More siblings, less hay fever: more evidence

Marshall, Andrew; Owen, Victoria Jane; Jones, Nicholas S.

doi:10.1046/j.1365-2273.2002.00594.x

Cited by 5 publications

(3 citation statements)

References 51 publications

(47 reference statements)

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“…Better hygiene or fewer respiratory infections, and possibly closer attention paid to milder symptoms when a first‐born child is concerned, may both partly explain this difference. Our finding is in accordance with other reports of lower occurrences of allergic diseases associated with the presence and number of siblings (35, 39, 41).…”

Section: Discussionsupporting

confidence: 94%

“…In the German birth cohort study (MAS), IgE concentrations were found to increase up to the age of 10, with higher values in boys than in girls (34). Several other studies (35)(36)(37)(38), with one exception (39), have also found male gender to be associated with an increased risk of allergic diseases, and the cohort study from the Isle of Wight reported a similar gender difference for FAs (40), whereas a Swedish study reported higher prevalence of FA among girls (35). In our results this difference was apparent only in FA, but not in FHS.…”

Section: Discussionmentioning

confidence: 99%

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Occurrence of parent‐reported food hypersensitivities and food allergies among children aged 1–4 yr

Pyrhönen

Näyhä

Kaila

et al. 2009

Pediatric Allergy Immunology

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Food allergies (FAs) and hypersensitivities (FHSs) have rarely been studied in large unselected child populations. This population-based cross-sectional survey estimated the occurrence of FHS as perceived by parents and that of FA diagnosed by a physician among children aged 1-4 yr in south-eastern Finland. Before the scheduled annual follow-up visit to the local child health clinic, the parents of children who were born between 1 April, 2001 and 31 March, 2005, and living in the Province of South Karelia (data from Finnish Population Register) were mailed a questionnaire containing items on the child's background, physician-diagnosed FAs and FHSs perceived by the parents. The questionnaires were returned during the visit. Three thousand three hundred and eight (69%) out of the 4779 questionnaires were returned. The lifetime prevalence of physician-diagnosed FAs was 9%. In an additional 21%, FHSs were perceived by the parents only. In a further 19% at least one food item had been eliminated from the diet without any perception of symptoms, this proportion having a downward trend by age. Physician-diagnosed FAs were more common in boys than in girls. Cow's milk was the most commonly reported cause of food-associated symptoms (13% of all children). One-third of the children aged 1-4 yr suffered from food-associated symptoms, and in an additional fifth at least one food item had been eliminated from their diet, implying that every other child had possibly been subjected to some form of elimination diet.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Occurrence of parent‐reported food hypersensitivities and food allergies among children aged 1–4 yr

Pyrhönen

Näyhä

Kaila

et al. 2009

Pediatric Allergy Immunology

View full text Add to dashboard Cite

show abstract

“…The odds of having hay fever were less for individuals with two or more siblings. 17 Recall bias could have influenced the results. In a European cohort study, atopy, defined by prick tests to common aeroallergens, was less common among those from larger families.…”

Section: Evidence For and Against The Hygiene Hypothesismentioning

confidence: 99%