2017
DOI: 10.1080/19336896.2017.1356559
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More stressed out with age? Check your RNA granule aggregation

Abstract: ABSTRACT. Low complexity (LC) prion-like domains are over-represented among RNAbinding proteins (RBPs) and contribute to the dynamic nature of RNA granules. Importantly, several neurodegenerative diseases are characterized by cytoplasmic "solid" aggregates formed by mainly nuclear RBPs harboring LC prion-like domains. Although RBP aggregation in disease has been extensively characterized, it remains unknown how the process of aging disturbs RBP dynamics. Our recent study revealed that RNA granule components in… Show more

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Cited by 22 publications
(22 citation statements)
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“…These aberrant SGs may accelerate the aging process and aging-associated diseases. In aged C. elegans , the SG proteins PAB-1 and TIAR-2 can form aggregates, associated with shorter lifespan [ 63 ], suggesting a connection between SG protein aggregation and shorter lifespan. An abnormal protein-RNA interaction may lead these proteins to be aggregated and form irreversible aggregations [ 64 ], leading to persistent SGs, which would cause the pathogenesis of aging-related diseases [ [65] , [66] , [67] ].…”
Section: Sgs and Human Diseasesmentioning
confidence: 99%
“…These aberrant SGs may accelerate the aging process and aging-associated diseases. In aged C. elegans , the SG proteins PAB-1 and TIAR-2 can form aggregates, associated with shorter lifespan [ 63 ], suggesting a connection between SG protein aggregation and shorter lifespan. An abnormal protein-RNA interaction may lead these proteins to be aggregated and form irreversible aggregations [ 64 ], leading to persistent SGs, which would cause the pathogenesis of aging-related diseases [ [65] , [66] , [67] ].…”
Section: Sgs and Human Diseasesmentioning
confidence: 99%
“…The effect of lipoic acid on stress granule protein aggregation in vivo was analysed using a C. elegans model for stress granule formation and aggregation. As previously described 53,79 , fluorescent-tagged PAB-1 forms abundant stress granules and large solid aggregates during aging or upon chronic stress. were maintained at at 20°C.…”
Section: Protein Aggregation In C Elegansmentioning
confidence: 99%
“…In contrast, both KIN-19 and RHO-1 are highly structured globular proteins, which are intrinsically prone to aggregate shortly after synthesis [22]. Notably, the divergent aggregation processes are controlled by different mechanisms [23, 38, 39]. Unlike KIN-19 or RHO-1 aggregation, PAB-1 aggregation in the pharynx was accelerated by inhibition of chaperones (as previously described [23]), proteasome and autophagy systems (Fig.…”
Section: Resultsmentioning
confidence: 90%
“…Next, we investigated whether SAPA is effective in preventing the aggregation of RNA-binding protein polyadenylate-binding protein 1 (PAB-1). PAB-1 contains a low complexity prion-like domain and undergoes liquid-liquid phase separation to form stress granules, putting it at risk of aggregating during aging or chronic stress in C. elegans [23, 38] . In contrast, both KIN-19 and RHO-1 are highly structured globular proteins, which are intrinsically prone to aggregate shortly after synthesis [22].…”
Section: Resultsmentioning
confidence: 99%
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