Morbidity in children with frequently relapsing nephrosis: 10-year follow-up of a randomized controlled trial

Abstract

This 10-year follow-up study shows that most children with FRNS experience relapses after 2 years of cyclosporine treatment, in adolescence and into adulthood. Outcomes in terms of life expectancy and renal function are favorable.

A consensus statement on health-care transition of patients with childhood-onset chronic kidney diseases: providing adequate medical care in adolescence and young adulthood

“…Transfer from pediatric to adult care (1) Ensure that the transfer from pediatric to adult care does not cause disruption to advanced, high-quality medical care. …”

“…Necessary support by medical societies/associations (1) Regarding continued provision of medical care from pediatric to adult health-care services, identify financial problems and request the administrative personnel to provide adequate support.…”

“…In the field of pediatric renal diseases, many diseases, including but not limited to childhood-onset nephrotic syndrome, chronic glomerulonephritis such as IgA nephropathy, CAKUT, CKD due to various diseases, and ESKD, persist after patients become adults. More than half of the children with frequently relapsing nephrotic syndrome experience relapse even in adulthood and use immunosuppressants [1]. The median age at which CAKUT progresses to ESKD was reported to be around 35 years [2].…”

Glucocorticosteroid Therapy and Physical Developmentof Children With Steroid-Sensitive Nephrotic Syndrome: A Retrospective Study

“…По разным данным, частота развития ожи-рения составляет 35-43% [7]. Уменьшение дозы ГКС при-водит к уменьшению массы тела, но не у всех пациентов она приходит к норме по окончании терапии [8]. B. J.…”

“…Увеличение массы тела детей в период приема ГКС описано во многих исследованиях [6][7][8]. Повышение аппетита и связанное с ним увеличение массы тела отно-сятся к первым проявлениям побочного действия ГКС [13], наблюдаемым даже при применении их короткими (до 14 сут) курсами [14].…”