Morning glory seed keeps laxative effect while retains less subchronic toxicity after being fried

Ren, Shumeng; Zhang, Wei; Xu, Xia-jing; Zhou, Ye; Guo, Jingyan; Zhang, Xiaoli; Wang, Dongmei; Pan, Yingni; Liu, Xiaoqiu

doi:10.1016/j.jep.2019.112522

Cited by 2 publications

(1 citation statement)

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“…Pharbitidis Semen, the seeds of Pharbitis nil (L.) Choisy has been used as a purgative in Japan, China and Korea [ 2 , 3 ]. It has also been reported for having laxative properties in both rats and mice [ 4 ]. The first chemical investigation by Asahina in 1919 reported that alkaline hydrolysis of the crude resin glycoside named pharbitin gave three component organic acids and one glycosidic acid named pharbitic acid [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Different effects on the tonus of colon and ileum isolated from mouse by resin glycoside (pharbitin) of Pharbitidis Semen

Zhou

Tokutomi

Satou

et al. 2022

BMC Complement Med Ther

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Background Pharbitidis Semen (the seeds of Pharbitis nil), traditionally used as a purgative in Japan, China and Korea, contains a resin glycoside fraction named pharbitin, which is known as a purgative ingredient. Due to the complex nature of pharbitin, little is known about either the action on intestinal tension caused by resin glycoside itself or by its components. Methods In this study, we investigated the effects of pharbitin, the glycosidic acid fraction (pharbitic acid) and the aglycone fraction (phar-genin) generated from pharbitin on peristalsis of colon and ileum isolated from mice with the Magnus method. Results We demonstrated that pharbitin (3–30 μg/mL) concentration-dependently increased tonus of mice colon via acetylcholine receptors, its components phar-genin (1.27–12.7 μg/mL) and pharbitic acid (10–1000 μg/mL) also had the increment on colon tonus. On the other hand, ileum tension decreased in the presence of pharbitin. Conclusions The effects of resin glycoside of Pharbitidis Semen on colon tonus are different with those on ileum tonus isolated from mice. In the next step it is necessary to investigate details of its pharmacological mechanism.

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Section: Introductionmentioning

confidence: 99%