Morbidity related to maternal group B streptococcal infections

Muller, Anouk E.; Oostvogel, Paul M.; Steegers, Eric A.P.; Dörr, P. Joep

doi:10.1080/00016340600780508

Cited by 74 publications

(71 citation statements)

References 106 publications

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“…This is consistent with findings in other studies (Aungst et al, 2004, Le et al, 2004. However, several studies have reported high rates of GBS UTI in non-pregnant adults (Edwards&Baker, 2005, Falagas et al, 2006, Muller et al, 2006, Toumi et al, 2006. In one study, GBS was cultured from 39% of all cases of symptomatic UTI among nursing home residents >70 years of age (Trivalle et al, 1998).…”

Section: Prevalence Of Gbs In the Urinary Tractsupporting

confidence: 82%

“…Pyuria concurrently with bacteriuria constitutes diagnostic criteria in some settings (Shaikh et al, 2007), although what constitutes clinically significant bacteriuria is not strictly defined; colony counts >10 3 cfu/ml of a uropathogen is however, now widely accepted diagnostic criteria for cystitis (Nicolle, 2008, Rubin et al, 1992. Clinically, UTI due to GBS may be indistinguishable from UTI caused by other uropathogens (Muller et al, 2006). A recent study of multiple uropathogens highlighted unique frequencies of host characteristics in UTI groups defined by the causal organism (Tabibian et al, 2008).…”

Section: Diagnosis Of Gbs Utimentioning

confidence: 99%

“…Emerging trends in GBS disease incidence and prevalence strongly suggest that changes in the recognition and treatment of GBS infections are impacting the types of individuals affected by the bacterium and invasive disease in adults is now more common than in neonates (Baker, 2000. , Falagas et al, 2006, Muller et al, 2006. There are ten different capsular serotypes of GBS, namely Ia, Ib, and II-IX.…”

Section: Host Range and Gbs Serotypesmentioning

confidence: 99%

“…Approximately 2-7% of pregnant women exhibit ABU caused by GBS and GBS ABU during pregnancy is considered a surrogate marker for heavy maternal genital tract colonization (Liston et al, 1979, McKenna et al, 2003, Moller et al, 1984, Persson et al, 1986a, Wood&Dillon, 1981 and is indicated for intrapartum antibiotic chemoprophylaxis (McKenna et al, 2003, Schrag et al, 2002. In addition, up to 7% of pregnancies may be complicated by GBS UTI, and GBS reportedly accounts for approximately 10% of all cases of pyelonephritis during pregnancy (Muller et al, 2006, Persson et al, 1986a, Persson et al, 1986b. GBS UTI may also contribute to chorioamnionitis (Anderson et al, 2007), premature onset of labour (Moller et al, 1984), and an increased risk of vertical transmission of GBS (Persson et al, 1985, Wood&Dillon, 1981.…”

Section: Gbs Abu and Uti In Pregnancymentioning

confidence: 99%

See 3 more Smart Citations

Current Understanding of Streptococcal Urinary Tract Infection

Tan¹,

Carey²,

Ipe³

et al. 2011

Clinical Management of Complicated Urinary Tract Infection

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Section: Prevalence Of Gbs In the Urinary Tractsupporting

confidence: 82%

Section: Diagnosis Of Gbs Utimentioning

confidence: 99%

Section: Host Range and Gbs Serotypesmentioning

confidence: 99%

Section: Gbs Abu and Uti In Pregnancymentioning

confidence: 99%

See 2 more Smart Citations

Current Understanding of Streptococcal Urinary Tract Infection

Tan¹,

Carey²,

Ipe³

et al. 2011

Clinical Management of Complicated Urinary Tract Infection

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“…Many of these episodes represent ABU (2, 18); however, GBS ABU is considered to be a surrogate for heavy maternal colonization (29,42) and is currently recommended for intrapartum antibiotic chemoprophylaxis (23,34). In addition, up to 7% of pregnancies may be complicated by GBS UTI, and GBS reportedly accounts for approximately 10% of all cases of pyelonephritis during pregnancy (25,28). …”

mentioning

confidence: 99%

Diversity of Group B Streptococcus Serotypes Causing Urinary Tract Infection in Adults

Ulett¹,

Benjamin

Zhuo

et al. 2009

J Clin Microbiol

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Serotypes of group B streptococcus (GBS) that cause urinary tract infection (UTI) are poorly characterized.We conducted a prospective study of GBS UTI in adults to define the clinical and microbiological characteristics of these infections, including which serotypes cause disease. Patients who had GBS cultured from urine over a 1-year period were grouped according to symptoms, bacteriuria, and urinalysis. Demographic data were obtained by reviewing medical records. Isolates were serotyped by latex agglutination and multiplex PCRreverse line blotting (mPCR/RLB). Antibiotic susceptibilities were determined by disc diffusion. GBS was cultured from 387/34,367 consecutive urine samples (1.1%): 62 patients had bacteriuria of >10 7 CFU/liter and at least one UTI symptom; of these patients, 31 had urinary leukocyte esterase and pyuria (others not tested), 50 (81%) had symptoms consistent with cystitis, and 12 (19%) had symptoms of pyelonephritis. Compared with controls (who had GBS isolated without symptoms), a prior history of UTI was an independent risk factor for disease. Increased age was also significantly associated with acute infection. Serotyping results were consistent between latex agglutination and mPCR/RLB for 331/387 (85.5%) isolates; 22 (5.7%) and 7 (1.8%) isolates were nontypeable with antisera and by mPCR/RLB, respectively; and 45/56 (80.4%) isolates with discrepant results were typed by mPCR/RLB as belonging to serotype V. Serotypes V, Ia, and III caused the most UTIs; serotypes II, Ib, and IV were less common. Nontypeable GBS was not associated with UTI. Erythromycin (39.5%) and clindamycin (26.4%) resistance was common. We conclude that a more diverse spectrum of GBS serotypes causes UTI than previously recognized, with the exception of nontypeable GBS.Group B streptococcus (GBS) is a leading cause of infection in newborns, pregnant women, and older persons with chronic medical illness (3,8). In addition to maternal cervicovaginal colonization and neonatal infection that results from the vertical transmission of bacteria from mothers to their infants, GBS can also cause urinary tract infection (UTI). The spectrum of GBS UTI includes asymptomatic bacteriuria (ABU), cystitis, pyelonephritis, urethritis, and urosepsis (6,8,10,20,23,26). GBS ABU is particularly common among pregnant women, although those most at risk for cystitis due to GBS appear to be the elderly and immunocompromised individuals (8,9,25). Despite the uropathogenic nature of GBS, the clinical and microbiological features of GBS UTI, including risk factors for disease and whether there is a tendency for particular GBS serotypes to cause UTI, are poorly understood.Clinically, UTI due to GBS may be indistinguishable from UTI caused by other uropathogens (25). However, a recent study of multiple uropathogens and host characteristics highlighted unique frequencies of host characteristics in UTI groups defined by the causal organism (37). This suggests that the clinical and microbiological features of UTI may differ depending on the infecting...

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