Morinda citrifolia leaf enhanced performance by improving angiogenesis, mitochondrial biogenesis, antioxidant, anti-inflammatory &amp; stress responses

Shalan, Nor Aijratul Asikin Mohamad; Mustapha, Noordin Mohamed; Mohamed, Suhaila

doi:10.1016/j.foodchem.2016.05.179

Cited by 33 publications

(28 citation statements)

References 36 publications

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“…After 6‐week treatment, the MC leaf 50% ethanol extract almost quintupled the swimming time to exhaustion, compared with the control mice, demonstrating antifatigue or ergogenic properties that is better than green tea or ME extract. A previous study showed MC leaf water extract tripled mice swimming performance compared with the control mice after 4‐week consumption (Mohamad Shalan, Mustapha, & Mohamed, ). The MC400 mice could swim five times longer than the control mice, although they had similar blood glucose level to the control mice that were lower than the other treated mice after 30‐min swimming.…”

Section: Discussionmentioning

confidence: 91%

“…The results suggested that the extract delayed fatigue by progressively improving mitochondrial biogenesis, glycogen stores, fat and carbohydrate metabolism (PDK4; GLUT4), energy production rate and efficiency, electron transport, antioxidant status, and lactate removal. MC also reduced stress, inflammation, improved neuronal activities (dopamine, noradrenaline, serotonin, and cortisol), and angiogenesis (Mohamad Shalan et al, ). Green tea reportedly enhanced endurance by gradually amending molecular enzyme regulation and protein changes during exercise training (Murase, Haramizu, Shimotoyodome, Tokimitsu, & Hase, ).…”

Section: Discussionmentioning

confidence: 99%

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Standardized Morinda citrifolia L. and Morinda elliptica L. leaf extracts alleviated fatigue by improving glycogen storage and lipid/carbohydrate metabolism

Osman

Mohamed

2018

Phytotherapy Research

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The antifatigue properties of Morinda elliptica (ME) leaf were compared with Morinda citrifolia (MC) leaf extracts. Sixty Balb/C mice were administered (N = 10): control water, standardized green tea extract (positive control 200 mg/kg body weight [BW]), either 200 or 400 mg MC/kg BW, or either 200 or 400 mg ME/kg BW). The mice performances, biochemical, and mRNA expressions were evaluated. After 6 weeks, the weight-loaded swimming time to exhaustion in the mice consuming 400 mg MC/kg, were almost five times longer than the control mice. The gene expressions analysis suggested the extracts enhanced performance by improving lipid catabolism, carbohydrate metabolism, electron transport, antioxidant responses, energy production, and tissue glycogen stores. The MC and ME extracts enhanced stamina by reducing blood lactate and blood urea nitrogen levels, increasing liver and muscle glycogen reserve through augmenting the glucose metabolism (glucose transporter type 4 and pyruvate dehydrogenase kinase 4), lipid catabolism (acyl-Coenzyme A dehydrogenases and fatty acid translocase), antioxidant (superoxide dismutase 2) defence responses, electron transport (COX4I2), and energy production (PGC1α, NRF1, NRF2, cytochrome C electron transport, mitochondrial transcription factor A, UCP1, and UCP3) biomarkers. The MC (containing scopoletin and epicatechin) was better than ME (containing only scopoletin) or green tea (containing epicatechin and GT catechins) for alleviating fatigue.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Standardized Morinda citrifolia L. and Morinda elliptica L. leaf extracts alleviated fatigue by improving glycogen storage and lipid/carbohydrate metabolism

Osman

Mohamed

2018

Phytotherapy Research

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“…It was reported that the antioxidant activity of the compounds scopoleletin and epicatechin in the extract progressively extended the exhaust time three times more than the extract used as control. These results showed that the aqueous extract of noni plant leaves helped to slow fatigue, increasing energy production, and an excellent future acquisition in improving the physical and mental performance of athletes and women in the postmenopausal state (Shalan, Mustapha, & Mohamed, 2016).…”

Section: Antioxidant Activitymentioning

confidence: 83%

“…The antispasmodic ex vivo effect of NJ was also observed by up to 90% inhibition of calcium and cholinergic induced spasms in jejunum segments model. Antiinflammatory responses of noni leaves have also been proven by Shalan et al (2016), suggesting the ingestion of noni edible leaf extract as an ergogenic resource for physical activity and disease recovery.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Properties and Applications of Morinda citrifolia (Noni): A Review

