Morbidity of Retropubic Radical Prostatectomy for Prostate Cancer in Renal Transplant Recipients: Multicenter Study from Renal Transplantation Committee of French Urological Association

Kleinclauss, F.; Neuzillet, Y.; Tillou, X.; Terrier, N.; Guichard, G.; Petit, Jacques; Lechevallier, É.

doi:10.1016/j.urology.2008.03.018

Cited by 42 publications

(53 citation statements)

References 20 publications

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“…Currently, only limited series have been published about RLRP in renal transplant recipients [16,17,18,19,20,21,22,23]. The advantages of the robotic surgery can provide a useful minimally invasive tool for a more accurate dissection and procedure.…”

Section: Introductionmentioning

confidence: 99%

Robot Assisted Radical Prostatectomy in Kidney Transplant Recipients. Our Clinical Experience and a Systematic Review

et al. 2016

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Introduction: Radical prostatectomy is a more skillful procedure in kidney graft recipients. Robotic surgery can provide a useful minimally invasive tool. Objectives: The study aims to evaluate the robotic-assisted laparoscopic prostatectomy (RALP) in kidney transplant recipients, describing intra/postoperative complications, renal and oncological outcomes. Methods: This is a retrospective study conducted in a single institution of 84 RALP. Four of them were kidney transplant recipients. Side of the renal graft, clinical stage, intra/postoperative events, operating time, creatinine levels before/after intervention and oncologic follow-up were recorded. A systematic review of the literature was performed. Results: Aged 61.25 ± 7.76 years, interval between renal transplantation and RALP: 10 ± 3.16 years. Mean prostate specific antigen: 7.1 ± 2.8 ng/ml, 2 patients were cT1c and 2 cT2a. Preoperative biopsies: Gleason score 3 + 3 in 3 patients, 3 + 4 in 1 patient. Charlson comorbidity index mean was 4.82 ± 0.82. No intra/postoperative events were reported. Mean operating time: 196 ± 20.8 min. Positive surgical margins: 2/4 patients. Pathological analysis: Gleason 3 + 4 in 2 patients and Gleason 3 + 3 in the others 2. A patient developed a bladder neck sclerosis. No differences between pre/postoperative creatinine. Three patients are free of biochemical recurrence and 1 patient required adjuvant radiotherapy. Conclusion: RALP in renal transplant recipients is a safe and feasible technique for localized prostate cancer. No difference in oncological outcomes and no impairments on renal function were found.

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Section: Introductionmentioning

confidence: 99%

Robot Assisted Radical Prostatectomy in Kidney Transplant Recipients. Our Clinical Experience and a Systematic Review

et al. 2016

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“…10 Retropubic radical prostatectomy (RRP), according to the technique described by Walsh, has been studied in renal transplant recipients and has been the subject of several publications, including the multicentre Renal Transplantation Committee of French Urological Association study conducted between 1996 and 2007, which compared retropubic prostatectomy between renal transplant recipients (n = 20) and a control group (n = 40). 4 The main significant difference was an earlier age at diagnosis in the renal transplant population (60.4 vs. 64.4 years). No significant difference was observed between the two groups in terms of histology.…”

Section: Discussionmentioning

confidence: 95%

“…3 The functional and oncological results of radical prostatectomy in these patients remain poorly evaluated. The results of retropubic 4,5 and laparoscopic prostatectomy have been previously reported, [6][7][8] but few studies have evaluated robot-assisted laparoscopic prostatectomy. 9 We therefore evaluated the technical feasibility and oncological results of robot-assisted laparoscopic radical prostatectomy (RALP) in renal transplant recipients.…”

Section: Introductionmentioning

confidence: 99%

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Technical feasibility of robot-assisted laparoscopic radical prostatectomy in renal transplant recipients: Results of a series of 12 consecutive cases

