More attention should be paid to the treatment of male infertility with drugs-testosterone: to use it or not?

Li, Hong‐Jun

doi:10.4103/1008-682x.122343

Cited by 14 publications

(11 citation statements)

References 30 publications

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“…Concomitant disorders and infertility duration are identified as significant risk factors associated with psychological symptoms. Thus, andrologists, urologists, psychologists, counselors, and social workers should acknowledge the susceptibility of infertile Chinese men to depression and anxiety when they make a diagnosis and treatment plan for infertility ( Li, 2014 ). The authors hope this study helps to guide a future nationwide survey on the prevalence of psychological symptoms in Chinese men of reproductive age who are dealing with infertility.…”

Section: Discussionmentioning

confidence: 99%

Assessment on Occurrences of Depression and Anxiety and Associated Risk Factors in the Infertile Chinese Men

Yang

Zhang

et al. 2017

Am J Mens Health

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The prevalence of depression and anxiety in the Chinese male population with infertility is still uncertain. The prevalence of depression, anxiety, and a combination of both psychological symptoms was 20.8%, 7.8%, and 15.4%, respectively in 771 infertile Chinese men in the current study by the Mental Health Inventory–5 and the State–Trait Anxiety Inventory–Short Form questionnaires. Differences in demographics (age, education, and income) had no noticeable impact on the development of psychological symptoms. Clinical factors such as concomitant disorders (varicocele, epididymal cyst, and erectile dysfunction) were identified as risk factors associated with depressive symptoms (OR = 1.47; 95% CI [1.14, 1.90]; p < .001) and both depressive and anxiety symptoms (OR = 1.56; 95% CI [1.17, 2.08]; p < .001). An infertility duration over 2 years was associated with a high risk of anxiety symptoms (OR = 3.94; 95% CI [1.20, 12.93], p < .02). Other clinical conditions such as type of treatment and quality of sperm were not significant risk factors for psychological symptoms. This study provides evidence that Chinese men of reproductive age who suffer from infertility are vulnerable to psychological distress.

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Section: Discussionmentioning

confidence: 99%

Assessment on Occurrences of Depression and Anxiety and Associated Risk Factors in the Infertile Chinese Men

Yang

Zhang

et al. 2017

Am J Mens Health

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“…Grade D sperm % was positively correlated to MAD. Normal morphology sperm % was positively correlated to GSH, as shown in Table (4).…”

Section: Correlations Of Sperm Characteristics To Demographic Characteristics and Oxidative Markersmentioning

confidence: 82%

“…Assisted Reproductive Technologies (ART's) have become the treatment of choice in several cases for male and female infertility (2).Thus, the best sperm preparation technique is to achieve the foremost number of morphologically normal, motile spermatozoa in a tiny volume of physiological culture media free from seminal plasma, leukocytes and bacteria (3). Semen cryopreservation is one of the most effective and acceptable methods to maintain male fertility potential and considered a routine procedure in (ART) (4).This technique becomes particularly important in cases of preservation of male fertility before radiotherapy, cytotoxic chemotherapy, or certain surgical treatment (5), herbal drugs from naturopathy (Ayurveda, Sidha, Unani and Chin, Anese traditional medicine) are general to treat male infertility despite the lack of scientific experimentation to measure its effectiveness (6). Cucumic melo var.…”

Section: Introductionmentioning

confidence: 99%

The role of Cucumic Melo Varieta Agrestis, Vitamin C and Zinc on Sperm Activity and Oxidative Stress during Cryopreservation in Infertile Male

Waled¹,

Alwasiti²,

Sahib³

et al. 2019

ATMPH

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The objective of this study was to investigate the role of Cucumic melo varagrestis, Vitamin C and zinc on human spermatozoa and oxidative stress during cryopreservation in asthenozoospermia. One hundred males were participated in this study at Infertility Clinic at High Institute for Infertility Diagnosis and Assisted Reproductive Technologies/Al-Nahrain University. There ages were (31.86 ±0.76) years. Semen samples were collected and seminal fluid analysis was done according to WHO (1999). Cryopreservation kept for one month in liquid nitrogen (LN2) at (-196•C 1ml semen sample with 1ml of sperm freeze medium with zinc, vitamin c , cucmic melon extraction). After one month; 0.5 ml of Ferticuilt Flushin was added to pallet and incubation 37•C\30min and Microscopic sperm parameters Examination had conducted. The oral administration of antioxidant combination of Cucumic melo var. agrestis, vitamin C and zinc improves sperm characteristics in asthenozoospermia.