Almeida

Oliveira

Hotza

2019

Comp Rev Food Sci Food Safe

114

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Morinda citrifolia commonly known as noni is a perennial plant originating in Southeast Asia, consumed over 2000 years. Due to its versatility of adaptation and use of the structures of the plant for different therapeutic purposes, noni attracted the attention of researchers from the pharmaceutical and food industry. Chemical and nutritional analyzes already performed in M. citrifolia reveal the existence of more than 200 phytochemical substances with bioactive properties such as acids, alcohols, phenols, saccharides, anthraquinones, carotenoids, esters, triterpenoids, flavonoids, glycosides, lactones, iridoids, ketones, lactones, lignans, nucleosides, triterpenides, sterols, and aromatic compounds. The high nutritional value of M. citrifolia may induce therapeutic effects, including antimicrobial and antioxidant properties. The main industrial products from this plant are beverages (juice drinks), powders (from dried fruits), oil (from seeds), and leaf powders. Biological and phytotherapeutic applications of M. citrifolia are promising, but more extensive studies are still required. Thus, this review aims to gather updated and comprehensive information on Morinda citrifolia, discussing its traditional use, biochemical, phytotherapics, and toxicological properties, as well as the recent advances in the processing and standardization of products derived from noni fruit.

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“…A recent study reported by Shalan et al [92] demonstrated that noni leaf extract possessed ergogenic effects, helping delay fatigue by enhancing energy production, regulation, and efficiency in female mice after a swimming endurance test. Noni extract enhanced performance by improving angiogenesis in skeletal muscle and liver (via vascular endothelial growth factor A, VEGFA), showing antioxidant (superoxide dismutase–SOD2 and glutathione-GSH) and anti-inflammatory (IL-4 and IL-10) properties, and ameliorating mitochondrial biogenesis (via AMP-activated protein kinase (AMPK), uncoupling protein-3 (UCP-3), peroxisome transcriptional proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1α), and nuclear respiratory factor-2 (NRF2)) and stress response (cortisol).…”

Section: Morinda Citrifolia Linn (Noni)mentioning

confidence: 99%

Morinda citrifolia Linn. (Noni) and Its Potential in Obesity-Related Metabolic Dysfunction

et al. 2017

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Cultural and economic shifts in the early 19th century led to the rapid development of companies that made good profits from technologically-produced commodities. In this way, some habits changed in society, such as the overconsumption of processed and micronutrient-poor foods and devices that gave rise to a sedentary lifestyle. These factors influenced host-microbiome interactions which, in turn, mediated the etiopathogenesis of “new-era” disorders and diseases, which are closely related, such as obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease, hypertension, and inflammatory bowel disease, which are characterized by chronic dysregulation of metabolic and immune processes. These pathological conditions require novel and effective therapeutic approaches. Morinda citrifolia (noni) is well known as a traditional healing plant due to its medicinal properties. Thus, many studies have been conducted to understand its bioactive compounds and their mechanisms of action. However, in obesity and obesity-related metabolic (dysfunction) syndrome, other studies are necessary to better elucidate noni’s mechanisms of action, mainly due to the complexity of the pathophysiology of obesity and its metabolic dysfunction. In this review, we summarize not only the clinical effects, but also important cell signaling pathways in in vivo and in vitro assays of potent bioactive compounds present in the noni plant which have been reported in studies of obesity and obesity-associated metabolic dysfunction.

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Morinda citrifolia leaf enhanced performance by improving angiogenesis, mitochondrial biogenesis, antioxidant, anti-inflammatory & stress responses

Cited by 33 publications

References 36 publications

Standardized Morinda citrifolia L. and Morinda elliptica L. leaf extracts alleviated fatigue by improving glycogen storage and lipid/carbohydrate metabolism

Standardized Morinda citrifolia L. and Morinda elliptica L. leaf extracts alleviated fatigue by improving glycogen storage and lipid/carbohydrate metabolism

Properties and Applications of Morinda citrifolia (Noni): A Review

Morinda citrifolia Linn. (Noni) and Its Potential in Obesity-Related Metabolic Dysfunction

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