Moringa oleifera ethanolic extract attenuates tilmicosin-induced renal damage in male rats via suppression of oxidative stress, inflammatory injury, and intermediate filament proteins mRNA expression

Abou‐Zeid, Shimaa M.; Ahmed, Amany I.; Awad, Ashraf; Mohammed, Wafaa; Metwally, Mohamed M.M.; Almeer, Rafa; Abdel-Daim, Mohamed M.; Khalil, Samah R.

doi:10.1016/j.biopha.2020.110997

Cited by 31 publications

(16 citation statements)

References 81 publications

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“…Additionally, IL-10 and IκB-α were upregulated in a dose-dependent manner after MO flower hydroethanolic extracts were administered in macrophage cells stimulated with lipopolysaccharides ( Tan et al, 2015 ). Following treatment with MO in a diabetes rat model or chemically-induced liver and kidney damage, MO was found to provide its therapeutic effect by reducing the expressions of several pro-inflammatory cytokines TNFα, IL-1β, IL-6, and IL-12 ( Joung et al, 2017 ; Azevedo Í et al, 2018 ; Abdou et al, 2019 ; Chin et al, 2019 ; Abdel Fattah et al, 2020 ; Abd-Elhakim et al, 2021 ; Abou-Zeid et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Moringa Oleifera Lam. in Cardiometabolic Disorders: A Systematic Review of Recent Studies and Possible Mechanism of Actions

2022

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Cardiometabolic disorders (CMD) have become a global emergency and increasing burden on health and economic problems. Due to the increasing need for new drugs for cardiometabolic diseases, many alternative medicines from plants have been considered and studied. Moringa oleifera Lam. (MO), one of the native plants from several Asian countries, has been used empirically by people for various kinds of illnesses. In the present systematic review, we aimed to investigate the recent studies of MO in CMD and its possible mechanism of action. We systematically searched from three databases and summarized the data. This review includes a total of 108 papers in nonclinical studies and clinical trials of MO in cardiometabolic-related disorders. Moringa oleifera, extracts or isolated compound, exerts its effect on CMD through its antioxidative, anti-inflammatory actions resulting in the modulation in glucose and lipid metabolism and the preservation of target organ damage. Several studies supported the beneficial effect of MO in regulating the gut microbiome, which generates the diversity of gut microbiota and reduces the number of harmful bacteria in the caecum. Molecular actions that have been studied include the suppression of NF-kB translocation, upregulation of the Nrf2/Keap1 pathway, stimulation of total antioxidant capacity by reducing PKCζ activation, and inhibiting the Nox4 protein expression and several other proposed mechanisms. The present review found substantial evidence supporting the potential benefits of Moringa oleifera in cardiovascular or metabolic disorders.

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Section: Resultsmentioning

confidence: 99%

Moringa Oleifera Lam. in Cardiometabolic Disorders: A Systematic Review of Recent Studies and Possible Mechanism of Actions

2022

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“…Leaf extract of M. oleifera inhibits inflammatory cytokines production and regulates the inflammation by inhibiting NF-kB [25]. It was also observed that inflammation in Tilmicosin (Til) induced rats was reduced by M. oleifera extracts [39]. M. oleifera leaf extract protects against interstitial kidney inflammation with fibrosis by down-regulating KIM-1 in TiO 2 NPs induced male albino rats [41].…”

