Morin hydrate protects type-2-diabetic wistar rats exposed to diesel exhaust particles from inflammation and oxidative stress

Lawal, Akeem O.; Folorunso, Ibukun Mary; Iwaloye, Opeyemi

doi:10.1007/s40200-022-01057-5

Cited by 8 publications

(7 citation statements)

References 64 publications

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“…This result about MET is in accord with previous studies (Cao et al, 2019; Yang et al, 2020), but as far as we know, no in vivo studies have shown the effects of MOR on Akt activity in the skeletal muscle. However, increased Akt activity following MOR treatment has been well demonstrated in other insulin‐sensitive tissues, such as liver and pancreas (Gu et al, 2017; Lawal et al, 2022; Tehrani et al, 2023). Also, in a study on L6 cell line, Issac et al showed that treatment with MOR increases glucose uptake through the insulin‐dependent pathway (Issac et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, Lee et al Demonstrated that MOR through the Nrf2/HO‐1‐dependent signaling significantly protects ROS generation in H 2 O 2 ‐treated C2C12 myoblasts. Furthermore, Lawal et al indicated that MOR reversed oxidative stress in the pancreas of T2DM rats through increasing the antioxidant enzymes and reducing MDA levels (Lawal et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

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Combination therapy of metformin and morin attenuates insulin resistance, inflammation, and oxidative stress in skeletal muscle of high‐fat diet‐fed mice

Bahramzadeh,

Samavarchi Tehrani,

Goodarzi

et al. 2023

Phytotherapy Research

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Lipid accumulation, inflammation, and oxidative stress are the most important causes of muscle insulin resistance. The aim of this study was to investigate the single and combined treatment effects of metformin (MET) and morin (MOR) on lipid accumulation, inflammation, and oxidative stress in the skeletal muscle of mice fed a high‐fat diet. The mice were supplemented with MET (230 mg/kg diet), MOR (100 mg/kg diet), and MET + MOR for 9 weeks. Our results revealed that single treatment with MET or MOR, and with a stronger effect of MET + MOR combined treatment, reduced body weight gain, improved glucose intolerance and enhanced Akt phosphorylation in the muscle tissue. In addition, plasma and muscle triglyceride levels were decreased after treatment with MET and MOR. The expression of genes involved in macrophage infiltration and polarization and pro‐inflammatory cytokines showed that MET + MOR combined treatment, significantly reduced inflammation in the muscle. Furthermore, combined treatment of MET + MOR with greater efficacy than the single treatment improved several oxidative stress markers in the muscle. Importantly, combined treatment of MET and MOR could increase the expression of nuclear factor erythroid 2–related factor 2, the master regulator of the antioxidant response. These findings suggest that combination of MET with MOR might ameliorate insulin resistance, inflammation, and oxidative stress in the skeletal muscle of mice fed high‐fat diet.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Combination therapy of metformin and morin attenuates insulin resistance, inflammation, and oxidative stress in skeletal muscle of high‐fat diet‐fed mice

Bahramzadeh,

Samavarchi Tehrani,

Goodarzi

et al. 2023

Phytotherapy Research

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“…Recently, as problems caused by fine dust have increased, many problems have occurred, and diabetics are more adversely affected than ordinary patients. When diabetic rats are exposed to fine dust, oxidative stress occurs, increasing the expression of infectious cytokines such as IL-1b, TNF-a, and IL-6 and decreasing the expression of anti-inflammatory cytokines such as IL-10, cyclooxygenase-2 (COX-2), delaying wound healing, and inhibiting glucose absorption in the pancreas [28,29]. When diabetic rats are exposed to DEPs, oxidative stress occurs; the expression levels of pro-inflammatory cytokines such as TNF-α, IL-6, and cyclooxygenase-2 (COX-2) increase, delaying the healing of diabetic wounds [30,31].…”

Section: Discussionmentioning

confidence: 99%

Effect of the Combination of Probiotics and Korean Red Ginseng on Diabetic Wound Healing Exposed to Diesel Exhaust Particles(DEPs)

Choi

Bae

et al. 2023

Medicina

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Background and Objectives: Diesel exhaust particles (DEPs) are a major component of air pollution and adversely affect respiratory and cardiovascular disease and diabetic foot ulcers if diabetic patients are exposed to them. There are currently no studies on treating diabetic wounds exposed to DEPs. So, the effect of a combination of probiotics and Korean red ginseng on a diabetic wound model exposed to DEPs was confirmed. Materials and Methods: Rats were randomly divided into three groups according to DEP inhalation concentration and whether they underwent applications of probiotics (PB) and Korean red ginseng (KRG). Wound tissue was collected from all rats, and wound healing was evaluated using molecular biology and histology methods. Results: The wound size of all groups decreased over time, but there was no significant difference. As a result of the molecular biology experiment, the expression of NF-κB p65 on day 7 was significantly higher in group 2 than in the normal control group. As a result of histological analysis, unlike the primary control group, it was confirmed that granule tissue was formed on the 14th day in the normal control group and group 2. Conclusions: The findings in this study suggest that combined treatment with PB and KRG can promote the healing of DEP-exposed diabetic wounds.

