Morin inhibits interleukin-1β-induced nitric oxide and prostaglandin E2 production in human chondrocytes

Chen, Weiping; Wang, Yulu; Tang, Jun; Hu, Pengfei; Bao, Jiapeng; Wu, Lidong

doi:10.1016/j.intimp.2011.12.024

Cited by 43 publications

(25 citation statements)

References 38 publications

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“…Another reason for the beneficial effects of morin is the reported anti-inflammatory properties, which were demonstrated in earlier in vitro and in vivo studies [45,47] . Recently Chen et al reported that the morin treatments suppress the production of several pro-inflammatory biomarkers expressions such as NO, PGE-2, iNOS and COX-2 [48]. Our findings showed similar results where the higher dose of morin (30 mg/kg) produced significant inhibition against the elevated pro-inflammatory cytokines such as TNF-α, IL-6 and IL-1β in experimentally-induced diabetic rats.…”

Section: Discussionsupporting

confidence: 88%

Ameliorative Potential of Morin in Streptozotocin-Induced Neuropathic Pain in Rats

AlSharari¹,

Al-Rejaie²,

Abuohashish³

et al. 2014

Trop. J. Pharm Res

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Purpose: To investigate the protective effect of morin, a naturally occurring bioflavonoid of Moraceae family, in experimentally-induced diabetic neuropathy (DN) in rats. Methods: Diabetes was induced by a single injection (65 mg/kg, ip) of streptozotocin (STZ SOD (1.08 ± 0.16) and CAT (2.77 ± 0.36) in sciatic nerve of diabetic rats also found corrections (2.09 ± 0.11, p < 0.01) and (4.53 ± 0.57, p < 0.01)

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Section: Discussionsupporting

confidence: 88%

Ameliorative Potential of Morin in Streptozotocin-Induced Neuropathic Pain in Rats

AlSharari¹,

Al-Rejaie²,

Abuohashish³

et al. 2014

Trop. J. Pharm Res

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“…COX‐2, known as the rate‐limiting enzyme, could produce the inflammatory mediator PGE2 in chondrocytes . Furthermore, IL‐1β could upregulate the expression levels of iNOS and COX‐2, which promote the production of NO and PGE2 in OA chondrocytes . The current study demonstrated that salidroside dose dependently inhibited the production of NO and PGE2, as well as decreased the expression of iNOS and COX‐2 in human OA chondrocytes.…”

Section: Discussionsupporting

confidence: 52%

Salidroside attenuates interleukin‐1β‐induced inflammation in human osteoarthritis chondrocytes

Zhang

Zhao

2018

J of Cellular Biochemistry

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Salidroside, a bioactive constituent isolated from Rhodiola rosea, has been reported to have anti‐inflammatory effects. However, the effects of salidroside on interleukin (IL)‐1β‐stimulated osteoarthritis (OA) chondrocytes remain to be elucidated. Thus, this study aimed to evaluate the anti‐inflammatory effects of salidroside on IL‐1β‐stimulated human OA chondrocytes and explore its underlying mechanisms. Our results showed that salidroside significantly inhibited the production of nitric oxide and prostaglandin E‐2, as well as suppressed the expression of inducible nitric oxide synthase and cyclooxygenase‐2 in IL‐1β‐stimulated chondrocytes ( P < .05). In addition, salidroside also suppressed IL‐1β‐induced matrix metalloproteinases production in human OA chondrocytes ( P < .05). Furthermore, pretreatment with salidroside prevented IL‐1β‐induced NF‐κB activation in OA chondrocytes ( P < .05). In conclusion, the current study demonstrated that salidroside inhibited the IL‐1β‐induced inflammatory response in OA chondrocytes via inhibition of NF‐κB activation.

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“…These results suggested that morin exhibited its anti-inflammatory response in chondrocytes through activation of the Nrf2 signaling pathway. Previous studies demonstrated that morin inhibit IL-1β-induced inflammatory mediator production in human chondrocytes by inhibiting NF-κB activation [19]. However, the precise molecular mechanism remains unclear.…”

Section: Discussionmentioning

confidence: 98%

“…Morin also has protective effects against cisplatininduced kidney injury in mice [18]. In addition, morin has been reported to inhibit IL-1β-induced inflammatory mediator production in human chondrocytes [19]. However, the anti-inflammatory mechanism of morin on OA remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Morin Exhibits Anti-Inflammatory Effects on IL-1β-Stimulated Human Osteoarthritis Chondrocytes by Activating the Nrf2 Signaling Pathway

Wang

Liu

et al. 2018

Cell Physiol Biochem

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Background/Aims: Osteoarthritis (OA) is a multifactorial disease that is associated with inflammation in joints. The purpose of the present study was to investigate the anti-inflammatory activity and mechanism of morin on human osteoarthritis chondrocytes stimulated by IL-1β. Methods: The levels of NO and PGE2 were measured by the Griess method and ELISA. The levels of MMP1, MMP3, and MMP13 were also measured by ELISA. Results: The results revealed that IL-1β significantly increased the production of NO, PGE2, MMP1, MMP3, and MMP13. Additionally, the increases were significantly attenuated by treatment with morin. Furthermore, IL-1β-induced NF-κB activation was suppressed by morin. In addition, the expression of Nrf2 and HO-1 were increased by morin and knockdown of Nrf2 could prevent the anti-inflammatory effects of morin. Conclusion: In conclusion, this study suggested that morin attenuated IL-1β-induced inflammation by activating the Nrf2 signaling pathway.

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Morin inhibits interleukin-1β-induced nitric oxide and prostaglandin E2 production in human chondrocytes

Cited by 43 publications

References 38 publications

Ameliorative Potential of Morin in Streptozotocin-Induced Neuropathic Pain in Rats

Ameliorative Potential of Morin in Streptozotocin-Induced Neuropathic Pain in Rats

Salidroside attenuates interleukin‐1β‐induced inflammation in human osteoarthritis chondrocytes

Morin Exhibits Anti-Inflammatory Effects on IL-1β-Stimulated Human Osteoarthritis Chondrocytes by Activating the Nrf2 Signaling Pathway

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