More gain, less pain: How resistance training affects immune system functioning in multiple sclerosis patients: A review

Exploring the impact of exercise and essential amino acid plus cholecalciferol supplementation on physical fitness and body composition in multiple sclerosis: A case study

“…Recent research has explored non‐pharmacological treatments such as exercise, nutritional supplementation, and improved sleep quality 14–21 . Resistance exercise (RE) is particularly beneficial for MS rehabilitation as it improves muscle strength and function, mobility, quality of life, 22,23 and the immune system 24 . High‐dose vitamin D supplementation raises interleukin‐10 (IL‐10) levels in MS patients, 19 who tend to have lower levels of IL‐10, which may contribute to the development of the disease 25 .…”

“… 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 Resistance exercise (RE) is particularly beneficial for MS rehabilitation as it improves muscle strength and function, mobility, quality of life, 22 , 23 and the immune system. 24 High‐dose vitamin D supplementation raises interleukin‐10 (IL‐10) levels in MS patients, 19 who tend to have lower levels of IL‐10, which may contribute to the development of the disease. 25 However, RE and vitamin D may not always improve physical fitness.…”

A Case Study on the Impact of Exercise and Essential Amino Acid Supplementation on Physical Fitness and Body Composition

“…Recent research has explored non-pharmacological treatments such as exercise, nutritional supplementation, and improved sleep quality [14][15][16][17][18][19][20][21] . Resistance exercise (RE) is particularly beneficial for MS rehabilitation, as it improves muscle strength and function, mobility, quality of life 22,23 , and the immune system 24 . Highdose vitamin D supplementation raises interleukin-10 (IL-10) levels in MS patients 19 , who tend to have lower levels of IL-10, which may contribute to the disease's development 25 .…”

Interventions to Improve Quality of Life in Multiple Sclerosis: New Opportunities and Key Talking Points

“…56,57 There are non-pharmacological interventions with recent and notable evidence demonstrating effectiveness with fatigue management through exercise, CBT, massage, and neuromodulation therapies. 22,24,[29][30][31][32][33][34][35][36][37] Intervention studies in this review included three RCTs, one quasi-experimental trial, and a randomized prospective longitudinal pilot study. Four studies specifically looked at some form of exercise and its impact on fatigue and overall quality of life.…”

“…24 In the same study, cognitive behavioral therapy (CBT) was said to have a large effect on reducing fatigue 24 Amin, N. et al, in a 2023 narrative review on resistance training, reported that overall well-being and quality of life increases when pwMS engage in resistance training, again demonstrating the benefits of exercise. 29 One position paper summed up the evidence by concluding that exercise and cognitive behavioral therapy should be prioritized for fatigue treatment in all pwMS. 35 There is a notable lag in translating this large body of evidence on exercise and quality of life into clinical practice.…”