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“…Another study reported that morin prevents experimental rats from pancreatitis by reducing overall inflammation and tissue damage in pancreatic cells through alterations in lipid peroxidation, insulin secretion, and glucose metabolism 91 . Recently, morin hydrate was found to reduce inflammation, oxidative stress, fibrosis, and necrosis in the pancreas of the diabetic model of rats 128 . These studies indicate morin's antidiabetic and antiinflammatory potential by preventing hyperglycemia‐associated apoptosis, cellular stress, and mitochondrial dysfunctions.…”

Section: Role Of Selected Flavonols and Their Derivatives In Mitigati...mentioning

confidence: 96%

“…91 Recently, morin hydrate was found to reduce inflammation, oxidative stress, fibrosis, and necrosis in the pancreas of the diabetic model of rats. 128 These studies indicate morin's antidiabetic and antiinflammatory potential by preventing hyperglycemia-associated apoptosis, cellular stress, and mitochondrial dysfunctions. The therapeutic role of morin in inducing mitophagy and combating tumorigenesis and inflammation by regulating ECM modulation remains to be studied in cancer.…”

Section: Morinmentioning

confidence: 96%

Role of bio‐flavonols and their derivatives in improving mitochondrial dysfunctions associated with pancreatic tumorigenesis

Sharma,

Arora,

Bansal

et al. 2024

Cell Biochemistry & Function

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Mitochondria, a cellular metabolic center, efficiently fulfill cellular energy needs and regulate crucial metabolic processes, including cellular proliferation, differentiation, apoptosis, and generation of reactive oxygen species. Alteration in the mitochondrial functions leads to metabolic imbalances and altered extracellular matrix dynamics in the host, utilized by solid tumors like pancreatic cancer (PC) to get energy benefits for fast‐growing cancer cells. PC is highly heterogeneous and remains unidentified for a longer time because of its complex pathophysiology, retroperitoneal position, and lack of efficient diagnostic approaches, which is the foremost reason for accounting for the seventh leading cause of cancer‐related deaths worldwide. PC cells often respond poorly to current therapeutics because of dense stromal barriers in the pancreatic tumor microenvironment, which limit the drug delivery and distribution of antitumor immune cell populations. As an alternative approach, various natural compounds like flavonoids are reported to possess potent antioxidant and anticancerous properties and are less toxic than current chemotherapeutic drugs. Therefore, we aim to summarize the current state of knowledge regarding the pharmacological properties of flavonols in PC in this review from the perspective of mitigating mitochondrial dysfunctions associated with cancer cells. Our literature survey indicates that flavonols efficiently regulate cellular metabolism by scavenging reactive oxygen species, mitigating inflammation, and arresting the cell cycle to promote apoptosis in tumor cells via intrinsic mitochondrial pathways. In particular, flavonols proficiently inhibit the cancer‐associated proliferation and inflammatory pathways such as EGFR/MAPK, PI3K/Akt, and nuclear factor κB in PC. Overall, this review provides in‐depth evidence about the therapeutic potential of flavonols for future anticancer strategies against PC; still, more multidisciplinary human interventional studies are required to dissect their pharmacological effect accurately.

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Morin hydrate protects type-2-diabetic wistar rats exposed to diesel exhaust particles from inflammation and oxidative stress

Cited by 8 publications

References 64 publications

Combination therapy of metformin and morin attenuates insulin resistance, inflammation, and oxidative stress in skeletal muscle of high‐fat diet‐fed mice

Combination therapy of metformin and morin attenuates insulin resistance, inflammation, and oxidative stress in skeletal muscle of high‐fat diet‐fed mice

Effect of the Combination of Probiotics and Korean Red Ginseng on Diabetic Wound Healing Exposed to Diesel Exhaust Particles(DEPs)

Role of bio‐flavonols and their derivatives in improving mitochondrial dysfunctions associated with pancreatic tumorigenesis

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