Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect

Thomas, Sithara; Arun, K. B.; Syama, H. P.; Reshmitha, T. R.; Nisha, P.

doi:10.3389/fphar.2017.00640

Cited by 55 publications

(48 citation statements)

References 73 publications

(77 reference statements)

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“…Mertoterpenoids are natural products of mixed biosynthetic origin which are partially derived from terpenoids. Meroterpenoids were also found in quinoa that include tocopherols (141-144) and tocotrienols (145,146). Their biological activities are listed in Table 18, and the structures are shown in Figure 21.…”

Section: Meroterpenoids and Their Biological Activities Or Functionsmentioning

confidence: 99%

Quinoa Secondary Metabolites and Their Biological Activities or Functions

et al. 2019

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Quinoa (Chenopodium quinoa Willd.) was known as the “golden grain” by the native Andean people in South America, and has been a source of valuable food over thousands of years. It can produce a variety of secondary metabolites with broad spectra of bioactivities. At least 193 secondary metabolites from quinoa have been identiﬁed in the past 40 years. They mainly include phenolic acids, ﬂavonoids, terpenoids, steroids, and nitrogen-containing compounds. These metabolites exhibit many physiological functions, such as insecticidal, molluscicidal and antimicrobial activities, as well as various kinds of biological activities such as antioxidant, cytotoxic, anti-diabetic and anti-inﬂammatory properties. This review focuses on our knowledge of the structures, biological activities and functions of quinoa secondary metabolites. Biosynthesis, development and utilization of the secondary metabolites especially from quinoa bran were prospected.

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Section: Meroterpenoids and Their Biological Activities Or Functionsmentioning

confidence: 99%

Quinoa Secondary Metabolites and Their Biological Activities or Functions

et al. 2019

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“…Apoptosis is a critical homeostatic mechanism involved in anti-cancer drug-induced proliferation inhibition (35). The mitochondrial apoptotic pathway has a critical role in drug-mediated apoptosis and is often regarded as a potential anti-cancer target (39–41). Bcl-2 family protein members, including Bax and Bcl-2, serve important roles in the mitochondrial apoptotic pathway.…”

Section: Discussionmentioning

confidence: 99%

Alantolactone induces gastric cancer BGC‑823 cell apoptosis by regulating reactive oxygen species generation and the AKT signaling pathway

Zhang

2019

Oncol Lett

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Alantolactone (ALT), a natural sesquiterpene lactone, has been suggested to exert anti-cancer activities in various cancer cell lines. However, the effects and mechanisms of action of ALT in human gastric cancer remains to be elucidated. In the present study, the effects of ALT on BGC-823 cells were examined and the underlying molecular mechanisms associated with these effects were investigated. Cell viability was detected by using an MTT assay. Cell cycle, cell apoptosis and the level of reactive oxygen species (ROS) were assessed by flow cytometry, and the expression levels of proteins of interest were analyzed by western blot assay. The results demonstrated that ALT triggered apoptosis and induced G0/G1 phase arrest in a dose-dependent manner. Furthermore, the expression level of the anti-apoptosis protein Bcl-2 was downregulated, and expression of the pro-apoptosis proteins Bax and cleaved PARP were significantly upregulated. The cell cycle-associated proteins cyclin-dependent kinase inhibitor 1 and cyclin-dependent kinase inhibitor 1B were also increased, while cyclin D1 was deceased. In addition, ALT induced apoptosis via the inhibition of RAC-alpha serine/threonine-protein kinase (AKT) signaling and ROS generation, which was effectively inhibited by the ROS scavenger, N-acetyl cysteine. Therefore, the results from the present study indicated that the ROS-mediated inhibition of the AKT signaling pathway serves an important role in ALT-induced apoptosis in BGC-823 cells. In conclusion, the results demonstrated that ALT exerted significant anti-cancer effects against gastric cancer cells in vitro .

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“…Morin is a flavonoid primarily identified in the leaves of common guava, onion and almonds, and in members of the Moraceae family, including mulberry, figs and Chinese herbs. The pro-oxidative effect of morin in SW480 cells results in a disturbance of the mitochondrial function, which results in the activation of the intrinsic and the extrinsic apoptosis pathways (56). Additionally, morin induces a significant reduction in glucose transporter-1 expression, which results in a decline in cellular glucose uptake, resulting in an impaired mitochondrial function, which further sensitizes cells to undergo apoptosis via the intrinsic apoptosis pathway (56).…”

Section: Phenolic Compoundsmentioning

confidence: 99%

Potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer (Review)

et al. 2019

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Colorectal cancer (CRC) is one of the leading causes of mortality among men and women. Chemo-resistance, adverse effects and disease recurrence are major challenges in the development of effective cancer therapeutics. Substantial literature on this subject highlights that populations consuming diets rich in fibers, fruits and vegetables have a significantly reduced incidence rate of CRC. This chemo-preventive effect is primarily associated with the presence of phytochemicals in the dietary components. Plant-derived chemical agents act as a prominent source of novel compounds for drug discovery. Phytochemicals have been the focus of an increasing number of studies due to their ability to modulate carcinogenic processes through the alteration of multiple cancer cell survival pathways. Despite promising results from experimental studies, only a limited number of phytochemicals have entered into clinical trials. The purpose of the current review is to compile previously published pre-clinical and clinical evidence of phytochemicals in cases of CRC. A PubMed, Google Scholar and Science Direct search was performed for relevant articles published between 2008–2018 using the following key terms: ‘Phytochemicals with colorectal cancers’, ‘apoptosis’, ‘cell cycle’, ‘reactive oxygen species’ and ‘clinical anticancer activities’. The present review may aid in identifying the most investigated phytochemicals in CRC cells, and due to the limited number of studies that make it from the laboratory bench to clinical trial stage, may provide a novel foundation for future research.

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Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect

Cited by 55 publications

References 73 publications

Quinoa Secondary Metabolites and Their Biological Activities or Functions

Quinoa Secondary Metabolites and Their Biological Activities or Functions

Alantolactone induces gastric cancer BGC‑823 cell apoptosis by regulating reactive oxygen species generation and the AKT signaling pathway

Potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer (Review)

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