Morning granulocytopenia in two patients with connective-tissue disease treated with oral corticosteroids

Rigid Cooperation of Per1 and Per2 proteins

“…“Circadian” comes from the Latin circa (about) and dies (day). Many physiological functions have diurnal variation 1 2 3 that follows an approximately 24-h cycle and is regulated by an endogenous circadian clock 4 ; dysregulation of these functions leads to circadian disorders, including delirium 5 6 . The mechanism underlying the mammalian circadian clock is a transcriptional network that consists of a feedback loop of about 20 genes (clock genes) 7 8 .…”