Morin Exerts Anti‐Arthritic Effects by Attenuating Synovial Angiogenesis via Activation of Peroxisome Proliferator Activated Receptor‐γ

Abstract

Morin is a potential agonist of PPARγ, which attenuates synovial angiogenesis and arthritis via the PPARγ-PTEN-PI3K/Akt pathway.

Morin Acts as a USP7 Inhibitor to Hold Back the Migration of Rheumatoid Arthritis Fibroblast‐Like Synoviocytes in a “Prickle1‐mTORC2” Dependent Manner

“…RA‐FLS were obtained from synovial tissues of rats with AIA and prepared as described in our previous study. [ 18 ] In brief, synovial tissues were minced into small pieces and incubated with 0.4% type II collagenase for 4 h. After overnight culture, the adherent cells were cultured in DMEM supplemented with 15% FBS at 37°C under a humidified atmosphere of 5% CO 2 . The cells used in the experiments were from the third to the sixth generation.…”

“…Morin (3, 5, 7, 2’, 4’‐pentahydroxyflavone), a natural flavonoid, was originally isolated from members of the Moraceae family and further found in multiple kinds of small plants, fruits and wine. [ 17 ] Recently, our studies indicated that morin significantly inhibited collagen II‐induced arthritis in rats with unclear mechanisms; [ 18 ] Chen et al. reported an improvement of morin in osteoarthritis by inhibiting cartilage degradation.…”

PPARs and Angiogenesis—Implications in Pathology

“…In another small clinical trial, pioglitazone only modestly reduced rheumatoid arthritis disease activity [ 137 ] and vascular function [ 138 ]. Morin, a flavonoid from dietary plants was identified as PPARγ agonist, which attenuates synovial angiogenesis and arthritis via the PPARγ-PTEN-PI3K/Akt pathway [ 139 ].…”

Morin exerts anti-metastatic, anti-proliferative and anti-adhesive effect in ovarian cancer cells: an in vitro studies

“…An interesting example includes anti-cancer compounds known as flavones. Morin (2′,3,4′,5,7-pentahydroxyflavone), a member of the flavanol group [16] exist in high concentrations in many plants such as Morus alba L. (Moraceae) and Otostegia persica (Lamiaceae), and it also exists in figs, apples, onions, tea and cereal grains [17]. The presence of two aromatic rings connected by a c-pyrone ring, in which polar hydroxyl groups are bound at various positions to characterize the chemical structure of morin.…”