Morbidity and Mortality of the Short-Bowel Syndrome

Abstract

From 1976 to 1998 we have treated 17 neonates with short-bowel syndrome. Those 8 patients who had an intact ileocecal valve as well as the total colon preserved did significantly better than the 9 children without ileocecal valve and > 50% missing colon. In addition to the length of the intestinal remnants, motility had a major impact on the incidence of complications and final outcome. Four patients died (23.5%). All of them had an intestinal length of less than 30 cm, severe dysmotility, no ileocecal valve and an incomplete colon. The average duration of hospitalization of the children weaned from parenteral nutrition (n = 11) was 8.5 months. The majority of them still need supplementation of vitamins and/or trace elements. Two children suffer from recurrent d-lactic acidemia. Six children have a significant psychomotor developmental delay with three suffering from congenital cerebral abnormalities.

Long-term parenteral nutritional support and intestinal adaptation in children with short bowel syndrome: A 25-year experience

“…The major impact of an intact ICV is appreciated if the SBL is < 15 cm. SBL has been consistently an important factor to predict intestinal adaptation, 4,8,[13][14][15] whereas the presence of an intact ICV has been a predictor 4,8,15,16 or not a predictor 5,13,14 of who will be able to discontinue PN. What makes the evaluation of the impact of ICV resection so difficult is that it is usually done along with colonic and terminal ileum resections.…”

Intestinal involvement during 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced chronic liver injury in a mouse model

“…Intestinal failure-associated liver disease is one of the more common clinical settings in which these 2 entities coexist [9]. Progressive hyperbilirubinemia and end-stage liver failure seem to be the most serious complications of short bowel syndrome, representing the final cause of death in most fatal cases [10].…”

Extensive small bowel resection in dogs and cats: 20 cases (1998–2004)

“…Therefore, we could not determine whether removal of a portion of the ileum or removal of the ileocolic valve would be associated with a poorer outcome, although this has been demonstrated in previous studies. [15][16][17][18][19] Treatment of SBS in dogs has been aimed at providing adequate nutritional support and controlling diarrhea and other manifestations of SBS until intestinal adaptation can occur. Intestinal adaptation begins within days after surgery 3,20 and results in restoration of the absorptive capacity of the intestine through compensatory growth of the remaining intestinal segment and an increase in mucosal surface area.…”