30 patients were available (with the exception that 1 of the patients was not typed for the HLA-B locus), and for an additional 18 patients, HLA-B27 data were available. Of the 47 patients typed for B27, 13 (28%) were B27 positive. Twelve of the 48 patients had sacroiliitis, and 2 (17%) of them were B27 positive. These data suggest that Whipple's disease may be associated with HLA-B27, even in the absence of concomitant sacroiliitis.In 1979, Feurle and colleagues reported a possible association between Whipple's disease and an increased frequency of HLA-B27 antigen (1); 4 of their 9 patients (44%) expressed the B27 antigen, It is difficult, however, to draw conclusions from such a short series. There are now published and unpublished data on 48 patients