Morning glory disk anomaly with ipsilateral capillary hemangioma, agenesis of the internal carotid artery, and Horner syndrome: A variant of PHACES syndrome?

Puvanachandra, Narman; Heran, Manraj K. S.; Lyons, Christopher J.

doi:10.1016/j.jaapos.2008.04.005

Cited by 22 publications

(17 citation statements)

References 13 publications

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“…There has been at least 1 report suggesting that the coexistence of hemangioma, MGDA, and intracranial vascular abnormalities may reflect a manifestation of PHACES association. 31 MGDA has also been associated with skull base abnormalities, including basal cephaloceles. 1,13 It has been proposed that the incomplete fusion of the palates abrogates normal development of the optic nerves, potentially by drawing them into the defect.…”

Section: Figmentioning

confidence: 99%

Morning Glory Disc Anomaly: Characteristic MR Imaging Findings

Ellika¹,

Robson²,

Heidary

et al. 2013

AJNR Am J Neuroradiol

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SUMMARY:Establishing the diagnosis of morning glory disc anomaly is crucial to appropriate patient treatment. Although typically made clinically, the diagnosis is not always straightforward, especially in circumstances where physical examination is limited. The goal of this study was to define the spectrum and frequency of orbital findings in a series of patients with funduscopically-confirmed morning glory disc anomaly by using MR imaging. MR imaging demonstrated 3 findings in all patients: 1) funnel-shaped morphologic pattern of the posterior optic disc with elevation of the adjacent retinal surface; 2) abnormal tissue associated with the distal intraorbital segment of the ipsilateral optic nerve, with effacement of the regional subarachnoid spaces; and 3) discontinuity of the uveoscleral coat. These findings were not observed in any of the unaffected globes of the study patients. In summary, these consistent and characteristic findings of morning glory disc anomaly should allow for accurate differentiation from other ocular anomalies and have the potential to guide appropriate management of this patient population. ABBREVIATIONS:MGDA ϭ morning glory disc anomaly

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Section: Figmentioning

confidence: 99%

Morning Glory Disc Anomaly: Characteristic MR Imaging Findings

Ellika¹,

Robson²,

Heidary

et al. 2013

AJNR Am J Neuroradiol

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“…In pediatric patients with clinical entities of morning glory disk anomaly, ipsilateral capillary hemangioma, and Horner syndrome, agenesis of the internal carotid artery (a variant of PHACES syndrome) should be considered and neuroimaging should be ordered. 5 Another report on the pathology of the internal carotid artery in a pediatric population concluded the ICA bifurcation to be the most common site of intracranial aneurysm; as such, various theories were proposed for the formation of aneurisms, including defects in medial or internal elastic membrane as a result of congenital anomaly, a connective tissue disorder, infective process, and/or head injuries. 6 Our case is unique in that acquired infantile Horner syndrome has not previously been linked with spontaneous ICA dissection in infants and children without a history of trauma.…”

Section: Discussionmentioning

confidence: 99%

Acquired infantile Horner syndrome and spontaneous internal carotid artery dissection: A case report and review of literature

Pirouzian

Holz

et al. 2010

Journal of American Association for Pediatric Ophthalmology and

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“…20 MGDA can also be seen in association with PHACES (posterior fossa anomalies, hemangioma, arterial and aortic arch anomalies, cardiac anomalies, eye anomalies, and sternal anomalies and/or supraumbilical raphe). 21 …”

Section: Morning Glory Disc Anomalymentioning

confidence: 99%

“…Orbital hemangioma can be associated with other anomalies as a manifestation of PHACES association. 21 Most hemangiomas are treated conservatively anticipating involution. However, tumors that compromise vision can be treated with systemic propranolol.…”

Section: Orbital Neoplasmsmentioning

confidence: 99%