Morning glory disk anomaly—more than meets the eye

Traboulsi, Elias I.

doi:10.1016/j.jaapos.2009.05.015

Cited by 10 publications

(9 citation statements)

References 18 publications

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“…2,3,13 Also, muscular cells have been reported as part of the normal choroid and sclera 14 and as heterotopic elements in abnormally developed eyeballs too. 12 This theory reinforces the hypothesis that enlargement of the optic nerve and chiasm could be most likely malformation, due to the presence of dysplastic tissue, and nonneoplastic in nature.…”

Section: Discussionsupporting

confidence: 82%

“…The exact pathogenesis of MGDA is still unknown, but some MR and histopathologic studies which described bulbar defect characteristics and the presence of abnormal tissue localized along the ipsilateral optic pathway suggested a combined defect of ectodermal and mesodermal dysgenesis. 1,12 Besides the failure of fusion of the posterior sclera, disorganized spindle cells resembling those of embryonic mesenchyma has been described at its outer surface, 13 and glial and fatty aggregates have been recognized along the intraorbital optic nerve within the distal sheath as well as far from the optic disc. 2,3,13 Also, muscular cells have been reported as part of the normal choroid and sclera 14 and as heterotopic elements in abnormally developed eyeballs too.…”

Section: Discussionmentioning

confidence: 99%

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Morning Glory Disc Anomaly Associated with Ipsilateral Optic Nerve and Chiasm Thickening: Three Cases and Review of the Literature

et al. 2017

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Several extraorbital findings have been described in morning glory disc anomaly (MGDA), including optic pathway abnormalities. We want to emphasize the importance of looking for ipsilateral optic nerve and chiasm thickening in MGDA-affected patients because we think that it may be a relevant common associated finding to date not stressed by anyone. We report three cases of clinically diagnosed unilateral MGDA in which magnetic resonance imaging revealed enlargement of the ipsilateral optic nerve and chiasm. A literature analysis was made and previously reported MGDA cases, and case series were checked, looking for described, or misunderstood similar magnetic resonance imaging findings. Three other cases with very similar prechiasmatic optic nerve and chiasm findings were identified from the literature. Two further cases are discussed as possibly characterized by similar misinterpreted magnetic resonance features. Our study broadens the constellation of intra- and extraorbital findings of MGDA. Though magnetic resonance imaging is not sufficient to determine the neuropathological substrate of this finding, clinicians and radiologists should be aware of the possible association of MGDA with ipsilateral thickening of the optic nerve and chiasm, to properly plan the clinical and imaging follow-up. © 2017 Georg Thieme Verlag KG Stuttgart.New York

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Morning Glory Disc Anomaly Associated with Ipsilateral Optic Nerve and Chiasm Thickening: Three Cases and Review of the Literature

et al. 2017

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“…Descriptions of ocular anomalies associated with MGS are numerous, such as ciliary body cyst, aniridia, lens coloboma, strabismus, congenital cataract, nystagmus, eyelid hemangioma, lenticonus, and microphthalmia [5,28-31]. There have been also case reports of miscellaneous associations with MGS, such as hypertelorism, cleft lip and palate, renal anomalies, corpus callosum agenesis, and encephaloceles [22,26].…”

Section: Discussionmentioning

confidence: 99%

Unilateral morning glory optic disc anomaly in a case with Down syndrome

Altun

Kurna

et al. 2014

BMC Ophthalmol

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BackgroundThis case is unique because it is the first reported case of Down syndrome with morning glory optic disc anomaly in literature.Case presentationA 15-year-old girl with features of Down syndrome presented to the Clinic of Ophthalmology for a regular ophthalmologic examination. Her best corrected visual acuity was 20/50 in the right eye and 20/20 in the left eye. The fundus examination revealed findings compatible with unilateral morning glory optic disc anomaly in the right eye. The patient underwent a complete ophthalmologic and systemic evaluation to explore possible associated findings.ConclusionThis case report emphasizes the importance of ophthalmic screening-examinations in Down children to rule out any vision relevant pathology.

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“…16 Identification of MGDA at imaging should prompt a search for associated intracranial abnormalities, including midline craniofacial and skull base defects, vascular abnormalities, and cerebral malformations. 19,20 In particular, brain MR imaging and internal carotid artery MRA should be performed because of an association with transphenoidal basal encephalocele and congenital stenoocclusive change of the internal carotid arteries (moyamoya disease) in these patients. 20 MGDA can also be seen in association with PHACES (posterior fossa anomalies, hemangioma, arterial and aortic arch anomalies, cardiac anomalies, eye anomalies, and sternal anomalies and/or supraumbilical raphe).…”

Section: Morning Glory Disc Anomalymentioning

confidence: 99%