Morning glory disc anomaly and facial hemangiomas in a girl with moyamoya syndrome

Sathyan, Sanitha; Chackochan, Mariea

doi:10.4103/ijo.ijo_538_18

Cited by 9 publications

(8 citation statements)

References 7 publications

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“…Over the past 25 years, several case reports and case series have reported the co-existence of MMD and MGDA. [ 9 10 11 12 13 14 15 ] The aforementioned association has initially described by Hanson et al . [ 16 ] back in 1985, while many additional cases have been reported since.…”

Section: Discussionmentioning

confidence: 99%

Internal carotid artery origin of the anterior cerebral artery: A rare anatomic intracranial arterial variation in a child with morning glory disc anomaly and moyamoya vascular pattern; case report and review of literature

et al. 2020

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Morning glory disc anomaly (MGDA) characterizes a congenital dysgenetic disorder of the optic disc, coexisting with arterial intracranial abnormalities, including Moyamoya vascular disease, a significantly rare disease in the European populations. We report a 2.5-year-old female child from Greece previously diagnosed with MGDA, who presented with right-hand paresis, accompanied by focal epileptic spasms, followed by an episode of brief absence seizure, as well as some arm clonic spasms. Magnetic resonance angiography scan revealed the presence of an anomalous origin of the anterior cerebral artery (ACA) from the internal carotid artery (ICA) along with vascular abnormalities, compatible with Moyamoya pattern. To the very best of our knowledge, this is the first reported case of anomalous origin of ACA from the supraclinoid ICA accompanied by severe occlusive intracranial disease (moyamoya-like pattern) in a patient with known MGDA, highlighting the embryonic character of the vascular manifestations in MGDA. It also verifies the association of Moyamoya pattern with MGDA, thus linking vascular dysgenesis as a possible cause of MGDA.

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Section: Discussionmentioning

confidence: 99%

Internal carotid artery origin of the anterior cerebral artery: A rare anatomic intracranial arterial variation in a child with morning glory disc anomaly and moyamoya vascular pattern; case report and review of literature

et al. 2020

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“…Several cases of facial hemangiomas in association with MA and morning glory disc anomaly (MGDA) have been described. MGDA is a congenital condition characterized by an abnormal optic disc with whitish glial tissue at the center and radial blood vessels emerging from the rim of the disc [51]. An embryonic origin, mainly mesectodermal dysgenesis, has been postulated as the culprit of extensive capillary hemangiomas seen in association with MGDA [52].…”

Section: Methodsmentioning

confidence: 99%

Cutaneous manifestations in Moyamoya angiopathy: A review

Mitri

Bersano

Hervé

et al. 2021

Euro J of Neurology

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Background and purpose: Moyamoya angiopathy (MA) is a progressive cerebrovascular disease with a poorly understood pathophysiology. It is mainly characterized by progressive bilateral stenosis of the terminal intracranial part of the supraclinoid internal carotid arteries and the proximal parts of the middle and anterior cerebral arteries. This results in early‐onset ischemic or hemorrhagic strokes. The disease may be idiopathic (known as Moyamoya disease) or associated with other heritable or acquired conditions, including type 1 neurofibromatosis or other RASopathies, sickle cell disease, Down syndrome, or autoimmune disorders (known as Moyamoya syndrome). Apart from the brain, other organ manifestations including cutaneous ones have also been described in MA patients. Materials and methods: A literature research on PubMed was performed for articles mentioning the cutaneous association in MA and published between 1994 and October 2020. Conclusion: The present review summarizes the cutaneous associations as well as the coincidental dermatological findings seen in MA patients. Those include changes in the epidermis, dermis, or skin appendages for example café‐au‐lait spots, hypomelanosis of Ito, livedo racemosa, hemangiomas, premature graying of hair, chilblains etc.

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“…We identified 13 articles of MMD-associated MGDA, including 11 case reports, 1 ophthalmic image report, and 1 retrospective study (5,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). The retrospective study evaluated intracranial vascular anomalies in 20 patients with MGDA and diagnosed four of them with MMD (9).…”

Section: And Various Ophthalmic Findings Morning Glory Disc Anomalymentioning

confidence: 99%

“…However, several cases of morning glory disc anomaly (MGDA) have been reported in pediatric MMD patients. The typical intracranial vascular and retinovascular anomalies suggest that there may be a common denominator between these two diseases (5). Central retinal artery occlusion, amaurosis fugax, and ocular ischemic syndrome were also reported in patients with MMD (6).…”

Section: Introductionmentioning

confidence: 99%

Moyamoya Disease Associated With Morning Glory Disc Anomaly and Other Ophthalmic Findings: A Mini-Review

et al. 2020

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Moyamoya disease (MMD) is a chronic cerebrovascular disease that frequently results in intracranial ischemia or hemorrhage. Its concurrence with varying ophthalmic findings is relatively rare yet may lead to irreversible blindness. We performed a search and review of the literature to characterize the relevance of MMD (excluding moyamoya syndrome) and ophthalmic findings. As a result, a total of 38 articles identified from PubMed and Web of Science were included in this mini-review. Patients with MMD sometimes present with decreased visual acuity or visual field defects before the onset of symptomatic cerebrovascular dysfunction. The most predominant ophthalmic condition in MMD patients is the morning glory disc anomaly (MGDA). Deficiency during neuroectodermal genesis and subsequent mesodermal changes may be responsible for the association between these two diseases. Thus, it may be beneficial for patients with MGDA to receive cerebral vascular examinations as the precaution against life-threatening intracranial angiopathy. Other ophthalmic findings reported in cases of MMD include retinal vascular occlusion, optic disc pallor, cortical blindness, etc. For most of the patients with MMD, retinal examinations would be recommended to prevent potential loss of vision. It is essential for both neurologists and ophthalmologists to be aware of the correlation between cerebrovascular diseases such as MMD and ocular manifestations to achieve a comprehensive diagnosis.

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Morning glory disc anomaly and facial hemangiomas in a girl with moyamoya syndrome

Cited by 9 publications

References 7 publications

Internal carotid artery origin of the anterior cerebral artery: A rare anatomic intracranial arterial variation in a child with morning glory disc anomaly and moyamoya vascular pattern; case report and review of literature

Internal carotid artery origin of the anterior cerebral artery: A rare anatomic intracranial arterial variation in a child with morning glory disc anomaly and moyamoya vascular pattern; case report and review of literature

Cutaneous manifestations in Moyamoya angiopathy: A review

Moyamoya Disease Associated With Morning Glory Disc Anomaly and Other Ophthalmic Findings: A Mini-Review

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