Morinda citrifolia Linn. (Noni) fruit extract attenuates ethanol seeking behavior in mouse runway paradigm

Khan, Yasmin; Pandy, Vijayapandi

doi:10.35333/jrp.2020.218

Cited by 2 publications

(2 citation statements)

References 24 publications

(31 reference statements)

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“…Furthermore, M. citrifolia fruit has been proposed to possess antidopaminergic properties, potentially leading to anti-motivational effects against ethanol self-administration in mice. The phytochemicals rutin and scopoletin ( Figure 7 ) may be responsible for this effect and are currently being studied to further explore their potential against ethanol-seeking behavior in mouse models [ 67 ].…”

Section: Resultsmentioning

confidence: 99%

Hawaiian Plants with Beneficial Effects on Sleep, Anxiety, and Mood, etc.

Meesakul,

Shea,

Wong

et al. 2023

Pharmaceuticals

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Diverse chemical messengers are responsible for maintaining homeostasis in the human body, for example, hormones and neurotransmitters. Various Hawaiian plant species produce compounds that exert effects on these messengers and the systems of which they are a part. The main purpose of this review article is to evaluate the potential effects of Hawaiian plants on reducing pain and anxiety and improving sleep and mood. A comprehensive literature search was conducted in SciFinder, PubMed, Science Direct, Scopus, Google Scholar, and Scientific Information Database between 2019 and 2023 to identify related articles. Results indicate that several Hawaiian plant species, such as M. citrifolia and P. methysticum, have medicinal properties associated with these effects. These plants have been used in traditional Hawaiian cultural practices for centuries, suggesting their potential to benefit human health and well-being. This review presents a comprehensive analysis of the available evidence concerning the potential impacts of Hawaiian plants on sleep, anxiety, mood, and pain.

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Section: Resultsmentioning

confidence: 99%

Hawaiian Plants with Beneficial Effects on Sleep, Anxiety, and Mood, etc.

Meesakul,

Shea,

Wong

et al. 2023

Pharmaceuticals

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“…CPP is a method developed for the evaluation of addiction by experimental and clinical methods. However, it is widely used to study drug reward processes predominantly in rodents [21,22]. CPP is a learned behaviour founded on Pavlovian conditioning.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the pharmacological potential of myricetin on alcohol addiction in mice

Yunusoğlu¹,

SHAHZADI²,

Türel³

et al. 2022

jrp

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Alcohol addiction is one of the leading causes which is associated with morbidity and mortality with outcomes in high healthcare and economic costs. Myricetin is a flavonoid that demonstrates therapeutic actions in many central nervous system diseases. In the current study, the conditioned place preference (CPP) tests were performed to examine the effects of myricetin on ethanol reward. During conditioning, intraperitoneal (i.p) administration of ethanol (2 g/kg) and serum physiologic were given on alternate days for 8 days. In order to evaluate the effect of myricetin on the development of alcohol addiction, myricetin was injected into mice 30 minutes before ethanol administration. Subsequently, a daily myricetin injection was performed to evaluate the effect of myricetin on the extinction of alcohol addiction. Finally, ethanol was administered 900 seconds after different dose myricetin administration, and reinstatement was evaluated immediately thereafter. Systemic ethanol (2 g/kg, i.p) administration significantly produced CPP. Myricetin (5 and 10 mg/kg, i.p) attenuated the development of ethanol addiction (p < 0.05). Systemic myricetin injections immediately after each extinction period precipitated extinction and decreased reinstatement (10 mg/kg, i.p, p < 0.05, respectively). Ethanol alone and in combination with myricetin did not change locomotor activity and motor coordination. As a result, it can be suggested that myricetin is effective in attenuating the rewarding effect of alcohol in mice and can be used for the adjunctive therapy for alcohol addiction. In addition, it will be appropriate to conduct mechanistic experimental studies regarding these results in the future.

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Morinda citrifolia Linn. (Noni) fruit extract attenuates ethanol seeking behavior in mouse runway paradigm

Cited by 2 publications

References 24 publications

Hawaiian Plants with Beneficial Effects on Sleep, Anxiety, and Mood, etc.

Hawaiian Plants with Beneficial Effects on Sleep, Anxiety, and Mood, etc.

Investigation of the pharmacological potential of myricetin on alcohol addiction in mice

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