Moringa oleifera Leaf Extract: Beneficial Effects on Cadmium Induced Toxicities - A Review

Mallya, Roopashree; Chatterjee, Pratik Kumar; Vinodini, N A; Chatterjee, Poulomi; Mithra, Prasanna

doi:10.7860/jcdr/2017/21796.9671

Cited by 20 publications

(20 citation statements)

References 26 publications

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“…Cadmium exposure is known to affect lipid metabolism even at low concentrations [ 39 – 41 ] and to cause a dose dependent increase in plasma triglyceride levels [ 42 ]. Using Oil-Red-O staining, which is able to dye neutral triglycerides and glycolipids, we found that cadmium induced lipid droplet accumulation that was not observed when cells were co-treated with OLE and cadmium ( Fig 8A ).…”

Section: Resultsmentioning

confidence: 99%

Green olive leaf extract (OLE) provides cytoprotection in renal cells exposed to low doses of cadmium

et al. 2019

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Cadmium (Cd) is a heavy and highly toxic metal that contaminates air, food and water. Cadmium accumulates in several organs altering normal functions. The kidney is the major organ at risk of damage from chronic exposure to cadmium as a contaminant in food and water. This study aims to investigate the beneficial effects of OLE in renal collecting duct MCD4 cells exposed to a low dose cadmium (1 μM). In MCD4 cells cadmium caused an increase in ROS production, as well as generation of lipid droplets and reduced cell viability. Moreover, cadmium exposure led to a remarkable increase in the frequency of micronuclei and DNA double-strand breaks, assessed using the alkaline comet assay. In addition, cadmium dramatically altered cell cytoskeleton architecture and caused S-glutathionylation of actin. Notably, all cadmium-induced cellular deregulations were prevented by co-treatment with OLE, possibly due to its antioxidant action and to the presence of bioactive phytocompounds. Indeed, OLE treatment attenuated Cd-induced actin S-glutathionylation, thereby stabilizing actin filaments. Taken together, these observations provide a novel insight into the biological action of OLE in renal cells and support the notion that OLE may serve as a potential adjuvant against cadmium-induced nephrotoxicity.

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Section: Resultsmentioning

confidence: 99%

Green olive leaf extract (OLE) provides cytoprotection in renal cells exposed to low doses of cadmium

et al. 2019

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“…8 The bioavailability, retention and toxicity of this environmental dangerous metal are affected by many factors, nutritional status such as low iron levels in the body. 9 Hematology, the Science of blood, forms a crucial principle of various diagnostic procedures as it includes the examination of formed elements of the circulatory system. 10 Experimental evidences have shown that blood is one of the vital tissues having reproducible metabolic changes.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Moringa oleifea Extract in Attenuating the Toxic Effect on Platelet Count: An Experiment on Cadmium Exposed Rats

Chatterjee

Kunal

et al. 2019

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Aims and Objective:To determine the role of Moringa oleifera on total platelet count alterations (T-PC) in rats treated with cadmium. Materials and Methods: In the present study female adult Wistar Albino rats, (180-200) gm were divided into, Group I-normal control, Group II-pretreated control, group III-cadmium treated , group IV-pre-treated with Moringa oleifera leaf extract (MOE) and then administered oral cadmium for a day, with n=6 each RESULTS : Indicate that the pre-treatment with MOE (100 mg/kg/bw) prior to cadmium infusion augmented the level of total platelet count (p≤0.001) as compared to the cadmium-exposed group, which might have a role in clotting mechanisms also. Conclusion: Moringa oleifera extract has a beneficial effect on platelet count in cadmium-induced animal model.

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“…Moringa may have induced the repairing effect on the damaged liver by its essential amino acid such as metionine and cysteine boosting the total protein contents as evidenced by several authors [53,54]. Some authors reported that among whole plant of Moringa oleifera leaves are responsible for the greater production of antioxidants and have the capacity to act as a protective shield during oxidative damage [55][56][57]. Our previous work on MLE against bio-pesticide also showed a decrease percent death rate in zebra fishes [25].…”

Section: Discussionmentioning

confidence: 99%

Imidacloprid Toxicity and Its Attenuation by Aqueous Extract of Moringa Oleifera Leaf in Zebra Fish, Danio Rerio

Yadav

Ahmad

Zahra

2020

Int J Curr Pharm Sci

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Objective: Imidacloprid (IMC) is a systemic chloro-nicotinyl insecticide that is applied in crop fields to control a wide variety of harmful insects and pests. The objective of the present study was to evaluate the mitigating effects of Moringa leaf extract (MLE) against Imidacloprid (IMC) induced mortality after acute toxicity bioassay in zebrafish, Danio rerio. Methods: The fishes were exposed to various concentrations of IMC to estimate the LC50 values at different exposure periods using the probit analysis. To assess the attenuating effect on mortality fishes were exposed to different concentrations of MLE along with 24 and 96 h LC50 of IMC. Mortality rate of fishes was recorded during all experimental periods. Results: The LC50 values were found to be 0.423, 0.352, 0.297 and 0.270 ml/l after 24, 48, 72 and 96 h respectively. The upper confidence limits were 0.491, 0.408, 0.334 and 0.302 ml/l and lower confidence limits were 0.355, 0.296, 0.260 and 0.238 ml/l for 24, 48, 72 and 96 h respectively. The fishes remain alive at 12 ml/l and 10 ml/l of MLE against 24 and 96 h LC50 respectively. Some behavioral responses such as violent, sluggish and erratic movement, respiratory distress, mucous secretion all over the body, discoloration were also observed in IMC treated fishes in comparison to MLE treated fishes. Conclusion: These findings demonstrated that MLE has mitigating effects against the toxic influence of IMC on mortality in zebra fishes which is attributed to its antioxidant effects.

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Moringa oleifera Leaf Extract: Beneficial Effects on Cadmium Induced Toxicities - A Review

Cited by 20 publications

References 26 publications

Green olive leaf extract (OLE) provides cytoprotection in renal cells exposed to low doses of cadmium

Green olive leaf extract (OLE) provides cytoprotection in renal cells exposed to low doses of cadmium

Effectiveness of Moringa oleifea Extract in Attenuating the Toxic Effect on Platelet Count: An Experiment on Cadmium Exposed Rats

Imidacloprid Toxicity and Its Attenuation by Aqueous Extract of Moringa Oleifera Leaf in Zebra Fish, Danio Rerio

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