Morinda citrifolia (Noni) Juice Suppresses A549 Human Lung Cancer Cells via Inhibiting AKT/Nuclear Factor-κ B Signaling Pathway

Ma, Lingdi; Lin, Guibin; Yang, Lu-Bo; Cao, Jialin; Wang, Jian; Chen, Qiong-di; Li, Weiqiang; Zhong, Wang-Jing

doi:10.1007/s11655-020-3421-y

Cited by 14 publications

(11 citation statements)

References 29 publications

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“…proteins in in vitro condition, and in in vivo tumor tissue, it downregulated AKT/NF-KB signaling pathway. [49] Epidermal growth factor receptor, upon ligand binding, oligomerizes and phosphorylates, which leads to activation of downstream signaling pathways (MAPK, PI3K/Akt/mTOR, and JAK-STAT), resulting in the upregulation of antiapoptotic, angiogenic, and mitogenic genes. The overexpression of EGFR on cancer cells due to mutation can be utilized for the EGFR-targeted therapy.…”

Section: Discussionmentioning

confidence: 99%

Epoxyazadiradione induced apoptosis/anoikis in triple‐negative breast cancer cells, MDA‐MB‐231, by modulating diverse cellular effects

Lakshmi

Jalaja

Sasidhar

et al. 2021

J Biochem & Molecular Tox

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Triple-negative breast cancer (TNBC) is one of the most aggressive forms of its kind, which accounts for 15-20% of all breast cancers. As this cancer form lacks hormone receptors, targeted chemotherapy remains the best treatment option. Apoptosis and anoikis (detachment-induced cell death) induction by small molecules can prevent TNBC metastasis to a greater extent. Epoxyazadiradione (EAD) is a limonoid from the neem plant with an anticancer property. Here, we demonstrate that EAD induced mitochondria-mediated apoptosis and anoikis in TNBC cells (MDA-MB-231). Apart from this, it promotes antimigration, inhibition of colony formation, downregulation of MMP-9 and fibronectin, induction of G2/M phase arrest with downregulation of cyclin A2/cdk2, interference in cellular metabolism, and inhibition of nuclear factor kappa-B (NF-KB) nuclear translocation. Moreover, a significant reduction is observed in the expression of EGFR on the plasma membrane and nucleus upon treatment with EAD. Among the diverse cellular effects, anoikis induction, metabolic interference, and downregulation of membrane/nuclear EGFR expression by EAD are reported here for the first time. To summarize, EAD targets multiple cellular events to induce growth arrest in TNBC, and hence can be developed into the best antineoplastic agent in the future.

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Section: Discussionmentioning

confidence: 99%

Epoxyazadiradione induced apoptosis/anoikis in triple‐negative breast cancer cells, MDA‐MB‐231, by modulating diverse cellular effects

Lakshmi

Jalaja

Sasidhar

et al. 2021

J Biochem & Molecular Tox

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“…Liquid chromatograph‐mass spectrometer detection was referred to the previous literatures with appropriate adjustment based on the current study (Ma et al, 2020). Specifically, an Agilent 1290 Infinity II UHPLC system combined with an Agilent 6545 UHD and Accurate‐Mass Q‐TOF/MS was used for LC‐MS detection.…”

Section: Methodsmentioning

confidence: 99%

Deciphering the initial products of coal during methanogenic bioconversion: Based on an untargeted metabolomics approach

et al. 2021

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Although the process of microbial degradation of coal to produce biomethane has got much attention from many research works, the products profiles of coal at the initial stage of methanogenic bioconversion are not clear yet. In this study, five coal‐degrading bacterial strains (CD1, CD10, CD20, CD24, and CD25) from a methanogenic community were isolated and identified. Among them, CD1 and CD24 belong to Paenibacillus sp., CD10 and CD20 belong to Bacillus sp., and CD25 belongs to Stenotrophomonas sp. After biotreatment of lignite and bituminous coal, the kinds of newly produced compounds were 33 and 45, respectively. Metabolomics analysis showed that a large number of alkane compounds and heterocyclic aromatic compounds were produced after degradation of bituminous coal and lignite by isolated bacteria, and most of the compounds had been produced in a hydroxylated or acylated manner, indicating that the initial microbial treatment enhanced the bioavailability of coal. Some alkaloids and biosurfactants were also detected in the aforementioned products, such as glycerophosphocholine, proveratrol A, proveratrol B, surfactin, etc. These microbial metabolites may play an important role in solubilization during the degradation of coal. This study added to the understanding of the complicated metabolic process of methanogenic coal bioconversion and enabled effective production of biomethane with appropriate metabolic strategies.

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“…Pooled estimates from 3 studies [27][28][29] showed that noni administration significantly reduced experimental lung cancer tumor volume compared to overall control (SMD −1.31, 95% CI −2.50-−0.13) (Figure 3). Subgroup analysis revealed significant effects of noni administration in reducing tumor volume when compared to negative controls that is, saline or vehicle (SMD −2.70, 95% CI −3.50-−1.90) but no significant difference when compared to other treatments including oxaliplatin and erlotinib (SMD −0.39, 95% CI −2.11-1.33).…”

Section: Experimental Lung Cancermentioning

confidence: 99%

Efficacy and Safety of Morinda citrifolia L. (Noni) as a Potential Anticancer Agent

et al. 2022

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Cancer is a major cause of morbidity and mortality worldwide and therefore there has been interest in discovering the phytoconstituents of medicinal plants exhibiting anticancer activities. Morinda citrifolia L., commonly known as Noni, has shown anticancer properties in in vitro, in vivo, and in clinical studies. A systematic review was conducted to collate scientific evidence on the anticancer properties of M. citrifolia using pre-determined keywords on 5 electronic databases: MEDLINE, CENTRAL, LILACS, Web of Science, and EBSCOHost. A total of 51 clinical and preclinical studies comprising 41 efficacy and 10 safety studies were included in this review. Our findings showed that M. citrifolia demonstrated various anticancer properties in different cancer models, via multiple mechanisms including antitumor, antiproliferative, pro-apoptotic, antiangiogenesis, antimigratory, anti-inflammatory, and immunomodulatory activities. M. citrifolia is deemed to be a potentially valuable medicinal plant in the treatment of cancer through its many intrinsic pathways. More well-designed and reported preclinical efficacy and safety studies are needed to allow for better translation into future clinical studies which could further substantiate the role of M. citriflolia in cancer treatment.

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Morinda citrifolia (Noni) Juice Suppresses A549 Human Lung Cancer Cells via Inhibiting AKT/Nuclear Factor-κ B Signaling Pathway

Cited by 14 publications

References 29 publications

Epoxyazadiradione induced apoptosis/anoikis in triple‐negative breast cancer cells, MDA‐MB‐231, by modulating diverse cellular effects

Epoxyazadiradione induced apoptosis/anoikis in triple‐negative breast cancer cells, MDA‐MB‐231, by modulating diverse cellular effects

Deciphering the initial products of coal during methanogenic bioconversion: Based on an untargeted metabolomics approach

Efficacy and Safety of Morinda citrifolia L. (Noni) as a Potential Anticancer Agent

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