This study investigates the integration of ISO 26262 with Vehicle-to-Everything (V2X) communication technologies. Emphasize the necessity of expanding this safety standard to include vehicle-to-infrastructure integration and addressing additional safety measures to accommodate current vehicles’ complex and rapidly evolving networks. The study uses an extensive review approach, which considers existing safety pro-tocols and a qualitative literature synthesis to evaluate current standards and anticipate future requirements from them. It also looks at developments in V2X communication technology while identifying gaps within the present scope of ISO 26262 concerning autonomous and connected cars. The findings indicate a significant improvement in road safety plus efficiency in traffic management by integrating ISO 26262 with V2X communication. Further, the research points out areas such as security lapses, real-time data processing deficiencies, interoperability hitches, and scalability limits. These findings call for amendments to current safety standards so that they can take care of those problems. Failure to include V2X into ISO 26262 may com-promise reliability altogether, hence posing a grave danger to future intelligent transportation systems (ITS)’s dependability. The research concludes that integrating them will help lower risks brought about by the dynamic nature of vehicles’ environment, thereby facilitating the establishment of globally solid and safe systems for communicating between vehicles.