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“…Therefore, some experts suggest that empirical drug therapy, including androgens, for male infertility requires further research to generate related evidence. [ 36 ]…”

Section: Discussionmentioning

confidence: 99%

Effects of Saikokaryukotsuboreito on Spermatogenesis and Fertility in Aging Male Mice

Zang

Zhang

et al. 2016

Chinese Medical Journal

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Background:Aspermia caused by exogenous testosterone limit its usage in late-onset hypogonadism (LOH) patients desiring fertility. Saikokaryukotsuboreito (SKRBT) is reported to improve serum testosterone and relieve LOH-related symptoms. However, it is unclear whether SKRBT affects fertility. We aimed to examine the effects of SKRBT on spermatogenesis and fertility in aging male mice.Methods:Thirty aging male mice were randomly assigned to three groups. Mice were orally administered with phosphate-buffer solution or SKRBT (300 mg/kg, daily) or received testosterone by subcutaneous injections (10 mg/kg, every 3 days). Thirty days later, each male mouse was mated with two female mice. All animals were sacrificed at the end of 90 days. Intratesticular testosterone (ITT) levels, quality of sperm, expression of synaptonemal complex protein 3 (SYCP3), and fertility were assayed.Results:In the SKRBT-treated group, ITT, quality of sperm, and expression of SYCP3 were all improved compared with the control group (ITT: 85.50 ± 12.31 ng/g vs. 74.10 ± 11.45 ng/g, P = 0.027; sperm number: [14.94 ± 4.63] × 106 cells/ml vs. [8.79 ± 4.38] × 106 cells/ml, P = 0.002; sperm motility: 43.16 ± 9.93% vs. 33.51 ± 6.98%, P = 0.015; the number of SYCP3-positive cells/tubule: 77.50 ± 11.01 ng/ml vs. 49.30 ± 8.73 ng/ml, P < 0.001; the expression of SYCP3 protein: 1.23 ± 0.09 vs. 0.84 ± 0.10, P < 0.001), but fertility was not significantly changed (P > 0.05, respectively). In the testosterone-treated group, ITT, quality of sperm, and expression of SYCP3 were markedly lower than the control group (ITT: 59.00 ± 8.67, P = 0.005; sperm number: [4.34 ± 2.45] × 106 cells/ml, P = 0.018; sperm motility: 19.53 ± 7.69%, P = 0.001; the number of SYCP3-positive cells/tubule: 30.00 ± 11.28, P < 0.001; the percentage of SYCP3-positive tubules/section 71.98 ± 8.88%, P = 0.001; the expression of SYCP3 protein: 0.71 ± 0.09, P < 0.001), and fertility was also suppressed (P < 0.05, respectively).Conclusion:SKRBT had no adverse effect on fertility potential in aging male mice.

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More attention should be paid to the treatment of male infertility with drugs-testosterone: to use it or not?

Cited by 14 publications

References 30 publications

Assessment on Occurrences of Depression and Anxiety and Associated Risk Factors in the Infertile Chinese Men

Assessment on Occurrences of Depression and Anxiety and Associated Risk Factors in the Infertile Chinese Men

The role of Cucumic Melo Varieta Agrestis, Vitamin C and Zinc on Sperm Activity and Oxidative Stress during Cryopreservation in Infertile Male

Effects of Saikokaryukotsuboreito on Spermatogenesis and Fertility in Aging Male Mice

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