Morning glory disc anomaly and ipsilateral sporadic optic pathway glioma

Abstract

PurposeTo present a rare case of morning glory disc anomaly in association with an ipsilateral low grade glioma.ObservationsA 5 year old male presented with a unilateral morning glory disc anomaly and an ipsilateral sporadic optic pathway glioma with chiasmal involvement. After a strict patching regimen his vision improved from 20/400 to 20/80.Conclusions and importanceThis report strengthens the recommendation for brain magnetic resonance imaging in patients with morning glory disc anomaly. Patching of the contralateral eye should be attempted since the role of amblyopia may be significant.

Unilateral morning glory disc anomaly in a patient with prenatal Zika virus exposure

“…Complex retinal detachments and choroidal neovascularization may develop in eyes with MGDA [4,19]. Systemic cerebral and craniofacial malformations may be present including frontonasal dysplasia, basal encephalocele, pituitary insufficiency, agenesis of the corpus callosum, hypertelorism, cleft lip, cleft palate, and cerebrovascular anomalies [1,2,6,19]. Therefore, neuroimaging should be performed in all cases.…”

“…MGDA is a non-progressive congenital anomaly of the optic disc that has been associated with other ocular anomalies including strabismus, microphthalmia, amblyopia, leukocoria, nystagmus, eyelid hemangioma, and visual field defects [ 1 , 2 , 4 – 7 , 19 ]. Complex retinal detachments and choroidal neovascularization may develop in eyes with MGDA [ 4 , 19 ].…”

“…Morning glory disc anomaly (MGDA) is a rare congenital anomaly of the optic disc and peripapillary retina [1,2]. The prevalence of MGDA has been estimated to be approximately 2.6/100,000 [3].…”

“…The prevalence of MGDA has been estimated to be approximately 2.6/100,000 [ 3 ]. Characteristic findings include an enlarged optic disc with a central funnel-shaped excavation, a hypopigmented central tuft of glial tissue, peripapillary chorioretinal atrophy, and radial spoke-like vascular pattern [ 1 , 2 , 4 , 5 ]. MGDA is sporadic, exhibits female predominance, and is typically unilateral [ 1 , 4 , 6 , 7 ].…”

Magnetic Resonance Imaging in the evaluation of Vasculopathy in the Morning Glory Anomaly.

“…The fundoscopic evaluation demonstrates radially oriented thin vessels emanating toward the periphery of the retina [1]. Enlargement of the ipsilateral optic nerve can be present; this may represent as an optic pathway tumor reminiscent of neuro bromatosis, type 1 [4]. Furthermore, it is associated with numerous central nervous system anomalies,…”