Clerc¹,

Lecornet²,

Léon³

et al. 2015

CUAJ

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Introduction: We evaluate the technical feasibility of robotic prostatectomy in renal transplant recipients. Methods: We retrospectively analyzed preoperative and perioperative settings, as well as functional and oncologic results of 12 patients operated on between 2009 and 2013. Prostatectomy was performed via a transperitoneal approach without any changing in the ports position. The average age was 61.92 ± 2.98 years. The period between transplant and the diagnosis of adenocarcinoma was 79.7 months. The mean PSA was 7.34 ng/mL (range: 4.9-11). Results: The operative time was 241.3 ± 35.6 minutes with only one conversion and one transfusion. The intervention was difficult due to adhesions on the side of the graft in 50% of cases. There was a case of obstructive acute renal failure resulting from a hematoma of the Retzius treated by percutaneous nephrostomy at D20. There was a majority of pT2c (72.7%), including 3 positive margins (27.3%) and 2 biochemical relapses treated with radiotherapy and hormonotherapy, respectively. The end point prostate-specific antigen was undetectable. There was no significant difference between preoperative and J7 creatinine (p = 0. 22). Conclusions: Robotic prostatectomy in renal transplant recipients is a safe technique with no serious effects on the allograft. IntroductionFor patients with end-stage renal disease, renal transplantation is the best treatment in terms of patient survival and quality of life.1 However, the need for immunosuppressive therapy following transplantation increases the incidence of certain cancers, 2 including urological cancers. 3 Prostate cancer is the most common urological cancer in male renal transplant recipients, with an incidence of 3.1%. 3The functional and oncological results of radical prostatectomy in these patients remain poorly evaluated. The results of retropubic 4,5 and laparoscopic prostatectomy have been previously reported, 6-8 but few studies have evaluated robot-assisted laparoscopic prostatectomy. 9 We therefore evaluated the technical feasibility and oncological results of robot-assisted laparoscopic radical prostatectomy (RALP) in renal transplant recipients. MethodsThis single-centre retrospective study included 12 renal transplant recipients who underwent RALP between January 2009 and January 2013.Clinicom 2001 version 6.50.0102 (Cliniom, Inc.) was used for data collection and Fusion Pégase 4D version 4.0.0 (Fusion Pégase Inc.) was used for anesthetic data. RALP was performed according to the conventional technique with 6 transperitoneal trocars. Lymph node dissection was not performed on the side of the transplant.Clinical data (age at the time of prostatectomy, etiology of end-stage renal disease, interval between renal transplantation and prostatectomy, side of transplantation, immunosuppressive therapy, American Society of Anesthesiologists [ASA] score, body mass index [BMI], and Charlson comorbidity index) were recorded for each patient.The diagnosis of prostate cancer was established on the basis of digital rectal e...

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“…tions (15% vs. 2.5% in nontransplant patients) (59). However, to date, no series of RRP in RTRs have shown a significant increase in wound infection.…”

Section: Radical Retropubic Prostatectomy (Rrp)mentioning

confidence: 99%

Prostate cancer in renal transplant recipients

2015

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ARTIcLE InfO ______________________________________________________________ ______________________As patients with end-stage renal disease are receiving renal allografts at older ages, the number of male renal transplant recipients (RTRs) being diagnosed with prostate cancer (CaP) is increasing. Historically, the literature regarding the management of CaP in RTR's is limited to case reports and small case series. To date, there are no standardized guidelines for screening or management of CaP in these complex patients.To better understand the unique characteristics of CaP in the renal transplant population, we performed a literature review of PubMed, without date limitations, using a combination of search terms including prostate cancer, end stage renal disease, renal transplantation, prostate cancer screening, prostate specific antigen kinetics, immunosuppression, prostatectomy, and radiation therapy. Of special note, teams facilitating the care of these complex patients must carefully and meticulously consider the altered anatomy for surgical and radiotherapeutic planning. Active surveillance, though gaining popularity in the general low risk prostate cancer population, needs further study in this group, as does the management of advance disease. This review provides a comprehensive and contemporary understanding of the incidence, screening measures, risk stratification, and treatment options for CaP in RTRs.

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Morbidity of Retropubic Radical Prostatectomy for Prostate Cancer in Renal Transplant Recipients: Multicenter Study from Renal Transplantation Committee of French Urological Association

Cited by 42 publications

References 20 publications

Robot Assisted Radical Prostatectomy in Kidney Transplant Recipients. Our Clinical Experience and a Systematic Review

Robot Assisted Radical Prostatectomy in Kidney Transplant Recipients. Our Clinical Experience and a Systematic Review

Technical feasibility of robot-assisted laparoscopic radical prostatectomy in renal transplant recipients: Results of a series of 12 consecutive cases

Prostate cancer in renal transplant recipients

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