Section: Inflammationmentioning

confidence: 98%

Prospects for Protective Potential of Moringa oleifera against Kidney Diseases

Akter¹,

Rahman²,

Moni³

et al. 2021

Plants

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Kidney diseases are regarded as one of the major public health issues in the world. The objectives of this study were: (i) to investigate the causative factors involved in kidney disease and the therapeutic aspects of Moringa oleifera, as well as (ii) the effectiveness of M. oleifera in the anti-inflammation and antioxidant processes of the kidney while minimizing all potential side effects. In addition, we proposed a hypothesis to improve M. oleifera based drug development. This study was updated by searching the key words M. oleifera on kidney diseases and M. oleifera on oxidative stress, inflammation, and fibrosis in online research databases such as PubMed and Google Scholar. The following validation checking and scrutiny analysis of the recently published articles were used to explore this study. The recent existing research has found that M. oleifera has a plethora of health benefits. Individual medicinal properties of M. oleifera leaf extract, seed powder, stem extract, and the whole extract (ethanol/methanol) can up-increase the activity of antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH), while decreasing the activity of inflammatory cytokines such as TNF-α, IL-1β, IL-6, and COX-2. In our study, we have investigated the properties of this plant against kidney diseases based on existing knowledge with an updated review of literature. Considering the effectiveness of M. oleifera, this study would be useful for further research into the pharmacological potential and therapeutic insights of M. oleifera, as well as prospects of Moringa-based effective medicine development for human benefits.

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“…Specificity � the cases of negative diagnostic results detected by color Doppler ultrasound/the cases of actual negative results detected by color Doppler ultrasound × 100%; sensitivity � the cases of positive diagnostic results detected by color Doppler ultrasound/the cases of actual positive results detected by color Doppler ultrasound × 100%; detection accuracy � the cases of both positive and negative results detected by color Doppler ultrasound and pathological diagnosis/the total number of patients × 100% [13][14][15].…”

Section: Observation Indexesmentioning

confidence: 99%

Diagnostic Value of Color Doppler Ultrasound Combined with Superb Microvascular Imaging in the Detection of Small Renal Tumors Less than 3 cm Treated with Jinkui Shenqi Pills

Gong

2021

Evidence-Based Complementary and Alternative Medicine

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The purpose of this study was to investigate the diagnostic value of color Doppler ultrasound combined with superb microvascular imaging (SMI) in the detection of small renal tumors less than 3 cm treated with Jinkui Shenqi pills. 50 cases were randomly selected from the patients with angioleiomyoma (a kind of small renal tumor) less than 3 cm confirmed by pathological examination and treated in our hospital from January 2018 to January 2020. All patients were treated with Jinkui Shenqi pills. All patients were first detected by color Doppler ultrasound and then by SMI. The results of color Doppler ultrasound were used as the control group, while those of color Doppler ultrasound combined with SMI were used as the experimental group. After that, the specificity, sensitivity, positive and negative detection results, and detection accuracy were compared between the two groups. The specificity and sensitivity in the experimental group were significantly higher than those in the control group, with statistical significance ( P < 0.05 ). The cases of positive and negative detection results in the experimental group were significantly higher than those in the control group, with statistical significance ( P < 0.05 ). The detection accuracy in the experimental group was significantly higher than that in the control group, with statistical significance ( P < 0.05 ). The specificity, sensitivity, positive and negative detection results, and detection accuracy of color Doppler ultrasound combined with SMI in the detection of small renal tumors less than 3 cm treated with Jinkui Shenqi pills were all significantly higher than those of color Doppler ultrasound; therefore, the application of color Doppler ultrasound combined with SMI for the diagnosis of small renal tumors is of high value.

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Moringa oleifera ethanolic extract attenuates tilmicosin-induced renal damage in male rats via suppression of oxidative stress, inflammatory injury, and intermediate filament proteins mRNA expression

Cited by 31 publications

References 81 publications

Moringa Oleifera Lam. in Cardiometabolic Disorders: A Systematic Review of Recent Studies and Possible Mechanism of Actions

Moringa Oleifera Lam. in Cardiometabolic Disorders: A Systematic Review of Recent Studies and Possible Mechanism of Actions

Prospects for Protective Potential of Moringa oleifera against Kidney Diseases

Diagnostic Value of Color Doppler Ultrasound Combined with Superb Microvascular Imaging in the Detection of Small Renal Tumors Less than 3 cm Treated with Jinkui Shenqi Pills

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