years' experience at a tertiary hospital in China

Contact Info

Product

Resources

About